检索结果-南通市图书馆

Global Stability in a Model for ctl response to HTLV-I Infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Quarterly Journal of Mathematics 2013年第4期28卷 618-624页

作者： SONG Qiang Department of Mathematics and Computer Science Xinyqng Vocational and Technical College Xinyang464000 China

In this paper, a mathematical model for HTLV-I infection of CD4＋ T cells that incorporates the CD8＋ cytotoxic T-cell（ctl） response is studied. We establish two threshold parameters Ro and R1, the basic reproduction numbers for viral persistence and for ctl response, respectively. We also show that the parameter R1 can be used to distinguish asymptomatic carriers from HAM/TSP patients and as an important control parameter for preventing the development of HAM/TSP.

关键词： ctl response HTLV-I infection global stability Lyapunov function

TLR9 agonist enhances radiofrequency ablation-induced ctl responses, leading to the potent inhibition of primary tumor growth and lung metastasis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第10期16卷 820-832页

作者： Aizhang Xu Lifeng Zhang Jingying Yuan Fatma Babikr Andrew Freywald Rajni Chibbar Michael Moser Wenjun Zhang Bing Zhang Zhaoying Fu Jim Xiang Cancer Research Saskatchewan Cancer AgencyUniversity of SaskatchewanSaskatoonSKCanada Department of Oncology University of SaskatchewanSaskatoonSKCanada Department of General Surgery The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Pathology University of SaskatchewanSaskatoonSKCanada Department of Surgery University of SaskatchewanSaskatoonSKCanada Department of Bioengineering University of SaskatchewanSaskatoonSKCanada Biomedical Science and Technology Research Center School of Mechatronic Engineering and AutomationShanghai UniversityShanghaiChina Department of Immunology College of MedicineYian-An UniversityYian-AnChina

Radiofrequency ablation(RFA)is the most common approach to thermal ablation for cancer ***,its efficacy is limited by incomplete ablation,and further optimization of RFA is ***,we demonstrate that incubation at 65°C triggers more EG7 tumor cell death by necrosis than treatment at 45°C,and the 65°C-treated cells are more effective at inducing antigen-specific CD8^(+)cytotoxic T lymphocyte(ctl)responses after injection in mice than the 45°C-treated *** cells(DCs)that phagocytose 65°C-treated EG7 cells become mature with upregulated MHCII and CD80 expression and are capable of efficiently inducing effector ctls in mouse tumor ***(65°C)therapy of EG7 tumors induces large areas of tumor necrosis and stimulates ctl *** leads to complete regression of small(~100 mm^(3))tumors but fails to suppress the growth of larger(~350 mm^(3))*** administration of the Toll-like receptor-9(TLR9)agonist unmethylated cytosine-phosphorothioate-guanine oligonucleotide(CpG)to DCs phagocytosing 65°C-treated EG7 cells enhances the expression of MHCII and CD40 on DCs as well as DC-induced stimulation of ctl ***,the intratumoral administration of CpG following RFA also increases the frequencies of tumor-associated immunogenic CD11b−CD11c^(+)CD103^(+)DC2 and CD11b+F4/80+MHCII+M1 macrophages and increases CD4^(+)and CD8^(+)T-cell tumor infiltration,leading to enhanced CD4^(+)T cell-dependent ctl responses and potent inhibition of primary RFA-treated or distant untreated tumor growth as well as tumor lung metastasis in mice bearing larger ***,our data indicate that CpG administration,which enhances RFA-induced ctl responses and ultimately potentiates the inhibition of primary tumor growth and lung metastasis,is a promising strategy for improving RFA treatment,which may assist in optimizing this important cancer therapy.

关键词： TLR9 agonist RFA ctl response antitumor immunity metastasis

Intercellular Trogocytosis Plays an Important Role in Modulation of Immune responses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2008年第4期5卷 261-269页

作者： Khawaja Ashfaque Ahmed Manjunatha Ankathatti Munegowda Jim Xiang Research Unit Saskatchewan Cancer AgencyDepartments of OncologyMicrobiology and ImmunologyCollege of MedicineUniversity of Saskatchewan20 Campus DriveSaskatoon Saskatchewan S7N 4H4Canada Research Unit Saskatchewan Cancer AgencyDepartments of OncologyMicrobiology and ImmunologyCollege of MedicineUniversity of Saskatchewan20 Campus Drive SaskatoonSaskatchewan S7N 4H4Canada

Intercellular communication is an important means of molecular information transfer through exchange of membrane proteins from cells to cells. Advent of the latest analytical and imaging tools has allowed us to enhance our understanding of the cellular communication through the intercellular exchange of intact membrane patches, also called trogocytosis, which is a ubiquitous phenomenon. Immune responses against pathogens or any foreign antigens require fine immune regulation, where cellular communications are mediated by either soluble or cell surface molecules. It has been demonstrated that the membrane molecule transfer between immune cells such as dendritic and T cells can be derived through internalization/recycling pathway, dissociation-associated pathway, uptake of exosomes and membrane nanotube formations. Recent evidence implicates the trogocytosis as an important mechanism of the immune system to modulate immune responses. Exchange of membrane molecules/ antigens between immune cells has been observed for a long time, but the mechanisms and functional consequences of these transfers remain unclear. In this review, we discuss the possible mechanisms of trogocytosis and its physiological relevance to immune system, with special reference to T cells and the stimulatory or suppressive immune responses derived from T cells with acquired dendritic cell membrane molecules. Cellular ＆ Molecular Immunology. 2008;5（4）：261-269.

关键词： cellular interaction membrane molecule transfer ctl response immune suppression

A novel delivery system of antigen induces strongly humoral immune and ctl responses

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel delivery system of antigen induces strongly humoral ...

Dynamics of an infection model with two delays

第十一届全国免疫学学术大会

作者： Yang Zishan Xu Miaomiao Wu Zhenzhou Zhao Liqing Hong Zhangyong Yin Zhinan College of Life Sciences Nankai University Biomedical Translational Research Institute Jinan University

Adjuvant priming immune response are required for vaccines against tumor or intracellular pathogen. β-glucan shell derived from yeast is an striking candidate adjuvant capable of triggering humoral immune and cellular immune. Herein,we encapsulated Ovalbumin inside the glucan particles(GP-OVA) using chitosan and glutaraldehyde by a similar waterin-oil micro-emulsion method. GP-OVA as like β-glucan can induce dendritic cells maturation, but also promoted the proliferation of OVA-specific CD8(OT1 cells) in vitro. Vaccination with GP-OVA enhanced the formation of germinal center, induced strong secretion of Th1-associated IgG2 a in addition to Th2-associated IgG1 compared with other groups. Moreover, ctl response induced by GP-OVA was determined by the IFN-γ production of CD8 cells. Finally, GP-OVA significantly delayed the onset of EG.7-OVA growth in the prophylatic and therapeutical tumor model. These results demonstrated that GP loading antigen system may be a promising platform for cancer immunotherapy.

关键词： Glucan particles Chitosan ctl response Adjuvant

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

International Journal of Biomathematics 2015年第5期8卷 295-315页

作者： Xinguo Sun Junjie Wei ＊Department of MathematicsHarbin Institute of Technology Harbin Heilongjiang 150001 P. R. China School of ScienceChina University of Petroleum (East China) Qingdao 266580 P. R. China

In this paper, a HTLV-I infection model with two delays is considered. It is found that the dynamics of this model are determined by two threshold parameters R0 and R1, basic reproduction numbers for viral infection and for ctl response, respectively. If R0 〈 1, the infection-free equilibrium P0 is globally asymptotically stable. If R1 〈 1 〈 R0, the asymptomatic-carrier equilibrium P1 is globally asymptotically stable. If R1 〉 1, there exists a unique HAM/TSP equilibrium P2. The stability of P2 is changed when the second delay T2 varies, that is there exist stability switches for P2.

关键词： HTLV-I infection ctl response delay Lyapunov functionals global stabi-lity Hopf bifurcation.

A fractlonal-order delay differential model for Ebola infection and CD8＋ T-cells response： Stability analysis and Hopf bifurcation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Biomathematics 2017年第8期10卷 103-124页

作者： V. Preethi Latha R. Rakkiyappan G. Velmurugan Department of Mathematics Bharathiar University Coimbatore 641 046 Tamil Nadu India Department of Mathematical Sciences College of Science UAE University AI-Ain 15551 UAE

In this paper, we study a fractional-order model with time-delay to describe the dynamics of Ebola virus infection with cytotoxic T-lymphocyte （ctl） response in vivo. The time- delay is introduced in the ctl response term to represent time required to stimulate the immune system. Based on fractional Laplace transform, some conditions on stability and Hopf bifurcation are derived for the model. The analysis shows that the fractional- order with time-delay can effectively enrich the dynamics and strengthen the stability condition of fractional-order infection model. Finally, the derived theoretical results are justified by some numerical simulations.

关键词： Ebola virus ctl response Hopf bifurcation stability time-delay.