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检索条件"主题词=CTCF"
76 条 记 录,以下是1-10 订阅
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Targeted core-shell nanoparticles for precise ctcf gene insert in treatment of metastatic breast cancer
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Bioactive Materials 2022年 第5期7卷 1-14页
作者: Jialun Duan Chunjie Bao Ying Xie Haitao Guo Yixuan Liu Jianwei Li Rui Liu Peishan Li Jing Bai Yan Yan Limin Mu Xueqi Li Guiling Wang Wanliang Lu State Key Laboratory of Natural and Biomimetic Drugs Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery SystemsAnd School of Pharmaceutical SciencesPeking UniversityBeijing100191China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing100875China
Clustered regularly interspaced short palindromic repeats(CRISPR)technology emerges a remarkable potential for cure of refractory cancer like metastatic breast cancer.However,how to efficiently deliver the CRISPR syst... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论
ctcf acetylation at lysine 20 is required for the early cardiac mesoderm differentiation of embryonic stem cells
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Cell Regeneration 2022年 第1期11卷 348-364页
作者: Shixin Gong Gongcheng Hu Rong Guo Jie Zhang Yiqi Yang Binrui Ji Gang Li Hongjie Yao Center for Health Research Joint School of Life SciencesCAS Key Laboratory of Regenerative BiologyGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhouChina Department of Life Sciences Changzhi UniversityChangzhiChina Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouChina Institute of Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Cancer Centre Faculty of Health SciencesMoE Frontier Science Centre for Precision OncologyUniversity of MacaoTaipaMacao SARChina
The CCCTC-binding factor(ctcf)protein and its modified forms regulate gene expression and genome organization.However,information on ctcf acetylation and its biological function is still lacking.Here,we show that ctcf... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论
DNA recognition patterns of the multi-zinc-finger protein ctcf: a mutagenesis study
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Acta Pharmaceutica Sinica B 2018年 第6期8卷 900-908页
作者: Jingjing Guo Ni Li Jiexiong Han Fei Pei Tianyu Wang Duo Lu Jiandong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicine Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College
CCCTC-binding factor(ctcf) is a zinc-finger protein, serving an important part in the genome architecture as well as some biochemical processes. Over 70,000 ctcf binding DNA sites have been detected genome-wide, and m... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
The DNA-binding factor ctcf critically controls gene expression in macrophages
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Cellular & Molecular Immunology 2014年 第1期11卷 58-70页
作者: Tatjana Nikolic Dowty Movita Margaretha EH Lambers Claudia Ribeiro de Almeida] Paula Biesta Kim Kreefft Marjolein JW de Bruijn Ingrid Bergen Niels Galjart Andre Boonstra Rudi Hendriks Department of Pulmonary Medicine Erasmus MC Rotterdam The Netherlands Department of Gastroenterology and Hepatology Erasmus MCRotterdam The Netherlands Department of Cell Biology and Genetics Erasmus MC Rotterdam The Netherlands Current address: Dr T Nikolic Department of Immunohematology and Blood Transfusion Leiden University Medical Center Leiden The Netherlands DrCR de Almeida Sir William Dunn School of Pathology University of Oxford Oxford UK. Both authors contributed equally
Macrophages play an important role in immunity and homeostasis. Upon pathogen recognition via specific receptors, they rapidly induce inflammatory responses. This process is tightly controlled at the transcriptional l... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论
Three-dimensional genome architectural CCCTC-binding factor makes choice in duplicated enhancers at Pcdhα locus
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Science China(Life Sciences) 2020年 第6期63卷 835-844页
作者: Yonghu Wu Zhilian Jia Xiao Ge Qiang Wu Center for Comparative Biomedicine MOE Key Lab of Systems BiomedicineState Key Lab of Oncogenes and Related GenesShanghai Cancer InstituteJoint International Research Laboratory of Metabolic&Developmental SciencesInstitute of Systems BiomedicineXin Hua HospitalShanghai Jiao Tong UniversityShanghai 200240China
During development, gene expression is spatiotemporally regulated by long-distance chromatin interactions between distal enhancers and target promoters. However, how specificity of the interactions between enhancers a... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Many facades of ctcf unified by its coding for three-dimensional genome architecture
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Journal of Genetics and Genomics 2020年 第8期47卷 407-424页
作者: Qiang Wu Peifeng Liu Leyang Wang MOE Key Lab of Systems Biomedicine State Key Laboratory of Oncogenes and Related GenesCenter for Comparative BiomedicineInstitute of Systems BiomedicineSchool of Life Sciences and BiotechnologyShanghai Jiao Tong University(SJTU)Shanghai200240China
CCCTC-binding factor(ctcf)is a multifunctional zinc finger protein that is conserved in metazoan species.ctcf is consistently found to play an important role in many diverse biological processes.ctcf/cohesin-mediated ... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
A Key to Genome Maze in 3D
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Genomics, Proteomics & Bioinformatics 2016年 第1期14卷 4-6页
作者: Zhihua Zhang CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences
How a genome with linear length over meters is compacted into the micrometer-sized nucleus of higher eukaryotic cells, and how this compaction affects and is affected by the genome functionalities have puzzled biologi... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Promote Connections of Young Computational Biologists in China
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Genomics, Proteomics & Bioinformatics 2013年 第4期11卷 253-256页
作者: Shihua Zhang Xiu-Jie Wang National Center for Mathematics and Interdisciplinary Sciences Academy of Mathematics and Systems ScienceChinese Academy of Sciences Center for Molecular Systems Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences
The first Youth Investigator Forum on Interdisciplinary Re- search of Mathematics, Computer Science and Biological Sci- ence (YMCB) took place on May 18-19, 2013 in Beijing, China. The conference was hosted by the N... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
MCF-7和HMEC细胞系特异的ctcf结合位点的预测
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内蒙古大学学报(自然科学版) 2022年 第2期53卷 158-165页
作者: 柴露 刘影 孙慧敏 刘俊杰 张利绒 内蒙古大学物理科学与技术学院 呼和浩特010021
转录因子可与特定的DNA序列结合调控基因的表达,研究发现转录因子ctcf的结合对乳腺癌等癌症的发生也有一定的影响。以乳腺癌细胞系(MCF-7)和乳腺正常细胞系(HMEC)为研究对象,分别构建癌细胞系特异的和正常细胞系特异的转录因子ctcf结合... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
ctcf介导aGVHD患者CD4+ T细胞中AhR低表达的机制研究
CTCF介导aGVHD患者CD4+ T细胞中AhR低表达的机制研究
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作者: 程婷婷 中南大学
学位级别:硕士
研究背景及目的:急性移植物抗宿主病(acute graft versus host disease,aGVHD)是异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,allo-HSCT)后,危及患者生命的严重并发症之一。越来越多的研究表明,Th17/Tre... 详细信息
来源: 同方学位论文库 同方学位论文库 评论