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G6PD Deficiency and COVID-19 in Burkina Faso: A Possible Link?

Journal of Biosciences and Medicines 2023年第1期11卷 57-69页

作者： Abdoul Karim Ouattara Lassina Traoré Tégwendé Rebeca Compaoré Théodora Mahoukèdè Zohoncon Jacques Simporé Université Norbert Zongo/Centre Universitaire de Manga Koudougou Burkina Faso Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE) UFR/SVT Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Département Biomédical et de Santé Publique Institut de Recherche en Sciences de la Santé (CNRST/IRSS) Ouagadougou Burkina Faso Faculté de Médecine Université Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso

Burkina Faso is a malaria-endemic country, with a high incidence of G6PD deficiency (G6PDd), which recorded its first case of COVID-19 in March 2020. G6PDd leads to a decrease in the efficiency of erythrocytes to combat oxidative stress, while SARS-CoV-2 infection induces massive production of Reactive Oxygen Species (ROS) in patients. In the present review, we discuss a possible link between G6PDd and SARS-CoV-2 infection. The mean prevalence of G6PDd in Burkina Faso is estimated at 16.6% among males and 6.5% among females. A total of 21,128 cases of COVID-19 have been recorded in Burkina Faso with 387 deaths reported (with a mortality rate of 1.15% among diagnosed cases) as of August 30, 2022. To our knowledge, no association study between G6PDd and SARS-CoV-2 infection has been conducted to date in Burkina Faso. However, several case reports around the world have described elevated risks of hemolysis and thrombosis, and other complications among G6PD-deficient patients infected with SARS-CoV-2. The use of Hydroxychloroquine (hcq) has also been deemed unsafe by some authors for the treatment of COVID-19 among patients with G6PDd. Although hcq has been shown to be well tolerated in COVID-19 patients in Burkina Faso, the drug could induce hemolytic crises in people with G6PD deficiency. G6PD is important in regulating ROS and maintaining erythrocyte homeostasis. In view of its high prevalence in Burkina Faso, determination of the G6PD status is required in COVID-19 patients for adequate management such as identifying a subset of COVID-19 patients for whom close monitoring and supportive care may be essential and to restrict treatment with hcq.

关键词： G6PD Deficiency COVID-19 cq/hcq Hemolysis Burkina Faso

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