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In silico evidence of Remdesivir action in blood coagulation cascade modulation in covid-19 treatment

World Journal of Biological Chemistry 2023年第4期14卷 72-83页

作者： Luis Gustavo Pagliarin Lucca Miketen de Oliveira Valentina Nunes Fontoura dos Anjos Cristiano de Bem Torquato de Souza Gabrielle Caroline Peiter Cinthia Façanha Wendel Anderson Dillmann Groto Fabrício Freire de Melo Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil Programa Multicêntrico de Pós-graduação em Bioquímica e Biologia Molecular-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Instituto Multidisciplinar em Saúde-Campus Anísio Teixeira Universidade Federal da BahiaVitória da Conquista 45.029-094BahiaBrazil

BACKGROUND Coronavirus disease 2019(covid-19)has demonstrated several clinical manifestations which include not only respiratory system issues but also liver,kidney,and other organ *** of these abnormalities is coagulopathies,including thrombosis and disseminated intravascular *** of this,the administration of low molecular weight heparin is required for patients that need to be *** addition,Remdesivir is an antiviral that was used against Middle East Acute Respiratory Syndrome,Ebola,Acute Respiratory Syndrome,and other diseases,showing satisfactory results on ***,there is evidence suggesting that this medication can provide a better prognosis for patients with *** To investigate in silico the interaction between Remdesivir and clotting factors,pursuing a possibility of using it as *** In this in silico study,the 3D structures of angiotensin-converting enzyme 2(ACE2),Factor I(fibrinogen),Factor II(prothrombin),Factor III(thromboplastin),Factor V(proaccelerin),Factor VII(proconvertin),Factor VIII(antihemophilic factor A),Factor IX(antihemophilic factor B),Factor X(Stuart-Prower factor),and Factor XI(precursor of thromboplastin(these structures are technically called receptors)were selected from the Protein Data *** structures of the antivirals Remdesivir and Osetalmivir(these structures are called ligands)were selected from the PubChem database,while the structure of Atazanavir was selected from the ZINC *** software AutoDock Tools(ADT)was used to prepare the receptors for molecular ***,peptides,water molecules,and other ones were removed from each ligand,and then,hydrogen atoms were added to the *** grid box was delimited and calculated using the same software ADT.A physiological environment with pH 7.4 is needed to make the ligands interact with the receptors,and still the software Marvin sketch®(ChemAxon®)was used to forecast the protonation *** perform m

关键词： Clotting factors Coagulating blood cascade covid-19 treatment Remdesivir SARS-CoV-2

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Gastrointestinal and hepatic side effects of potential treatment for covid-19 and vaccination in patients with chronic liver diseases

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World Journal of Hepatology 2021年第12期13卷 1850-1874页

作者： Man Fai Law Rita Ho Kimmy Wan Tung Law Carmen Ka Man Cheung Department of Medicine and Therapeutics Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Medicine North District HospitalHong KongChina West Island School Hong KongChina

The outbreak of coronavirus disease 2019(covid-19)is a global *** clinical trials have been performed to investigate potential treatments or vaccines for this disease to reduce the high morbidity and *** drugs of higher interest include umifenovir,bromhexine,remdesivir,lopinavir/ritonavir,steroid,tocilizumab,interferon alpha or beta,ribavirin,fivapiravir,nitazoxanide,ivermectin,molnupiravir,hydroxychloroquine/chloroquine alone or in combination with azithromycin,and ***(GI)symptoms and liver dysfunction are frequently seen in patients with covid-19,which can make it difficult to differentiate disease manifestations from treatment adverse *** symptoms of covid-19 include anorexia,dyspepsia,nausea,vomiting,diarrhea and abdominal *** injury can be a result of systemic inflammation or cytokine storm,or due to the adverse drug effects in patients who have been receiving different *** monitoring of liver function should be ***-19 vaccines have been rapidly developed with different technologies including mRNA,viral vectors,inactivated viruses,recombinant DNA,protein subunits and live attenuated *** with chronic liver disease or inflammatory bowel disease and liver transplant recipients are encouraged to receive vaccination as the benefits outweigh the *** against covid-19 is also recommended to family members and healthcare professionals caring for these patients to reduce exposure to the severe acute respiratory syndrome coronavirus 2 virus.

关键词： covid-19 treatment Gastrointestinal side effects Hepatic side effects covid-19 vaccine Chronic liver disease Liver transplantation

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Revisiting dexamethasone dosage in covid-19 management

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World Journal of Virology 2025年第1期14卷 124-126页

作者： Abhishet Varama Faculty of Medicine Chulalongkorn UniversityBangkok 10330Krung Thep Maha NakhonThailand

The ongoing coronavirus disease 2019(covid-19)pandemic has necessitated rapid advancements in therapeutic strategies,with dexamethasone emerging as a key treatment for severe *** editorial discusses the systematic review conducted by Sethi et al,published in the World Journal of *** review critically examines the efficacy and safety of varying dosages of dexamethasone in severe covid-19 patients,providing a comprehensive meta-analysis that underscores the current clinical recommendations favoring a low-dose *** these findings,the review highlights the potential benefits of tailored dosages for specific patient subgroups,suggesting a need for personalized treatment *** editorial expands on the implications of these findings,advocating for the integration of evolving clinical data into treatment protocols and calling for further research into patient-specific responses to *** emphasizes the importance of adaptability and precision in pandemic response,urging the medical community to consider both the robustness of existing evidence and the potential for innovative approaches to enhance patient outcomes in the face of global health challenges.

关键词： covid-19 treatment Dexamethasone dosage Personalized medicine Editorial Clinical adaptability

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Role of H2 receptor blocker famotidine over the clinical recovery of covid-19 patients: A randomized controlled trial

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World Journal of Clinical Cases 2022年第23期10卷 8170-8185页

作者： Abu Taiub Mohammed Mohiuddin Chowdhury Aktar Kamal Md Kafil Uddin Abbas Md Rezaul Karim Md Ahsan Ali Shubhashis Talukder H M Hamidullah Mehedi Hamid Hassan Abul Hossain Shahin Yarui Li Shuixiang He Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Ministry of Health and Family Welfare(OSDDGHS) Dhaka 1212Bangladesh Critical Care Unit M Abdur Rahim Medical College HospitalDinajpur 5200Bangladesh Critical Care Unit Cox's Bazar 250 Bed District Sadar HospitalCox's Bazar 4700Bangladesh Department of Neurology University Hospital LimerickLimerick V94 T9PXIreland Department of Histology Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Intensive Care Unit 250 Bed Chattogram General HospitalChittagong 4000Bangladesh Department of Medicine 250 Bed Chattogram General HospitalChittagong 4000Bangladesh Department of Emergency Chattogram Medical College HospitalChittagong 4000Bangladesh Department of Cardiology 250 Bed Chattogram General HospitalChittagong 4000Bangladesh

BACKGROUND Coronavirus disease 2019(covid-19)is a global pandemic putting the population at a high risk of infection-related health hazards,mortality and a potential failure of proper medical ***,it is necessary to evaluate the potential use of the existing drugs that could be used as options for the medical management of covid-19 *** To evaluate the role of the H_(2) receptor blocker“famotidine”in covid-19 *** This study was done on seriously ill covid-19 patients admitted to the intensive care unit(ICU)from different institutes in *** were divided into famotidine treatment group“A”(famotidine 40 mg to 60 mg oral formulation every 8 h with other treatment as given),and control group“B”(treatment as given).National early warning score(NEWS)-2,and sequential organ failure assessment day-1 score was calculated to evaluate the *** were evaluated by the time required for clinical improvement,characterized as duration required from enrollment to the achievement of NEWS-2 of≤2 maintained for 24 h;time to symptomatic recovery,defined as the duration in days(from randomization)required for the recovery of the covid-19 symptoms;mortality rate;duration of ICU and hospital stay;total period of hospitalization;the rate of supplementary oxygen requirement;the computed tomography(CT)chest recovery(%),the time required for the viral clearance and“NEWS-2”on *** A total of 208 patients were enrolled in this study with 104 patients in each *** famotidine treatment group had comparatively better recovery of 75%and a low mortality of 25%than the control with a recovery of 70%and a mortality of 30%.Duration of clinical improvement(group A 9.53 d,group B 14.21 d);hospitalization period among the recovered patients(group A 13.04 d,group B 16.31 d),pulmonary improvement in chest CT(group A 21.7%,group B 13.2%),and the time for viral clearance(group A 20.7 d,group B 23.8 d)were found to be statistically si

关键词： covid-19 SARS-CoV-2 Famotidine covid-19 acute respiratory distress syndrome covid-19 treatment Bangladesh

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World’s Fastest Supercomputer Picks covid-19 Drug

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Advances in Infectious Diseases 2020年第3期10卷 211-225页

作者： Zameer Shervani Intazam Khan Tasrina Khan Umair Yaqub Qazi Nanomaterials Production Division Food and Energy Security Research and Product Centre Sendai Japan Department of Neurology North Shore University Hospital Northwell Health Manhasset NY USA Department of Neurology and Neuroscience Weill Cornell Medical College New York NY USA Flushing Hospital Medical Center Flushing NY USA Biology Department University at Buffalo Buffalo USA Chemistry Department College of Science University of Hafar Al Batin Hafar Al Batin KSA

We have demonstrated the application of the world’s fastest supercomputer Fugaku located in Japan to select the covid-19 drugs and stopping the pandemic spread. Using computer simulation out of 2128 potential drug candidates, the world’s fastest supercomputer picked 30 most effective and potential drugs. Twelve of them are under clinical trials outside Japan;some are being tested in Japan. The computer reduced the computation time from one year to 10 days when compared to second superfast computer of the world. Fugaku supercomputer was employed to know the behavior of airborne aerosol covid-19 virus. 3Cs were suggested: avoid closed and crowded spaces and contacts to stop the pandemic spread. The progress in vaccine development and proper use and type of mask has also been described in this article. The article will benefit greatly to stop spreading and treating the pandemic covid-19.

关键词： covid-19 Drug World’s Fastest Supercomputer Fugaku Supercomputer covid-19 treatment covid-19 Prevention

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Immunological aspects of covid-19:What do we know?

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World Journal of Biological Chemistry 2020年第2期11卷 14-29页

作者： Tsvetelina Veselinova Velikova Stanislav Vasilev Kotsev Daniel Stefanov Georgiev Hristiana Momchilova Batselova Department of Clinical Immunology University Hospital LozenetzSofia 1407Bulgaria Department of Infectious Diseases Pazardzhik Multiprofile Hospital for Active TreatmentPazardzhik 4400Bulgaria Dental Faculty Medical University of PlovdivPlovdiv 4002Bulgaria Department of Epidemiology and Disaster Medicine Medical UniversityPlovdivUniversity Hospital“St George”Plovdiv 4002Bulgaria

The newly emerged coronavirus(severe acute respiratory syndrome coronavirus 2 SARS-CoV-2)and the disease that it causes coronavirus disease 2019(covid-19)have changed the world we ***,the origin and evolution of SARS-CoV-2 remain mostly *** virulence factors and immune mechanisms contribute to the deteriorating effects on the organism during SARS-CoV-2 *** humoral and cellular immune responses are involved in the pathophysiology of the disease,where the principal and effective immune response towards viral infection is the cell-mediated *** clinical picture of covid-19,which includes immune memory and reinfection,remains unclear and ***,many hopes are put in developing an effective vaccine against the virus,and different therapeutic options have been implemented to find effective,even though not specific,treatment to the *** can assume that the interaction between the SARS-CoV-2 virus and the individual's immune system determines the onset and development of the disease significantly.

关键词： SARS-CoV-2 covid-19 Immune memory Anti-SARS-CoV-2 antibodies covid-19 treatment Plasma therapy

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