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covid-19 infection and Homozygous SS Sickle Cell Disease in Children: About Two Cases in Ziguinchor/Senegal

Open Journal of Pediatrics 2020年第4期10卷 744-750页

作者： Lamine Thiam Noel Magloire Manga Chérif Mouhamadou Aidara Amadou Lamine Fall Ibrahima Diagne Ousmane Ndiaye Assane Seck University of Ziguinchor Ziguinchor Peace Hospital Ziguinchor Senegal Cheikh Anta Diop University in Dakar Albert Royer Children’s Hospital in Dakar Dakar Senegal Gaston Berger University of Saint Louis Saint Louis Regional Hospital Saint Louis Senegal

The World Health Organization declared that corona virus diseases-19 (covid-19) is a public health emergency. The covid-19 pandemic is more likely to cause disaster in developing area including West Africa due to limi... 详细信息

The World Health Organization declared that corona virus diseases-19 (COVID-19) is a public health emergency. The COVID-19 pandemic is more likely to cause disaster in developing area including West Africa due to limited medical resources. COVID-19 reportedly causes severer conditions in adults with advanced age and in patients with underlying comorbidities including sickle cell anemia. We recently experienced two pediatric patients with sickle cell disease (SS), who had COVID-19. We here highlight the difficulties of management and the severity of COVID-19 infection in children with homozygous sickle cell SS.

关键词： covid 19 infection Sickle Cell Disease Child

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Acute Pulmonary Embolism, Multiple Coronary Thrombosis, and Thrombi in the Left Ventricle and Ascending Aorta in a Patient with covid-19 infection

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Case Reports in Clinical Medicine 2021年第10期10卷 314-322页

作者： David Chipayo Gonzales Paloma Pérez Espejo Breda Hennessey Javier Fernández Portales Sebastián Romani Iván Núñ ez Gil Hospital Clínico San Carlos Madrid Spain Complejo Universitario de Cáceres Caceres Spain

Both arterial and venous thromboembolic events are common in patients hospitalized in intensive care units with severe covid-19. These patients often have laboratory findings consistent with a hypercoagulable state, suggesting widespread thrombosis and fibrinolysis, as well as elevated levels of D-dimer, von Willebrand factor (VWF), and factor VIII. There is increasing evidence that these thromboembolic events are associated with worse outcomes. We present the case of a 61-year-old man admitted for bilateral pneumonia due to covid-19 infection, who developed during his hospitalization;Bilateral pulmonary thromboembolism, an acute myocardial infarction due to multiple coronary thrombosis, an intracavitary thrombus and thrombus in the ascending aorta. The patient was treated with systemic fibrinolysis and full doses of anticoagulation for pulmonary embolism, an emergency primary percutaneous coronary intervention (PCI) was performed with the implant of a drug eluting stent (DES) in the left anterior descending artery (LAD). Triple therapy with aspirin, clopidogrel and heparin was maintained until discharge. After the patient discharge, aspirin was stopped and treatment with clopidogrel and dabigatran was maintained for three months. In a subsequent outpatient control, the thrombi of the left ventricle and the ascending aorta resolved.

关键词： covid 19 infection Pulmonary Embolism (PE) ST-Segment Elevation Myocardial Infarction (STEMI) Intracoronary Thrombosis Intra-Aortic Thrombus

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