检索结果-南通市图书馆

The HDAC3 enzymatic activity regulates skeletal muscle fuel metabolism

Journal of Molecular Cell Biology 2019年第2期11卷 133-143页

作者： Shiyan Song Yefei Wen Hui Tong Emanuele Loro Yingyun Gong Jidong Liu Sungguan Hong Lei Li Tejvir S.Khurana Maoping Chu Zheng Sun Children's Heart Center The Second Affiliated Hospital and Yuying Children's Hospital Institute of Cardiovascular Development and Translational MedicineWenzhou 325027 China Division of Endocrinology Diabetes and Metabolism Department of Medicine Baylor College of Medicine Houston TX 77030 USA Department of Physiology and Pennsylvania Muscle Institute Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Department of Chemistry Chung-Ang University Seoul Korea Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX 77030 USA

Histone deacetylase 3 (HDAC3) is a major HDAC, whose enzymatic activity is targeted by small molecule inhibitors for treating a variety of conditions. However, its enzymatic activity is largely dispensable for its function in embryonic development and hepatic lipid ***3 plays a pivotal role in regulating muscle fuel metabolism and contractile function. Here, we address whether these muscular functions of HDAC3 require its enzymatic activity. By mutating the NCoR/SMRT corepressors in a knock - in mouse model named NS-DADm, we ablated the enzymatic activity of HDAC3 without affecting its protein levels. Compared to the control mice, skeletal muscles from NS-DADm mice showed lower force generation, enhanced fatigue resistance, enhanced fatty acid oxidation, reduced glucose uptake during exercise, upregulated expression of metabolic genes involved in branchedchain amino acids catabolism, and reduced muscle mass during aging, without changes in the muscle fiber-type composition or mitochondrial protein content. These muscular phenotypes are similar to those observed in the HDAC3-depleted skeletal muscles, which demonstrates that, unlike that in the liver or embryonic development, the metabolic function of HDAC3 in skeletal muscles requires its enzymatic activity. These results suggest that drugs specifically targeting HDAC3 enzyme activity could be developed and tested to modulate muscle energy metabolism and exercise performance.

关键词： HDAC muscle metabolism nuclear receptor corepressor histone deacetylation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Androgen receptor functions in prostate cancer development and progression

引用

Asian Journal of Andrology 2014年第4期16卷 561-564页

作者： Steven P Balk Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA.

The androgen receptor （AR） is critical for the normal development ofprostate and for its differentiated functions. The consistent expression of AR in prostate cancer （PCa）, and its continued activity in PCa that relapse after androgen deprivation therapy （castration-resistant prostate cancer （CRPC））, indicate that at least a subset of these genes are also critical for PCa development and progression. This review addressed AR regulated genes that may be critical for PCa, and how AR may acquire new functions during PCa development and progression.

关键词： BETA-CATENIN NUCLEAR RECEPTOR TRANSCRIPTIONAL ACTIVITY PTEN LOSS corepressor SOX9 GENE INHIBITION CELLS PROLIFERATION

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chromatin remodeling regulated by steroid and nuclear receptors

引用

Cell Research 1997年第2期7卷 127-142页

作者： ALAN P WOLFFE(Laboratory of Molecular Embroyology Nat’l Institute ofChild Health and Human Development NIH Bldg, 18T,Rm. 106 Bethesda, MD 20892-5431 USA. e-mail:awlme @helix. nih.gov) Laboratory of Molecular Embroyology Nat'l Institute of Child Health and Human Development NIH USA

Coactivators and corepressors regulate transcriptionby controlling interactions between sequence-specific transcription factors, the basal transcriptional machinery andthe chromatin environment. This review consider the access of nuclear and steroid receptors to chromatin, theiruse of corepressors and coactivators to modify chromatinstructure and the implications for transcriptional *** assembly of specific nucleoprotein architectures andtargeted histone modification emerge as central controlling elements for gene expression.

关键词： Steroid receptor nuclear receptor coactitvator corepressor transcriptional activation nucleosome positioning histone modification transcriptional repression

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：