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Effects of therapeutic hypercapnia on inflammation and apoptosis after hepatic ischemia-reperfusion injury in rats

Chinese Medical Journal 2010年第16期123卷 2254-2258页

作者： LI Ai-min QUAN Yan GUO Yue-ping LI Wen-zhi CUI Xiao-guang Department of Anesthesiology second Affiliated Hospital Harbin Medical University Harbin Heilongjiang 150086 China

Background Therapeutic hypercapnia （TH） has been demonstrated to protect several organs ischemia-reperfusion *** study aimed to investigate the effects of therapeutic hypercapnia on hepatic ischemia-reperfusion injury （HIRI）.Methods Thirty adult male Wistar rats weighing （250 ± 20） g were randomized into 3 groups （n=10 in each）, group C （control group）, group A （hypercapnia group） and group B （co2 preconditioning group）.A segmental ischemia of the liver was induced by interrupting the blood vessels including the bile duct to the median and left lateral lobes for 60 minutes and all the animals were sacrificed after 240 minutes observation period of *** arterial pressure （MAP）and the blood gases were measured before ischemia （baseline） and at 30, 60, 120, 180 and 240 minutes after *** blood samples were obtained for determination of serum levels of TNF-α, IL-10, serum aspartate aminotransferase （AST） and alanine aminotransferase （ALT）.The histopathology of liver tissues was evaluated by light *** NF-κB expression and apoptotic hepatocytes were respectively determined by immunohistochemistry and TUNEL *** The serum levels of liver enzymes and TNF-α were significantly decreased while the IL-10 level was significantly increased in groups A and B than in group C （P 〈0.05）, and group B surpassed group A （P 〈0.05）.The histopathological scores, the NF-κB immunohistochemical score （IHS） and apoptotic index were significantly lower in groups A and B than in group C （P 〈0.05）, and the decrease in group B was more obvious than in group A （P〈0.05）.conclusion Therapeutic hypercapnia attenuates ischemia-reperfusion injury to the ***, the effects of co2preconditioning are outstandingly notable.

关键词： hypercapnia co2 preconditioning liver ischemia-reperfusion injury

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