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clif-SOFA and clif-c scores for the prognostication of acute-onchronic liver failure and acute decompensation of cirrhosis:A systematic review

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World Journal of Hepatology 2022年第12期14卷 2025-2043页

作者： Ebrahim Rashed Jonathan Soldera Acute Medicine University of South WalesCardiff CF371DLUnited Kingdom

BAcKGROUND Acute-on-chronic liver failure(AcLF)is a syndrome characterized by decompensation in individuals with chronic liver disease,generally secondary to one or more extra-hepatic organ failures,implying an elevated mortality *** decompensation(ad)is the term used for one or more significant consequences of liver disease in a short time and is the most common reason for hospital admission in cirrhotic *** European Association for the Study of Liver-chronic-Liver Failure(EASL-clif)Group modified the intensive care Sequential Organ Failure Assessment score into clif-SOFA,which detects the presence of AcLF in patients with or without ad,classifying it into three *** To investigate the role of the EASL-clif definition for AcLF and the ability of clif-SOFA,clif-c AcLF,and clif-c ad scores for prognosticating AcLF or *** This study is a literature review using a standardized search method,conducted using the steps following the guidelines for reporting systematic reviews set out by the PRISMA *** specific keywords,relevant articles were found by searching PubMed,ScienceDirect,and BioMed *** databases were searched using the search terms by one reviewer,and a list of potentially eligible studies was generated based on the titles and abstracts *** data were then extracted and assessed on the basis of the Reference citation Analysis(https://***/).RESULTS Most of the included studies used the EASL-clif definition for AcLF to identify cirrhotic patients with a significant risk of short-term *** primary outcome in all reviewed studies was *** of the study findings were based on an area under the receiver operating characteristic curve(AUROc)analysis,which revealed that clifSOFA,clif-c AcLF,and clif-c ad scores were preferable to other models predicting 28-d *** AUROc scores were higher and able to predict all-cause mortality at 90,180,and 365 d.A total

关键词： End-stage liver disease Acute-on-chronic liver failure clif-SOFA clif-c AcLF clif-c ad

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