检索结果-南通市图书馆

Non-viral vector mediated ckb11 with folic acid modification regulates macrophage polarization and DC maturation to elicit immune response against cancer

引用

Bioactive Materials 2021年第11期6卷 3678-3691页

作者： Wen Nie Ting Yu Xiaoxiao Liu Bilan Wang Tingting Li Yin Wu Xikun Zhou Lu Ma Yunfeng Lin Zhiyong Qian Xiang Gao Department of Neurosurgery1nd Institute of Neurosurgery State Key Laboratory of Biotherapy1nd Cancer CenterWest China HospitalWest China Medical SchoolSichuan University1nd Collaborative Innovation Center for BiotherapyChengdu610041PR China Department of Medical Oncology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310003China Department of Pathology1nd Laboratory of Pathology State Key Laboratory of BiotherapyWest China HospitalWest China School of MedicineSichuan UniversityChina Department of Radiation Oncology Cancer CenterAffiliated Hospital of Xuzhou Medical UniversityJiangsu Center for the Collaboration1nd Innovation of Cancer BiotherapyCancer InstituteXuzhou Medical UniversityXuzhou221000China Department of Pharmacy West China Second University Hospital of Sichuan UniversityChengdu610041China State Key Laboratory of Oral Diseases National Clinical Research Centre for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China College of Biomedical Engineering Sichuan UniversityChengdu610041China

The immunosuppressive tumor microenvironment(TME)of cancer strongly hinders the anti-tumor immune responses,thereby resulting in disappointing responses to *** and promotive traits of chemokines exerted on leukocytes have garnered interest in improving the efficiency of immunotherapy by increasing the infiltration of immune cells in the *** this study,a folic acid(FA)-modified gene delivery system based on the self-assembly of DOTAP,MPEG-PCL-MPEG,and FA-PEG-PCL-PEG-FA,namely F-PPPD,was developed to deliver plasmids encoding the immunostimulating chemokine *** delivery of plasmid ckb11(pckb11)by F-PPPD nanoparticles resulted in the high secretion of ckb11 from tumor cells,which successfully activated T cells,suppressed the M2 polarization of macrophages,promoted the maturation of dendritic cells(DCs),facilitated the infiltration of natural killer(NK)cells and inhibited the infiltration of immunosuppressive cells in tumor *** of F-PPPD/pckb11 also significantly suppressed the cancer *** study demonstrated a nanotechnology-enabled delivery of pckb11,that remodeled the immunosuppressive TME,for cancer treatment.

关键词： Cancer Immunogene therapy ckb11 Nanocomposites Macrophages polarization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：