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世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 40-41页

作者： Eerola J. Tienari P.J. Kaakkola S. 邓剑平 Dr.Department of Neurology HUCH PO Box 340 FIN-00029 HUS Helsinki Finland

Objective: To assess the accuracy and clinical usefulness of [ 123I]β-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane)-SPECT in the differential diagnosis of Parkinson’s disease. Subjects: 185 consecutive patients with symptoms of movement disorder were studied. The diagnoses were Parkinson’s disease (92), essential tremor (16), vascular parkinsonism (15), various Parkinson plus syndromes (P+) (12), dementia with Lewy bodies (DLB) (5), dystonia (5), drug induced movement disorder (12), and other diagnoses (8). A reference group (psychogenic parkinsonism) comprised 20 subjects with complaints suggesting extrapyramidal disease but with no unequivocal signs on clinical examination and no abnormalities on brain imaging. Results: β-CIT uptake was significantly lower in the whole striatum as well as separately in the putamen and in the caudate nucleus in Parkinson’s disease than in the reference group or in drug induced movement disorder, essential tremor, or dystonia. The uptake of β-CIT in the vascular parkinsonism group was heterogeneous and mean β-CIT uptake fell between the reference group and the Parkinson’s disease group. In the P+and DLB groups the striatal uptake ratios overlapped those of the Parkinson’s disease group. Conclusions: [123I]β-CIT SPECT may not be as useful a tool in the clinical differential diagnosis of Parkinson’s disease as was previously believed, but it was 100%sensitive and specific for the diagnosis in younger patients (age 55 years)-specificity was substantially lower (68.5%). This differential specificity reflected the different distribution of differential diagnostic disorders (P+, DLB, vascular parkinsonism) in the older and younger age groups.

关键词：临床实践 citspect 特发性震颤肌张力障碍帕金森综合征锥体外系疾病纹状体鉴别诊断运动障碍壳核

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采用[^(123)I]β-citspect检测帕金森病患者的神经变性与睡眠微观结构

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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 27-28页

作者： Happe S. Anderer P. PirkerW. 李锐 Dept. of Clinical Neurophysiology University of Gttingen Robert- Koch- Str. 40 37099 Gttingen Germany Dr.

Objectives Along with spindles, K- complexes are well known hallmarks of stage 2 (S2) sleep. However, little is known about their quantity in S2 sleep of patients with Parkinson’ s disease (PD). Setting Sleep laboratory, Department of Neurology, University of Vienna, Austria. Patients and methods Whole- night polysomnography (PSG) was performed in twelve treated PD patients and ten healthy controls without history of sleep complaints. The quantity of spontaneous K- complexes, K- alpha- complexes, and sleep spindles in one hour S2 sleep, distributed in four epochs of 15 minutes all through the night, were visually selected and analysed. The quantity and the temporal course of these phasic events were compared with the quantity in age- matched healthy controls. Nine of the twelve PD patients underwent [123I]β - CIT SPECT for calculating dopamine transporter binding in the striatum and serotonin transporter density in the thalamus- hypothalamus region. Results There was no difference between the quantity of K- complexes, K- alpha- complexes, and sleep spindles in PD patients and in the healthy control group. K- complexes but not sleep spindles decreased over the night in both groups. The number of sleep spindles did not correlate with the dopamine transporter binding in the striatum or the serotonin binding in the thalamic/hypothalamic region. Conclusion K- complexes and sleep spindles are not reduced and do not seem to be related to the degree of dopaminergic degeneration in treated PD patients.

关键词：帕金森病神经变性 citspect 睡眠纺锤波复合波纹状体微观结构多巴转运体睡眠研究

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