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Journal of Integrative Nursing 2024年第1期6卷 3-14页

作者： Yuyin CHEN Yuhua QIU Kaimin ZHOU Ruyi TAN Wanlin PENG Xiuhong LONG Meijiang CHEN School of Nursing Guangxi University of Chinese MedicineNanningChina Department of Respiratory disease Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanningChina Department of Nursing Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanningChina

Objective:Previous research has demonstrated that pulmonary Daoyin could be an efficacious way to ameliorate the physical and psychological state of sufferers with chronic obstructive pulmonary disease(COPD)and bolster the quality of ***,the results are not ***,the objective of this research is to assess the impacts of pulmonary Daoyin in individuals with ***:Relevant articles were searched in Web of Science,Cochrane Library,PubMed,EMBASE,SinoMed,CNKI,Wanfang,and VIP from database inception to January ***:There were a total of 15 randomized controlled trials(RCTs)included in this meta-analysis involving 1732 patients,of which 864 participated in the intervention group and 868 in the control *** comparing with the control group,the COPD patients practicing pulmonary Daoyin demonstrated a significant improvement in 6 min walking distance(mean difference[MD]=24.53,95%confidence interval[CI][18.55,30.52],Ppulmonary Daoyin on exercise ability,breathlessness,and pulmonary function in COPD *** rigorous RCTs with larger samples and longer-term interventions will be required moving forward.

关键词： chronic obstructive pulmonary disease exercise capacity meta-analysis pulmonary Daoyin pulmonary function rehabilitation

Clinical Research Progress of Peripheral Blood Eosinophils in chronic obstructive pulmonary disease

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Journal of Clinical and Nursing Research 2024年第6期8卷 189-194页

作者： Chunxi Li Fuyang Sixth People's Hospital Fuyang 236300Anhui ProvinceChina

chronic obstructive pulmonary disease(COPD)accounts for one of the major health and economic burdens *** a heterogeneous disease,the underlying inflammatory pattern of COPD differs from the previously thought neutrophil-dominated inflammation,with eosinophilic inflammation occupying approximately one third of stable *** the eosinophil(EOS)threshold associated with clinical relevance in patients with COPD is currently debated,eosinophil count can be used as a biomarker to guide treatment and to assess the risk of acute exacerbations of COPD,the efficacy of inhaled corticosteroids,and clinical *** purpose of this review is to describe the biological characteristics of eosinophils and the related research progress as clinical biomarkers.

关键词： chronic obstructive pulmonary disease Eosinophils Biomarkers

Analysis of the Effect of Respiratory Rehabilitation Nursing on the Quality of Life of Patients with chronic obstructive pulmonary disease

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Journal of Clinical and Nursing Research 2024年第5期8卷 342-347页

作者： Meini Li Hechi Third People’s Hospital Hechi 547000Guangxi ProvinceChina

Objective:To understand the impact of respiratory rehabilitation nursing on the quality of life of patients with chronic obstructive pulmonary disease(COPD),and to provide a theoretical basis for better clinical implementation of this nursing ***:68 COPD patients admitted from September 2022 to July 2023 were selected to determine the type of COPD(mild,moderate,severe)based on clinical manifestations and laboratory test results,and were divided into a study group(42 cases)and a control group(26 cases),with the control group adopting the conventional treatment plan,and the patients in the study group receiving individualized respiratory rehabilitation nursing *** patients’respiratory function and quality of life after treatment are ***:The total score of the study group(65.71±12.02)was significantly higher than that of the control group(52.73±11.54),and the difference was statistically significant(Ppulmonary function,the results of pulmonary function tests of the two groups of patients were in the normal range after treatment,and the study group was slightly better than that of the control group,and the difference was statistically significant(P<0.05);the score of the study group in terms of exercise endurance was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Respiratory rehabilitation nursing can effectively improve the quality of life of COPD patients,and is worthy of popularization and application.

关键词： Respiratory rehabilitation nursing chronic obstructive pulmonary disease Quality of life

Comparative Analysis of Budesonide Treatments on Blood Gas and Inflammation in chronic obstructive pulmonary disease Remission

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Journal of Clinical and Nursing Research 2024年第5期8卷 206-211页

作者： Wei Liu Department of Family Medicine Zhongshan HospitalDalian UniversityDalian 116001LiaoningChina

Objective:To investigate the effects of budesonide on blood gas and inflammation indexes in patients with chronic obstructive pulmonary disease(COPD)during ***:Fifty-one patients with COPD in remission,admitted to Zhongshan Hospital of Dalian University from July 2021 to December 2022,were selected and divided into two groups based on a randomized numerical table *** control group(25 cases)received budesonide formoterol treatment,while the observation group(26 cases)received budesonide geforce *** indexes,including clinical efficacy,blood gas indexes,inflammation indexes,***’s Respiratory Questionnaire(SGRQ)scores,chronic obstructive pulmonary disease Assessment Test(CAT)scores,and 6-minute Walking Distance Test(6MWD)results,were compared between the two ***:After 21 days of treatment,the total clinical effectiveness rate of the observation group was higher than that of the control group,with a statistically significant difference(P<0.05).Post-treatment,the PaO2 level and pH value in both groups were higher,and the PaCO_(2) level was lower compared to pre-treatment *** observation group showed better improvements in these indicators than the control group,with statistically significant differences(P<0.05).SGRQ and CAT scores for both groups were lower post-treatment,with the observation group scoring lower than the control ***,the 6MWD results were farther for both groups post-treatment,with the observation group achieving greater distances than the control group,with statistically significant differences(P<0.05).Conclusion:Budesonide can effectively improve blood gas indexes in patients with COPD in remission,alleviate related clinical symptoms,reduce inflammatory responses,and promote patient *** treatment efficacy is significant.

关键词： chronic obstructive pulmonary disease Recovery Budesonide Blood gas indices

Study on the impact of comprehensive geriatric assessment on anxiety and depression in chronic obstructive pulmonary disease patients

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World Journal of Clinical Cases 2024年第20期12卷 4057-4064页

作者： Xian-Rong Shi Wen-Li Wu Chun-Yan Li Jiao Ao Hai-Xia Xiong Jing Guo Yan Fang Department of Nursing The First People’s Hospital of Jiangxia DistrictWuhan 430000Hubei ProvinceChina Respiratory and Critical Care Medicine The First People’s Hospital of Jiangxia DistrictWuhan 430000Hubei ProvinceChina Department of Intensive Care Medicine The First People’s Hospital of Jiangxia DistrictWuhan 430000Hubei ProvinceChina

BACKGROUND Psychological factors such as anxiety and depression will not only aggravate the symptoms of chronic obstructive pulmonary disease(COPD)patients and reduce the quality of life of patients,but also affect the treatment effect and long-term ***,it is of great significance to explore the clinical application of senile comprehensive assessment in the treatment of COPD and its influence on psychological factors such as anxiety and *** To explore the clinical application of comprehensive geriatric assessment in COPD care and its impact on anxiety and depression in elderly *** In this retrospective study,60 patients with COPD who were hospitalized in our hospital from 2019 to 2020 were randomly divided into two groups with 30 patients in each *** control group was given routine nursing,and the observation group was given comprehensive *** symptoms,quality of life[COPD assessment test(CAT)score],anxiety and depression Hamilton Anxiety Rating Scale(HAMA)and Hamilton Depression Rating Scale(HAMD)were compared between the two *** CAT scores in the observation group decreased from an average of 24.5 points at admission to an average of 18.3 points at discharge,and in the control group from an average of 24.7 points at admission to an average of 18.3 points at *** average score was 22.1(P<0.05).In the observation group,HAMA scores decreased from 14.2 points at admission to 8.6 points at discharge,and HAMD scores decreased from 13.8 points at admission to 7.4 points at *** mean HAMD scores in the control group decreased from an average of 14.5 at admission to an average of 12.3 at discharge,and from an average of 14.1 at admission to an average of 11.8 at *** The application of comprehensive geriatric assessment in COPD care has a significant effect on improving patients'clinical symptoms and quality of life,and can effectively reduce patients'anxiety and depres

关键词： chronic obstructive pulmonary disease Comprehensive geriatric assessment Anxiety Depression Retrospective study Hamilton Anxiety Rating Scale

Anti-inflammatory effects of Tao Hong Si Wu Tang in mice with lung cancer and chronic obstructive pulmonary disease

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World Journal of Clinical Oncology 2024年第9期15卷 1198-1206页

作者： Guo-Li Wang Yan-Ling Xu Ke-Ming Zhao Ai-Feng Sui Li-Na Wang Hu Deng Ge Wang First Department of Respiratory and Critical Care Medicine/pulmonary disease The First Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina Second Department of Respiratory and Critical Care Medicine/pulmonary disease The First Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina Department of Spleen and Stomach Oncology The Fourth Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110101Liaoning ProvinceChina

BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of ***-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with *** studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy *** To observe the effects of THSW on COPD and LC in *** A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell *** The blank control group exhibited a clear alveolar *** model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating *** changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control *** serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlev

关键词： Tao Hong Si Wu Tang Anti-inflammatory chronic obstructive pulmonary disease Lung cancer Traditional Chinese medicine

Clinical Study on Respiratory Medicine Treatment of chronic obstructive pulmonary disease Combined with Respiratory Failure

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Journal of Clinical and Nursing Research 2024年第5期8卷 293-298页

作者： Jianhua Yu Sanshandao Street Community Health Service Center Laizhou CityYantai 261418Shandong ProvinceChina

Objective:To explore the respiratory medicine treatment methods for treating chronic obstructive pulmonary disease(COPD)combined with respiratory ***:70 cases of COPD patients with combined respiratory failure admitted to our hospital from January 2021 to January 2023 were selected as the study subjects,and randomly divided into the control group and the experimental group,each with 35 *** control group received only conventional treatment,and the experimental group received non-invasive positive pressure ventilation,and the treatment effects and changes in the levels of IL-18,hs-CRP,and CES2 inflammatory factors were observed and evaluated in the two ***:There was no significant difference between the general data of the two groups(P>0.05);after treatment,the total effective rate of clinical efficacy of the observation group(91.43%)was significantly higher than that of the control group(71.43%),and the difference showed a significant correlation(Pchronic obstructive pulmonary disease accompanied by respiratory failure,showing a good clinical application prospect.

关键词： chronic obstructive pulmonary disease Respiratory failure Non-invasive positive pressure ventilation Therapeutic effect Inflammatory factor

Clinical Efficacy and Safety Analysis of Tigecycline in the Treatment of Acute Exacerbation of chronic obstructive pulmonary disease Combined with Multidrug-Resistant Acinetobacter baumannii Infection

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Journal of Clinical and Nursing Research 2024年第5期8卷 194-199页

作者： Hongbing Wang Nantong RICH Hospital Nantong 226000Jiangsu ProvinceChina

Objective:To study the clinical efficacy and safety of tigecycline in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD)combined with multidrug-resistant Acinetobacter baumannii ***:113 patients with acute exacerbation of COPD combined with multidrug-resistant Acinetobacter baumannii infection were recruited between January 2021 and January 2023,and given tigecycline *** total effective rate,lung function indexes,related biochemical index levels,and the incidence rate of adverse reactions were observed after the ***:After the treatment,100 patients were cured,1 case with apparent effect,2 cases were effective,10 cases were ineffective,and the total effective rate was 91.15%.The post-treatment CRP(21.22±3.35 mg/L),PCT(3.18±1.11 ng/L),CRE(76.36±9.24μmol/L),and ALT(37.76±6.99 U/L)were significantly improved as compared to the pre-treatment(P<0.05).After treatment,10 cases of vomiting(8.85%),13 cases of nausea(11.50%),4 cases of diarrhea(3.53%),1 case of abdominal pain(0.88%),and 2 cases of allergy(1.77%)were observed in 113 ***:Tigecycline therapy for patients with acute exacerbation of COPD combined with multidrug-resistant Acinetobacter baumannii infection not only has significant therapeutic efficacy but also has a high degree of safety.

关键词： Tigecycline chronic obstructive pulmonary disease Acute exacerbation Multidrug-resistant Acinetobacter baumannii infection

The Effect of O2O Education Combined with Peer Education Management Model in Patients with chronic obstructive pulmonary disease

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Journal of Contemporary Educational Research 2024年第4期8卷 92-100页

作者： Xiangli Zhang Qian Zhang Junying Nie Ting Li Shaanxi Provincial People’s Hospital Xi’an 710068Shaanxi ProvinceChina

Objective:To explore the effect of online-to-offline(O2O)education combined with the peer education management model in patients with chronic obstructive pulmonary disease(COPD).Methods:Using convenience sampling,72 patients with COPD who were hospitalized in the respiratory medicine department of a tertiary-level hospital from March to December 2021 were selected as study *** grouping was carried out using the random number table method,the control group was given routine COPD health education in the department,and the intervention group applied O2O trinity health management combined with peer education on the basis of routine *** 6 months of follow-up after discharge,the two groups were observed and compared for changes in pulmonary function,depression status,self-care ability,and quality of ***:At 3 and 6 months after the intervention,the lung function indexes and depression status of the two groups of patients improved significantly,and the improvement effect was more significant in the intervention group(P<0.05);after the intervention,the self-care ability scores of the patients in the intervention group were significantly higher than those of the control group(P<0.05);the quality-of-life scores of the two groups of patients decreased at 3 months after discharge,in which the quality-of-life scores in the intervention group was significantly lower than that of the control group(P<0.05).Conclusion:O2O education combined with the peer education management model can effectively improve the lung function of patients with COPD,depression,self-care ability,and quality of life.

关键词： Online-to-offline education chronic obstructive pulmonary disease Self-care ability Quality of life

Effects of acetylcysteine on micro-inflammation and pulmonary ventilation in chronic obstructive pulmonary disease exacerbation

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World Journal of Clinical Cases 2024年第18期12卷 3482-3490页

作者： Li-Yuan Huang Bin Huang Zheng Lv Xiao-Dan Lu Department of Integration of Traditional Chinese and Western Medicine School of Clinical MedicineChangchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Department of Infectious diseases Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Zoology School of Life SciencesChangchun Normal UniversityChangchun 130032Jilin ProvinceChina Precision Medical Center Jilin Province General HospitalChangchun 130021Jilin ProvinceChina

BACKGROUND Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)is a serious complication of chronic obstructive pulmonary disease,often characterized by increased morbidity and *** traditional Chinese medicine,AECOPD is linked to phlegm-heat and blood-stasis,presenting symptoms like thick sputum,fever,and chest *** has been shown that acetylcysteine inhalation in conjunction with conventional therapy significantly reduced inflammatory markers and improved lung function parameters in patients with AECOPD,suggesting that acetylcysteine may be an important adjunctive therapy for patients with phlegm-heat-blood stasis type *** To investigate the effect of acetylcysteine on microinflammation and lung ventilation in patients with phlegm-heat and blood-stasis-type *** One hundred patients with phlegm-heat and blood-stasis-type AECOPD were randomly assigned to two *** treatment group received acetylcysteine inhalation(10%solution,5 mL,twice daily)along with conventional therapy,whereas the control group received only conventional *** treatment duration was 14 *** markers(C-reactive protein,interleukin-6,and tumor necrosis factor-alpha)in the serum and sputum as well as lung function parameters(forced expiratory volume in one second,forced vital capacity,and peak expiratory flow)were assessed pre-and *** inhalation led to significant reductions in inflammatory markers and improvements in lung function parameters compared to those in the control group(P<0.05).This suggests that acetylcysteine could serve as an effective adjunct therapy for patients with phlegm-heat and blood-stasis-type *** Acetylcysteine inhalation significantly reduced inflammatory markers in the serum and sputum and improved lung ventilation function parameters in patients with phlegm-heat and blood-stasis type AECOPD compared with the control *** differences were statistically significant(P

关键词： Acute exacerbation chronic obstructive pulmonary disease Traditional Chinese medicine Acetylcysteine Phlegm-heat and blood-stasis Lung ventilation function