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Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study

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Frontiers of Medicine 2020年第6期14卷 752-759页

作者： Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong Wuhan No.1 Hospital(Wuhan Integrated TCM&Western Medicine Hospital) Wuhan 430022China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China GCP ClinPlus Co. Ltd.Beijing 100160China Beijing University of Chinese Medicine Beijing 100029China Hubei University of Traditional Chinese Medicine Wuhan 430060China

This study aimed to evaluate the efficacy of Chinese herbal medicine(chm)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(chm users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 chm users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 chm users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of chm users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;Pchm may reduce the mortality of patients with severe/critical COVID-19.

关键词： COVID-19 chm mortality a retrospective cohort study

Clinical outcomes of influenza-like illness treated with Chinese herb- al medicine： an observational study

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Journal of Traditional Chinese Medicine 2018年第1期38卷 107-116页

作者： Li Xiaoyan Cecilia Stalsby Lundborg Ding Banghan Chen Bojun Zhou Hong Li Jiqiang Ou Aihua OuyangWenwei Wen Zehuai Lu Chuanjian Gaetano Marrone Key Unit of Methodology in Clinical Research Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510120 China Department of Public Health Sciences Karolinska Institutet Stockholm 17177 Sweden Department of Emergency Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510120 China National Center for Design Measurement and Evaluation in Clinical Research Guangzhou University of Chinese Medicine Guangzhou 510405 China medical Department Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510120 China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou 510120 China

OBJECTIVE: To present and analyze treatmentsand clinical outcomes of Chinese patients with influenza-like illness.METHODS: We conducted a multi-site observational study from December 2009 to April 2010. Patients with influenza-like illness from 45 hospitals were enrolled. Patients received Chinese herbal medicine(chm), conventional treatments, or chm plus conventional treatments(combination treatment) according to the guidelines for influenza A/H1 N1 2009 in China. The primary outcomes were the time to alleviation of symptoms and the incidence of complications. The secondary outcomes were the time until becoming afebrile, incidence of severe illness, testing negative on an influenza A viral test, and total medical fees.RESULTS: In total, 5967 patients were enrolled. The percentages of patients prescribed chm alone, conventional treatment, and combination treatment were 27.8%, 5.1%, and 67.7%, respectively. There were no significant differences in the time to alleviation of symptoms, incidence of complications,time to becoming afebrile, or rate of severe illness among the chm, conventional, and combination treatment groups. The rates of testing negative on the influenza virus A rapid test and H1 N1 virus test were 90.3% and 76.3%, respectively. However,significant differences were found in the total medical fees among the three groups: chm treatments were more economical than the other two treatments.CONCLUSION: The efficacy of chm for influenza-like illness was not different from that of conventional treatments, but it was more economical.

关键词：流行性感冒病毒临床 al 联合治疗植物汉语 chm 并发症

Object-based forest gaps classification using airborne LiDAR data

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Journal of Forestry Research 2019年第2期30卷 617-627页

作者： Xuegang Mao Jiyu Hou School of Forestry Northeast Forestry University School of Geographic and Oceanographic Sciences Nanjing University

Object-based classification differentiates forest gaps from canopies at large regional scale by using remote sensing data. To study the segmentation and classification processes of object-based forest gaps classification at a regional scale, we sampled a natural secondary forest in northeast China at Maoershan Experimental Forest Farm.Airborne light detection and ranging(LiDAR; 3.7 points/m2) data were collected as the original data source and the canopy height model(chm) and topographic dataset were extracted from the LiDAR data. The accuracy of objectbased forest gaps classification depends on previous segmentation. Thus our first step was to define 10 different scale parameters in chm image segmentation. After image segmentation, the machine learning classification method was used to classify three kinds of object classes, namely,forest gaps, tree canopies, and others. The common support vector machine(SVM) classifier with the radial basis function kernel(RBF) was first adopted to test the effect of classification features(vegetation height features and some typical topographic features) on forest gap classification.Then the different classifiers(KNN, Bayes, decision tree,and SVM with linear kernel) were further adopted to compare the effect of classifiers on machine learning forest gaps classification. Segmentation accuracy and classification accuracy were evaluated by using Mo¨ller's method and confusion metrics, respectively. The scale parameter had a significant effect on object-based forest gap segmentation and classification. Classification accuracies at different scales revealed that there were two optimal scales(10 and 20) that provided similar accuracy, with the scale of 10 yielding slightly greater accuracy than 20. The accuracy of the classification by using combination of height features and SVM classifier with linear kernel was91% at the optimal scale parameter of 10, and it was highest comparing with other classification classifiers, such as SVM RBF(90%), Decision Tree(90%), Bayes(90%),or KNN(87%

关键词： Forest gap Scale segmentation Classification feature LiDAR chm Object based Machine learning

基于增强Frost局部滤波及单木距离图标记重构的chm树冠分割

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南京林业大学学报(自然科学版) 2023年

作者：张华聪谭新建喻龙华厉月桥陈永富刘仁张怀清中国林业科学研究院资源信息研究所中国林业科学研究院亚热带林业实验中心国家林业和草原局林业遥感与信息技术重点实验室

[目的] 利用增强Frost局部滤波和单木距离图重构标记技术对冠层高度模型(chm)进行分割，以提高无人机激光雷达在单木树冠分割的精度和效率。[方法]选取江西分宜山下实验林场阔叶混交林、针叶混交林和针阔混交林3个不同类型的林分为研究... 详细信息

[目的] 利用增强Frost局部滤波和单木距离图重构标记技术对冠层高度模型(chm)进行分割，以提高无人机激光雷达在单木树冠分割的精度和效率。[方法]选取江西分宜山下实验林场阔叶混交林、针叶混交林和针阔混交林3个不同类型的林分为研究对象，以无人机激光雷达数据为数据源，构建chm。针对高分辨率chm树冠区域孔隙较多的问题，利用增强Frost局部滤波处理优化chm，优化结果与不同滤波方法进行了比较分析。然后应用距离图重构标记分割技术对增强Frost局部滤波优化后的0.2、0.5、1.0及1.5 m分辨率的chm进行分割与分析，最后确定最佳分辨率的chm，并其将分割结果与同等分辨率下分水岭算法以及点云分割均值偏移算法结果进行比较。[结果]采用增强Frost局部滤波处理的chm优化效果显著，在有效抑制树冠噪音的同时，也能较好地保留图像细节信息。0.2m分辨率的chm分割效果最佳。距离图标记重构分割方法分割针叶混交林、针阔混交林、阔叶混交林3种不同林分类型的分割精度(OA)分别为0.96、0.84、0.75；根据树冠分割结果计算单木冠幅，冠幅估测R2分别为0.83、0.82、0.71。[结论]基于增强Frost局部滤波及距离图重构标记技术可实现对激光点云chm的单木分割和树冠估算，能够满足森林调查和监测的基本需求。

关键词：无人机激光点云 chm 增强Frost滤波距离图重构标记树冠分割

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基于机载激光雷达冠层高度模型的小班区划

林业科学研究 2022年第2期35卷 28-36页

作者：熊昊庞勇荚文李春干中国林业科学研究院资源信息研究所国家林业和草原局林业遥感与信息技术重点实验室北京100091 广西大学林学院广西南宁530004

[目的]探究如何有效利用机载激光雷达冠层高度模型(chm)自动区划小班,提高小班区划工作效率。[方法]在高光谱影像树种信息的辅助下,使用机载激光雷达数据生成的chm进行两种空间尺度的分割和优化来自动区划小班。先对1 m空间分辨率chm数... 详细信息

[目的]探究如何有效利用机载激光雷达冠层高度模型(chm)自动区划小班,提高小班区划工作效率。[方法]在高光谱影像树种信息的辅助下,使用机载激光雷达数据生成的chm进行两种空间尺度的分割和优化来自动区划小班。先对1 m空间分辨率chm数据进行过分割,再对降尺度处理并平滑后的5 m空间分辨率chm数据进行欠分割,结合两种尺度分割结果并优化得到最终区划结果。将自动区划结果与人工区划小班、数字正射影像(DOM)屏幕勾绘小班以及主伐作业小班为三类参考小班对比,采用最终测量精度(UMA)准则的圆度(RO),紧致度(CO),形状指数(SI),最小包络圆短半径(RE),椭圆度(EF)和形状因子(P2A)8个指标,及自动区划小班与参考小班的交并比(IOU)指标,定量评价自动区划小班边界勾绘的准确程度。并利用样地实测数据和chm数据计算自动区划结果平均胸径、平均树高和冠层平均高的可解释性方差,验证自动区划结果的内部一致性和外部差异性精度。[结果]自动区划结果与参考小班的UMA形状、面积等特征较接近,与人工区划小班最相近。自动区划小班与人工区划、屏幕勾绘、主伐作业小班交并比大于70%的比例分别为46%,37%,43%,交并比大于50%的比例分别为61%,54%,55%。自动区划结果平均胸径可解释性方差为97%,平均树高可解释性方差为98%,和人工区划小班相同,说明其内部一致性高且和相邻小班差异大。冠层平均高可解释性方差为84.81%,比人工区划小班提高了1.77%。[结论]利用两种空间尺度的chm与高光谱树种分类图的分割和优化方法自动区划的小班在内部一致性及边界的精准度方面有明显优势,更符合小班边界处林木的分布情况,小班边界准确,且工作效率高,有助于森林的精细化管理。

关键词：机载激光雷达 chm 树种类别小班区划多尺度分割

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无脉络膜症家系致病变异的鉴定及机制研究

无脉络膜症家系致病变异的鉴定及机制研究

作者：冯贝中南大学

学位级别：硕士

研究背景:无脉络膜症(Choroideremia,chm)又称全脉络膜血管萎缩、进行性脉络膜萎缩、进行性毯层脉络膜萎缩。chm是一种罕见的伴X连锁的隐性遗传疾病。人群中发病率约为1/100000-1/50000,男性患者在青少年时期就表现出严重的视力损害,会... 详细信息

研究背景:无脉络膜症(Choroideremia,chm)又称全脉络膜血管萎缩、进行性脉络膜萎缩、进行性毯层脉络膜萎缩。chm是一种罕见的伴X连锁的隐性遗传疾病。人群中发病率约为1/100000-1/50000,男性患者在青少年时期就表现出严重的视力损害,会出现夜盲现象,随着年龄的增加周边视野逐渐丢失,视网膜色素上皮、光感受器和脉络膜进行性萎缩,晚期可能会失明。女性携带者一般不会表现出严重的视力损害,晚期可能视网膜、脉络膜出现斑片状萎缩。无脉络膜症发病的主要原因是chm基因突变导致编码的Rab escort protein-1(REP-1)蛋白功能缺失。REP-1参与Rab GTPase翻译后修饰(脂质修饰:异戊二烯化),Rab small GTPases(Rabs)是细胞内囊泡运输的关键调节因子,若缺失这种修饰,Rabs将无法参与细胞内的囊泡转运,会导致未异戊烯化的Rab蛋白聚集。已有研究表明,在无脉络膜症患者的淋巴细胞中发现Rab27a被低异戊烯化。多项研究表明RPE在chm发病机制中起着重要的作用,RPE细胞分泌的趋化因子IL-8、MCP-1增加,可能是chm患者眼部脉络膜内出现炎症细胞的原因,同时可能是少数chm患者视网膜和脉络膜新生血管发生的基础。研究目的:鉴定无脉络膜症家系的致病变异,并探究其致病机制。研究方法:本研究通过全外显子组测序、基因芯片及断裂点PCR,发现了无脉络膜患者chm基因上的突变c.314+216＿1167-14984delins TACCAAAGTC,该突变导致chm缺失852个核苷酸。随后构建了chm基因野生型和突变体质粒,并在HEK293细胞中进行过表达。免疫荧光检测REP-1蛋白的亚细胞定位以及与Rab27a的共定位情况;免疫印迹检测了野生型和突变体蛋白表达量、半衰期及降解途径;在ARPE19细胞中干扰chm基因的表达,ELISA检测ARPE19细胞分泌的趋化因子IL-8和MCP-1的量。研究结果:免疫荧光发现野生型和突变体在细胞膜上和细胞质中均有定位,在Hela细胞中重复与HEK293细胞中结果一致。免疫印迹结果显示突变体蛋白表达量明显低于野生型蛋白,发现突变体蛋白降解速率明显快于野生型,同时我们发现REP-1蛋白是通过蛋白溶酶体降解途径降解。本研究在HEK293细胞中共转了chm野生型和Rab27a以及突变体和Rab27a,并没有检测到突变会使Rab27a的定位发生改变。干扰ARPE19细胞中chm基因的表达,ELISA检测ARPE19细胞分泌的趋化因子IL-8和MCP-1的量没有明显变化。结论:chm基因的c.314+216＿1167-14984delins TACCAAAGTC为无脉络膜症家系的致病变异。该研究并未检测到突变对Rab27a定位的影响。沉默chm,ARPE19细胞分泌的IL-8和MCP-1的量没有明显改变。图21幅,表15个,参考文献43篇

关键词：无脉络膜症 chm 异戊烯化 Rab27a IL-8 MCP-1

Chinese herbal medicine resources: Where we stand

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Chinese Herbal Medicines 2020年第1期12卷 3-13页

作者： Ran-ran Gao Ya-ting Hu Yang Dan Li-jun Hao Xia Liu Jing-yuan Song Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China Engineering Research Center of Traditional Chinese Medicine Resource Ministry of EducationBeijing 100193China Yunnan Branch of Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeJinghong 666100China

In recent years,the development of Chinese herbal medicine(chm)has been challenged by shortages of chm resources and drug safety concerns related to end products.There have been significant efforts by Chinese scholars to tackle these challenges,which are revealed by analyzing the research trend of chm resources via surveying Chinese Traditional and Herbal Drugs(Zhong Cao Yao),a representative journal in chm.Our study focused on 781 articles in chm resources from 2013 to 2018 and included four subject areas:germplasm resources,quality analysis and evaluation,cultivation,and bioengineering of chm.Discussion and prospective for future investigations were also presented,including:construct the core germplasm of medicinal plants and expand germplasms;combine molecular research with field experiments and promote the deeper study of cultivation of chm plants;improve the quality evaluation method of chm and strengthen the identification of Chinese patented medicines;promote the sustainable development of chm resources by utilizing bioengineering and synthetic biology.This study helps international scholars understand the status quo of chm research and provides theoretical support for the healthy,modern,and international development of chm,and it will facilitate the sustainable development of the traditional Chinese medicine industry.

关键词： bioengineering cultivation chm resources germplasm resources identification quality analysis

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基于机载激光雷达的林隙结构参数提取

林业科学 2018年第10期54卷 98-107页

作者：李欢李明泽范文义王斌东北林业大学林学院哈尔滨150040

【目的】运用激光雷达技术识别提取林隙面积、边界木高和形状指数,为林隙结构参数调查提供技术支持。【方法】以机载激光雷达数据为数据源,以东北林业大学帽儿山实验林场内设置的5块林隙调查样地中的54个林隙为研究对象,通过对比普通克... 详细信息

【目的】运用激光雷达技术识别提取林隙面积、边界木高和形状指数,为林隙结构参数调查提供技术支持。【方法】以机载激光雷达数据为数据源,以东北林业大学帽儿山实验林场内设置的5块林隙调查样地中的54个林隙为研究对象,通过对比普通克里金插值、反距离权重插值、样条插值、自然临近插值和局部多项式插值确定最优插值方法得到冠层高度模型,运用交替贯序滤波法对冠层高度模型进行林隙识别提取。【结果】通过对比5种插值方法的RMSE发现,普通克里金法适合插值DEM,反距离权重法适合插值DSM;采用交替贯序滤波法识别提取林隙时,林隙识别率为92.6%,运用配对检验法对提取的林隙面积、边界木高与野外调查数据进行检验,基于激光雷达技术提取的林隙面积和边界木高与野外实测值呈较强线性关系,R^2分别为0.983和0.737,其中提取的林隙面积与实测值平均相对误差为15.78%,林隙边界木高与实测值平均相对误差为11.94%。【结论】基于机载激光雷达数据采用交替贯序滤波能有效识别林隙且能准确提取其结构参数;坡度、坡位及冠层结构复杂程度都会影响冠层高度模型的插值精度;林隙面积提取受林隙边界形状和林层结构影响,林隙边界木高随着样地地形、坡度增加误差也随之增大。机载激光雷达技术具有获取地形和树木三维结构信息的优势,可为林隙识别及其结构参数提取提供新的遥感方法。

关键词：机载激光雷达林隙结构参数数学形态学 chm

Review:Anticancer effects of Chinese herbal medicine,science or myth?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第12期7卷 1006-1014页

作者： RUAN Wen-jing LAI Mao-de ZHOU Jian-guang Department of Pathology School of MedicineZhejiang Universitv Hangzhou 310006 China Department of Dermatology the Second Affiliated Hospital School of Medieine Zhejiang University. Hangzhou 310009 China

Currently there is considerable interest among oncologists to find anticancer drugs in Chinese herbal medicine (chm). In the past, clinical data showed that some herbs possessed anticancer properties, but western scientists have doubted the scientific validity of chm due to the lack of scientific evidence from their perspective. Recently there have been encouraging results, from a western perspective, in the cancer research field regarding the anticancer effects of chm. Experiments showed that chm played its anticancer role by inducing apoptosis and differentiation, enhancing the immune system, inhibiting angiogenesis, reversing multidrug resistance (MDR), etc. Clinical trials demonstrated that chm could improve survival, increase tumor response, improve quality of life, or reduce chemotherapy toxicity, although much remained to be determined regarding the objective effects of chm in human in the context of clinical trials. Interestingly, both laboratory experiments and clinical trials have demonstrated that when combined with chemotherapy, chm could raise the efficacy level and lower toxic reactions. These facts raised the feasibility of the combination of herbal medicines and chemotherapy, although much remained to be investigated in this area.

关键词：中国草药抗癌药物肿瘤学 chm