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cf基因在梗阻性无精子症的研究进展

中国男科学杂志 1999年第4期13卷 242-243页

作者：曾国华梅骅中山医科大学附属第一医院泌尿外科广州510080

番茄叶霉菌及番茄抗性基因分子生物学研究进展

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园艺学报 2009年第6期36卷 911-922页

作者：芦丽亚杨宁赵凌侠上海交通大学农业与生物学院植物生物技术研究中心上海200240

叶霉菌(Cladosporium fulvum)是番茄(Solanum lycopersicum)叶霉病致病真菌,严重地威胁着番茄生产;二者互作遵循"基因对基因"假说,是目前研究植物与病原菌互作模式系统。本文简要地回顾了番茄叶霉菌和抗性基因(cf)研究历史;概述了叶霉... 详细信息

叶霉菌(Cladosporium fulvum)是番茄(Solanum lycopersicum)叶霉病致病真菌,严重地威胁着番茄生产;二者互作遵循"基因对基因"假说,是目前研究植物与病原菌互作模式系统。本文简要地回顾了番茄叶霉菌和抗性基因(cf)研究历史;概述了叶霉菌侵染特征、效应因子的类型、功能和特性;对番茄cf基因的类型、定位、进化、结构和功能研究进展加以综述,特别是对cf/Avr互作的分子机制、信号转导和抗性基因自激活等最新研究成果加以重点阐述;同时,对今后番茄抗叶霉病研究所面临问题、研究热点和解决策略进行了讨论。以期为番茄抗叶霉病或植物抗真菌病研究提供一些有用信息。

关键词：番茄叶霉菌 cf基因 Avr基因自激活蛋白

特发性胰腺炎ERCP的检查结果:囊性纤维化基因阳性及阴性患者

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世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 36-37页

作者： Alazmi W.M. Fogel E.L. Schmidt S. G.A. Lehman 张欣 Indiana University Medical Center 550 N. University Blvd Indianapolis IN 46202 United States Dr.

Abstract Abstract Background: Our series of patients with idiopathic pancreatitis (IP) found a cystic fibrosis (cf) gene abnormality in 19% compared with 3.5% in patients without pancreatitis. Objective: The objective was to determine whether the cf gene predicts more severe ERP findings. Design: This was a retrospective case-control study. Setting and Patients: From July 1998 to August 2004, cf gene analysis was performed in 819 patients with IP via Genzyme Genetics. The panel tests for 70 to 87 alleles and has a detection rate of more than 90% of the cases. Sixty-nine patients (8.4% ) who had at least one cf gene positive mutation were the study cohort. A total of 218 patients with IP and negative cf gene mutation were randomly selected from our database to be in the control group. Main Outcome Measurements: Pancreatograms were evaluated for chronic pancreatitis (CP) based on Cambridge criteria. The results of the gene analysis were not available at the time of pancreatogram interpretation. Results: Among patients positive for the cf gene, 42 (61% ) were women. The mean age at intervention was 40 years (range 14-80 years), and 48 patients (70% ) had cholecystectomy. Among patients who were negative for the cf gene, 147 (67% ) were women. The mean age at intervention was 41 years (range 9-89 years), and 125 patients (57% ) had cholecystectomy. Compared with controls, cases had higher incidence of CP (62% vs. 48% , p = 0.05), grade III CP (35% vs. 18% , p = 0.004), pseudocysts (12% vs. 4% , p = 0.036) and pancreatic strictures (20% vs. 8% , p = 0.008). Limitations: The limitations of the study were (1) retrospective design and (2) the panel used tests only for 70 to 87 alleles (of approximately, 900 cf transmembrane conductance regulator genes known). Conclusions: The mean age at intervention in both groups was similar. CP, grade III CP, pseudocysts, and pancreatic strictures were more common among patients who were cf gene positive.

关键词：慢性胰腺炎阴性患者囊性纤维化基因异常检查结果特发性阳性 ERCP cf基因胆囊切除术

高温高湿协同抑制cf-4/Avr4和cf-9/Avr9介导的HR

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高温高湿协同抑制Cf-4/Avr4和Cf-9/Avr9介导的HR