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Human mesenchymal stromal cells enhance the immunomodulatory function of cd8＋cd28- regulatory t cells

Cellular & Molecular Immunology 2015年第6期12卷 708-718页

作者： Qiuli Liu Haiqing Zheng Xiaoyong Chen Yanwen Peng Weijun Huang Xiaobo Li Gang Li Wenjie Xia Qiquan Sun an Andy Peng Xiang Cell-gene therapy translational Medicine Research Center The Third Affiliated Hospital Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong China Center for Stem Cell Biology and tissue Engineering The Key Laboratory for Stem Cells and Tissue Engineering Ministry of Education Sun Yat-sen University Guangzhou China Department of Rehabilitation Medicine The Third Affiliated Hospital Sun Yat-sen University Guangzhou China Institute of Blood transfusion Guangzhou Blood Centre Guangzhou China Department of Renal transplantation The Third Affiliated Hospital Sun Yat- sen University Guangzhou China Department of Biochemistry Zhongshan Medical School Sun Yat-sen University Guangzhou China these authors contributed enuallv tn this wnrk

One important aspect of mesenchymal stromal cells （MSCs）-mediated immunomodulation is the recruitment and induction of regulatory t （treg） cells. However, we do not yet know whether MSCs have similar effects on the other subsets of treg cells. Herein, we studied the effects of MSCs on cd8＋cd28- treg cells and found that the MSCs could not only increase the proportion of cd8＋cd28- t cells, but also enhance cd8＋cd28-t cells＇ ability of hampering naive cd4＋ t-cell proliferation and activation, decreasing the production of IFN-γ by activated cd4＋ t cells and inducing the apoptosis of activated cd4＋ t cells. Mechanistically, the MSCs affected the functions of the cd8＋cd28- t cells partially through moderate upregulating the expression of IL-10 and FasL. the MSCs had no distinct effect on the shift from cd8＋cd28＋ t cells to cd8＋cd28- t cells, but did increase the proportion of cd8＋cd28- t cells by reducing their rate of apoptosis. In summary, this study shows that MSCs can enhance the regulatory function of cd8＋cd28- treg cells, shedding new light on MSCs-mediated immune regulation.

关键词： antigens cd28 cd8-positive t cells mesenchymal stromal cells regulatory t cells

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