检索结果-南通市图书馆

Correlation Analysis on Total Lymphocyte count and cd4 count in HIV-infected Patients: A Retrospective Evaluation

Journal of Huazhong University of Science and Technology(Medical Sciences) 2011年第5期31卷 712-716页

作者：王宇明梁淑英于二曼郭金玲李自钊王哲杜玉开 Henan Provincial Medical Academy Department of Epidemiology and Biostatistics College of Public Health Zhengzhou University Center for AIDS/STD Control and Prevention Department of Health of Henan Province Institute for Infection Disease Control and Prevention Henan Provincial Center for Disease Control and Prevention Department of Maternal and Child Health Care and Adolescent Hygiene School of Public Health Tongji Medical College Huazhong University of Science and Technology

cd4 count is the standard method for determining eligibility for highly active antiretroviral therapy （HAART） and monitoring HIV/AIDS disease progression, but it is not widely available in resource-limited settings. This study examined the correlation between total lymphocyte count （TLC） and cd4 count of HIV-infected patients before and after HAART, and assessed the thresholds of TLC for making decisions about the initiation and for monitoring HAART. A retrospective study was performed, and 665 HIV-infected patients with TLC and cd4 count from four counties （Shangcai, Queshan, Shenqiu and Weishi） were included in the study. Pearson correlation and receiver operating characteristic （ROC） were used. TLC and cd4 count after HAART was significantly increased as compared with pre-HAART （P〈0.01）. An overall positive correlation was noted between TLC and cd4 count （pre-HAART, r=0.73, P=0.0001; follow-up HAART, r=0.56, P=0.0001）. The ROC curve between TLC and cd4 count showed that TLC ≤ 1200 cells/mm3 could predict cd4 〈 200 cells/mm3 with a sensitivity of 71.12%, specificity of 66.35% at pre-HAART. After 12-month HAART, the optimum prediction for cd4 count 〈 200 cells/mm3 was a TLC ≤ 1300 cells/mm3, with a sensitivity of 63.27%, and a specificity of 74.84%. Further finding indicated that TLC change was positively correlated to cd4 change （r=0.77, P=0.0001） at the time point of 12-month treatment, and the best prediction point of TLC change for cd4 increasing was 135 cells/mm3. TLC and its change can be used as a surrogate marker for cd4 count and its change of HIV-infected individuals for making decisions about the initiation and for monitoring HAART in resource-limited settings.

关键词： HIV/AIDS cd4 count total lymphocyte count highly active antiretroviral therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

HIV-1 RNA Viral Load, cd4 count and Some Haematological Parameters of People Living with HIV in the Enugu Metropolis

引用

World Journal of AIDS 2023年第2期13卷 57-69页

作者： Izuchukwu Ibeagha Evelyn Ada Kyrian-Ogbonna Felix Emelike Ekene Ibeagha Emmanuel Enyi Theresa Osarunwese Ifeyinwa Onochie-Igbinedion Harrison Abone Dorothy Ezeagwuna Chinwe Chukwuka Moses Ikegbunam Anti-Retroviral Therapy (ART) Laboratory University of Nigeria Teaching Hospital Ituku Enugu Nigeria APIN Public Health Initiative Makurdi Nigeria Department of Applied Microbiology and Brewing Nnamdi Azikiwe University Awka Nigeria Medical Laboratory Department Ambrose Alli University Ekpoma Nigeria Center for Clinical Care and Clinical Research of Nigeria (CCRN) Makurdi Nigeria Department of Pharmaceutical Microbiology and Biotechnology Nnamdi Azikiwe University Awka Nigeria Department of Parasitology and Entomology Nnamdi Azikiwe University Awka Nigeria Molecular Research Foundation for Students and Scientists (MRFSS) Nnamdi Azikiwe University Awka Nigeria

Background: It is widely known that the human immune-deficiency virus (HIV) induces biochemical and physiological changes in affected persons. Consequently, the overall aim of this study was to evaluate the HIV-1 RNA viral load, cd4 count, and certain haematological parameters among HIV treatment-na?ve subjects in the Enugu metropolis of Nigeria. Materials and Methods: A total of 252 HIV-infected, ART-native subjects (≥18) attending the University of Nigeria Teaching Hospital (UNTH) in Ituku-Ozalla, Enugu were recruited for this study and were made up of 157 (62.3%) females and 95 (37.7%) males. A total of 250 HIV-negative subjects were used as control subjects (100 males and 150 females). Blood samples were collected from all the participants and their HIV-1 status was confirmed by an immunoblot confirmatory test. Their haematological parameters and cd4 count were evaluated, while the HIV-1 viral load was only assessed on confirmed HIV-positive subjects. Results: There was female predominance (62.3%) among these HIV-positive subjects. The mean age of HIV-positive subjects was 39.16 ± 10.08 years while the mean age of the control subjects was 34.8 ± 8.6 years. The age group of 31 - 40 years (102/252 (40.5%)) constituted most of the test subjects. The total white blood cells (TWBC) (6.05 ± 5.46), lymphocyte counts (36 ± 14), haemoglobin concentrations (Hb) (9.85 ± 7.36) and the cd4 counts (242 ± 228) of the HIV-infected subjects showed a significant difference when compared with their control counterpart values of TWBC (4.5 ± 0.568), lymphocytes (39.67 ± 8.2), Hb (13.48 ± 1.5), and cd4 counts (807 ± 249) (p 0.05). Anaemia, lymphocytopenia, and thrombocytopenia were the haematological abnormalities seen in the HIV-positive subjects. HIV viral load correlated with haemoglobin concentration, cd4 count, lymphocyte count, and neutrophil count (p Conclusion: Prognostic factors, such as haemoglobin concentrations, cd4 counts, lymphocyte counts, and neutrophil counts can be

关键词： HIV-1 RNA cd4 count Haematological Parameters

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correlation of Whole Blood Zinc Levels,cd4 Cell count,Disease Stage,and Dermatologic Manifestations Among HIV Patients:A Single Center Experience in Philippines

引用

International Journal of Dermatology and Venereology 2023年第1期6卷 25-28页

作者： Riza I.Sarne Ma.Teresita G.Gabriel Emmerson Gale S.Vista Maria Jenina P.Aguado Cynthia Angela Karim Department of Dermatology Research Institute for Tropical MedicineAlabangMuntinlupaMetro Manila 1781Philippines

Objective:Zinc deficiency is the most common micronutrient abnormality seen in human immunodeficiency virus(HIV)*** of cd4 cells is a hallmark of HIV *** study aims to determine the association between whole blood zinc levels and cd4 cell count and stage of HIV infection among patients in a tertiary hospital in the ***:Sixty-five newly diagnosed HIV-positive patients of the institution were *** profile,whole blood zinc levels,cd4 cell count level,HIV disease stage,and presence of any dermatologic manifestations were *** of zinc deficiency and correlation between whole blood zinc levels and cd4 cell count were *** data were analyzed by chi-square and pearson correlation ***:Among the 65 patients,overall zinc deficiency was noted at 33.8%.Low cd4 count and HIV disease stage IV participants had the highest percentage of zinc deficiency at 54.6%and 50%,respectively.A correlation coefficient atr=0.3364 was noted between whole blood zinc levels and cd4 cell count(P=0.006).Twenty-nine patients presented with dermatologic manifestations,with 10 patients being zinc ***:A weak positive correlation was seen between zinc levels and cd4 *** is an increasing frequency of zinc level deficiency with a higher HIV disease *** manifestations of HIV may be present in both patients with normal and deficient zinc levels.

关键词： HIV cd4 count zinc level disease stage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Profiles of HIV-infected anti-retroviral therapy naïve children from Mumbai,India

引用

World Journal of Pediatrics 2016年第4期12卷 430-435页

作者： Supriya Mayur Paranjpe Purva Pankaj Sarkate Nayana Avinash Ingole Shweta Sadanand Raut Preeti Rajeev Mehta Department of Microbiology 5th floorMulti-Storey BuildingSeth G.S.Medical College and K.E.M.HospitalParelMumbaiIndia

Background:This study aimed to investigate the demographic profiles of human immunodifficiency virus(HIV)infected anti-retroviral therapy(ART)naïve children in our hospital and their relations to the clinical,immunological and nutritional ***:A cross-sectional study was conducted in an Integrated Counselling and Testing Center(ICTC)at a tertiary care hospital in *** naïve HIV positive children were enrolled in the *** demographic profiles,clinical features,immunological(cd4%/cd4 count)and nutritional status of these children were *** agreement between clinical,immunological and nutritional staging was determined using Cohen’s kappa ***:In 192 HIV-infected ART naive children enrolled with a median age of 9 years(range 3 months-14 years),97.4%acquired infection through vertical *** most common clinical presentation was fever(39.6%),followed by generalized lymphadenopathy(32.3%),cough(22.4%)and diarrhoea(9.9%).Tuberculosis was seen in 22.9%of the *** agreement was fair between clinical and immunological staging,and slight between nutritional,immunological and clinical ***:Perinatal transmission is the most common mode of acquiring HIV infection in *** Prevention of Parent to Child Transmission(PPTCT)program should be strengthened for lowering the transmission rate by providing extended ART to mothers during pregnancy and *** remains a major concern in HIV-infected *** poor correlation between WHO clinical and immunological staging emphasizes the importance of making cd4 facilities available in HIV prevalent *** cannot be used as a surrogate marker for predicting stage or severity as it is common at all stages of HIV disease.

关键词： anti-retroviral therapy cd4 count clinical stage HIV nutritional status

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Retinal manifestations of patients with human immun- odeficiency virus, a multiethnics study in Malaysia

引用

International Journal of Ophthalmology(English edition) 2011年第6期4卷 641-643页

作者： Loo A.V.P Sujaya S Peyman M Florence S Subrayan V Department of Ophthalmology University of Malaya

· AIM: To investigate the fundus findings of patients infected with human immunodeficiency virus (HIV) in correlation to Highly Active Antiretroviral Therapy (HAART) and cd4 count. · METHODS: Two hundred and two patients of the three major races (Chinese, Malay and Indian) in Malaysia were recruited in this population-based cross-sectional study. This consisted of confirmed HIV sero-positive patients with HAART treatment (n=95) or without HAART therapy (n=107) from December 2007 to March 2008. They were further classified into the HIV infected group, AIDS related complex (ARC) group and AIDS group. Each group was then subdivided according to their cd4 count. Clinical fundus findings were recorded. · RESULTS: Sixty six patients (32.7%) showed presence of fundus manifestation, majority of which was HIV microangiopathy (89%) and the rest being Cytomegalovirus (CMV) retinitis (11%). The most common fundus lesion was cotton wool spot (34%). There was a higher incidence of fundus manifestation in the non HAART group than the HAART group (P =0.04) and in patients with cd4 count less than 200 cells/ml in both groups (P =0.01). The HAART therapy had remarkably reduced the percentage of fundus manifestation by 20% but cd4 count remains the marker for fundus manifestations. There were no significant differences noted in the retinal manifestation among the different races. (ANOVA, P =0.25). · CONCLUSION: The fundus manifestations were higher in patients with cd4cd4 count determines the occurrence of fundus manifestations. ·

关键词： HIV fundus manifestations CMV retinitis HAART cd4 count

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：