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A reversed cd4/cd8 ratio of tumor-infiltrating lymphocytes and a high percentage of cd4^(+)FOXP3^(+) regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix

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Cellular & Molecular Immunology 2011年第1期8卷 59-66页

作者： Walayat Shah Xiaofei Yan Li Jing Yi Zhou Hongwei Chen Yili Wang Center for Cancer Research First Affiliated HospitalXi’an Jiaotong UniversityXi’anChina Institute of Basic Medical Sciences Khyber Medical UniversityPeshawarKhyberPakhtoonkhwaPakistan Department of Biochemistry School of MedicineXi’an Jiaotong UniversityXi’anChina Department of Pathology Ningxia Medical UniversityYinchuanChina Department of Pathology Xi’an Medical CollegeXi’anChina

In this study,40 biopsy samples collected from cervical cancer patients at the First Affiliated Hospital of Xi’an Jiaotong University,China,were retrospectively assessed using immunohistochemistry for cd4^(+) and cd8^(+) tumor-infiltrating lymphocytes(TILs)and were analyzed for the expression of FOXP3,OX40,granzyme B(GrB)and perforin(Prf).The proliferating index of the TILs was determined by assessing Ki67 *** determined the prognostic value of low and high numbers of TILs on survival by performing Kaplan–Meier analysis using median values as the cut-off *** for the number of cd4^(+)FOXP3^(+) regulatory T cells(Tregs)and the cd4/cd8 ratio,none of the cd4^(+),cd8^(+),OX401,GrB^(+) or Prf^(+) TILs were associated with the overall 5-year survival *** 5-year survival rate was significantly lower in patients who had a high percentage of Tregs as compared with the those who had a lower percentage(35.3%versus 88.9%,P50.001),while the 5-year survival rate was significantly higher in patients with a high cd4/cd8 ratio as compared with patients who had a low cd4/cd8 ratio(82.4%versus 44.4%,P50.029).When we considered the deaths and surviving cases as separate groups,we found that both the number of cd4^(+) T cells and the cd4/cd8 ratio were significantly lower in patients who died as compared with those who survived(26.33±11.80 versus 47.79±38.18,P=0.023 and 0.60±0.25 versus 1.17±1.02,P=0.019,respectively).In conclusion,decreased proportions of tumor-infiltrating cd4^(+) T cells with high percentages of Tregs and reversed cd4/cd8 ratios were significantly associated with the clinical outcome of patients with cervical carcinoma.

关键词： cd4/cd8 ratio cervical carcinoma clinical outcome tumor-infiltrating lymphocytes

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Longitudinal analysis of immune reconstitution and metabolic changes in women living with HIV:A real-world observational study

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Chinese Medical Journal 2023年第18期136卷 2168-2177页

作者： Xiaolei Wang Jiang Xiao Leidan Zhang Ying Liu Na Chen Meiju Deng Chuan Song Tingting Liu Yuanyuan Zhang Hongxin Zhao Clinical and Research Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Institute of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China National Center for Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Infection Beijing Ditan HospitalPeking UniversityBeijing 100015China

Background:Women comprise more than half of people living with human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS)worldwide and incomplete immune recovery and metabolic abnormalities affect them *** of HIV antiretroviral therapy(ART)have a low female representation in *** aimed to investigate immune reconstitution and metabolic changes of female HIV-positive cohort in China ***:HIV-positive women who initiated ART from January 2005 to June 2021 and were followed up regularly at least once a year were included in this *** indicators(cluster of differentiation 4[cd4]counts and cd8 counts),viral load(VL),and metabolic indicators were collected at *** data were collected from the China Disease Prevention and Control Information System(cdPCIS).VL was tested half a year,1 year after receiving ART,and every other year subsequently according to local ***4/cd8 ratio normalization was considered as the primary outcome and defined as a value≥*** rate and probability of cd4/cd8 ratio normalization were estimated through per 100 person-years follow-up(PYFU)and Kaplan-Meier curve,*** Cox regression was used to identify independent risk factors associated with cd4/cd8 ratio *** further studied the rate of dyslipidemia,hyperuricemia,diabetes,liver injury,and renal injury after ART initiation with the chi-squared tests or Fisher’s exact probability tests,and a generalized estimating equation model was used to analyze factors of dyslipidemia and ***:A total of 494 female patients with HIV/AIDS started ART within 16 years from January 2005 to June 2021,out of which 301 women were enrolled with a median duration of ART for 4.1 years(interquartile range,2.3-7.0 years).The overall incidence rate of cd4/cd8 ratio normalization was 8.9(95%confidence interval[CI],7.4-10.6)per 100 PYFU,and probabilities of cd4/cd8 normalization after initiatin

关键词： Women Human immunodeficiency virus Immune reconstitution cd4/cd8 ratio HIV

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Disease Progression Patterns of SHIV-KB9 in Rhesus Macaques of Chinese Origin in Comparison with Indian Macaques

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Biomedical and Environmental Sciences 2008年第4期21卷 302-307页

作者： QIANG LIU GUI-BO YANG HUI ZHAO QIANG WEI HUI XING CHUAN QIN YI-MING SHAO State Key Laboratory for Infectious Diseases Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences （CAMS） and Peking Union Medical College （PUMC） Beijing 100021 China

Objective To develop a model of SHIV-KB9/Chinese origin rhesus （Ch Rh） macaques for vaccine research and to compare the pathogenesis of SHIV-KB9 in Ch Rh macaques with that reported in Indian rhesus （Ind Rh） macaques. Methods Seven mamu-A＊01 negative Ch Rh macaques were inoculated intravenously with 1-10000 MID50 of SHIV-KB9. The monkeys were monitored for viral load, cd4, cdS, SHIV-specific antibody and virus genetic variation. The results were compared with those previously observed in Ind Rh macaques. Results As compared to that observed in Ind Rh macaques, SHIV-KB9 in Ch Rh macaques displayed three identical disease progression patterns. However, the primary pattern was not identical between the two subspecies. The level of plasma viremia differed in SHIV-KB9-infected Ch Rh macaques which exhibited different outcomes from those in Ind Rh macaques. Generally, the values of viral load and the maintenance of cd4^＋ T cells were associated with humoral responses. Otherwise, the viral genetic distances （divergence, diversity） were larger in animals （M419, M425） with their cd4^＋ T cells profoundly depleted. Conclusion The model of SHIV-KB9/Ch Rh macaques displays a relatively slow progression to AIDS compared with Ind Rh macaques, which may more accurately reflect the potential of candidate vaccines in humans.

关键词： SHIV-KB9 Rhesus macaque Subspecies Viral load cd4/cd8 ratio Antibody titer Gene variation

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Autoimmune thrombocytopenia in response to splenectomy in cirrhotic patients with accompanying hepatitis C

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World Journal of Gastroenterology 2006年第8期12卷 1205-1210页

作者： Tetsuro Sekiguchi Takeaki Nagamine Hitoshi Takagi Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashiJapan School of Health Sciences Gunma University Graduate School of MedicineMaebashiJapan

AIM： To estimate the contribution of autoimmune thrombocytopenia to hepatitis C virus-related liver cirrhosis （type C cirrhosis）, we evaluated the influence of splenectomy upon platelet-associated immunoglobulin G （PAIgG） levels and platelet numbers. METHODS： PAIgG titers and immune markers were determined in 24 type C cirrhotic patients with an intact spleen, 17 type C cirrhotic patients submitted to splenectomy, and 21 non-C cirrhosis with an intact spleen. RESULTS： Thrombocytopenia （PLT〈15×10^4/μL） in type C cirrhosis was diagnosed in all patients with an intact spleen, 8 patients submitted to splenectomy, and in 19 non-C cirrhosis with intact spleen. Elevated titers of PAIgG at more than 25.0 ng/107cells were detected in all cirrhotic patients except for one splenectomized patient. PAIgG titers （ng/10^7cells） were significantly higher in the type C cirrhosis with an intact spleen （247.9 ± 197.0） compared with the splenectomized patients （125.6±87.8） or non-C cirrhosis （152.4± 127.4）. PAIgG titers were negatively correlated with platelet counts in type C cirrhotic patients with an intact spleen. In comparison with the type C cirrhosis with an intact spleen, the splenectomized patients had a reduced cd4/cd8 ratio and serum neopterin levels. The spleen index （cm^2） was negatively correlated with platelet counts in the non-C cirrhosis, but not in the type C cirrhosis. CONCLUSION： Our data indicate that the autoimmune mechanism plays an important role in thrombocytosis complicated by HCV-positive cirrhosis. In addition, splenectomy may impair T cells function through, at least in part, a reduction of cd4/cd8 ratio, consequently suppressing PAIgG production.

关键词： Platelet-associated immunoglobulin G Autoimmune thromboo/topenia Liver cirrhosis Hepatitis C virus Splenectomy cd4/cd8 ratio

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