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Primary cutaneous anaplastic large cell lymphoma with subsequent leg involvement

World Journal of Dermatology 2012年第3期1卷 38-40页

作者： Mitsuaki Ishida Norikazu Fujii Hidetoshi Okabe Division of Diagnostic Pathology Department of Clinical Laboratory Medicine Shiga University of Medical Science Shiga 520-2192 Japan Department of Dermatology Shiga University of Medical Science Shiga 520-2192 Japan

Primary cutaneous anaplastic large cell lymphoma(CALCL)is regarded as an indolent type of cutaneous T-cell ***,a few recent publications revealed that C-ALCL patients with initial leg involvement had significantly worse survival than those without initial leg ***,we report a case of C-ALCL with subsequent leg involvement,which led to death after chemoradiation therapy.A 75 years old Japanese man presented with multiple erythematous nodules in his left arm and the side of his left *** and immunohistochemical studies led to the diagnosis of primary *** the initial diagnosis,no leg lesion was *** year after the initial diagnosis,C-ALCL appeared in his right lower thigh and left *** therapy,low-dose etoposide and CHOP therapy were performed;however,the patient died of malignant lymphoma 4 years after the initial *** speculated that the occurrence of subsequent leg involvement may also be indicative of a worse prognosis,as in the case with initial leg involvement in ***,we propose that C-ALCL patients with initial or subsequentleg involvement should be classified as a distinct clinicopathological variant of C-ALCL("leg-type"involvement)and that they may require intense therapy.

关键词： Cutaneous lymphoma Cutaneous cd30-positive T-cell lymphoproliferative lesion Primary cutaneous anaplastic large cell lymphoma Leg involvement Prognosis Chemotherapy

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