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Induction of acute hepatic injury by endotoxin in mice

Hepatobiliary & Pancreatic Diseases International 2002年第4期1卷 558-564页

作者： Xie G.-Q. Jiang J.-X. Chen Y.-H. Liu D.W. Zhu P.-F. Wang Z.-G. Emergency Department 152nd Hospital PLA Pingdingshan 467000 China Research Institute of Surgery Daping Hospital Third Military Medical University Chongqing 400042 China

Objective: To investigate the changes of scavenger re-ceptor （SR） and cd14 in Kupffer cells in endotox-emia in order to uncover the mechanism of the liverto turn a defense organ into effector one in ***: Mouse models of endotoxemia of differentseverity were reproduced by injection of different do-ses of lipopolysaccharide （LPS） via the tail *** expression of SR and cd14 in the liver was as-sayed by immunohistochemistry and was subsequent-ly analyzed with an image analysis system. The levelsof TNF-α and IL-6 in liver tissue were determinedwith ***: The expression of SR in the liver in the high-dose group was markedly decreased one hour afterinjection of LPS, and also in the low-dose group at 3hours. The expression of SR in the liver in the twogroups was shown to be progressively decreased withthe time prolonged. There was significant differencein average optical density （OD） values of SR be-tween the two groups. The expression of cd14 in thetwo groups was shown to be significantly increasedone hour after injection of LPS, and more signifi-cantly with the time prolonged. But there was no sig-nificant difference in OD values of cd14 between thetwo groups. The contents of intrahepatic proinflam-matory mediators TNF-α, IL-6, ALT and TBILwere significantly increased after injection of *** analysis revealed that the changes ofTNF-α, IL-6, ALT, and TBIL were negatively cor-related with the expression of SR, and positively withthe expression of cd14.Conclusion: The up-regnlation of cd14 expressionand down-regulation of SR expression on Kupffercells might be one of the important mechanisms forthe conversion of Kupffer cells from immune defen-sive to inflammatory response cells in acute hepaticinjury.

关键词： hepatic injury endotoxemia scavenger receptor cd14 tumor necrosis factor-α interleukin

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