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应用Micro CT观察洛伐他汀和秋水仙碱对ccl_4致肝损伤后小鼠骨代谢的影响

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中国药理学通报 2014年第8期30卷 1116-1122页

作者：吕思敏于琼夏海珊崔燎吴铁广东医学院药学院广东东莞523808 广东天然药物研究与开发重点实验室广东湛江524023

目的本实验应用Micro CT研究洛伐他汀和秋水仙碱对ccl4致肝损伤后小鼠骨代谢的影响,并比较二者的效果。方法体积分数40%的ccl4花生油皮下注射,建立小鼠肝损伤模型,同时,洛伐他汀按2.6 mg·kg-1,秋水仙碱按0.065 mg·kg-1每天1次灌胃给药... 详细信息

目的本实验应用Micro CT研究洛伐他汀和秋水仙碱对ccl4致肝损伤后小鼠骨代谢的影响,并比较二者的效果。方法体积分数40%的ccl4花生油皮下注射,建立小鼠肝损伤模型,同时,洛伐他汀按2.6 mg·kg-1,秋水仙碱按0.065 mg·kg-1每天1次灌胃给药,连续1个月,于实验结束后观察肝损伤血清学指标以及肝匀浆相关的抗氧化指标,并用Micro CT测定小鼠胫骨骨组织结构参数。结果单用ccl4小鼠肝指数明显增加,AST和ALT活性明显升高,肝匀浆中SOD活性和GSH-Px水平明显降低,MDA水平明显升高,且胫骨上段骨组织结构参数BVF、TMD值明显降低,SMI值明显升高,出现明显的骨质疏松症状。而洛伐他汀、秋水仙碱用药后对肝损伤没有明显影响,但洛伐他汀对肝损伤导致的骨丢失有明显的保护作用,秋水仙碱组则没有明显的保护作用。结论 ccl4致肝损伤后的小鼠出现骨质疏松症状,洛伐他汀用药后对ccl4致肝损伤的骨丢失有明显的预防作用。

关键词： Micro CT 洛伐他汀秋水仙碱 ccl_4 肝损伤骨质疏松

Trapping of the Dichlorocarbene Intermediate in the Reaction of α-Cyanobenzyl carbanion with Carbon Tetrachloride

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Chinese Chemical Letters 1998年第10期9卷 895-896页

作者： Jin Pei CHENG Zi Rong ZHENG(Department of Chemistry, Nankai University, Tianjin 300071) Department of Chemistry Nankai University Tianjin 300071 China

In Me2SO, an X-philic reaction took place between α-cyanobenzyl carbanion and ccl4. The intermediate dichlorocarbene was trapped by the primary product dicyanostilbene to give the alkene-carbene adduct, 1, 1-dichloro... 详细信息

关键词： dichlorocarbene S_N2vs. ET mechanism ccl_4

Hepatoprotective and antioxidant capacity of Melochia corchorifolia extracts

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Asian Pacific Journal of Tropical Medicine 2013年第7期6卷 537-543页

作者： B Ganga Rao Y Venkateswara Rao T Mallikarjuna Rao A.U College of Pharmaceutical Sciences Andhra UniversityVisakhapatnamAndhra PradeshIndia-530003 Department of Botany College of Science and TechnologyAndhra University.VisakhapatnamAndhra PradeshIndia-530003

Objective:To evaluate bepato protective and antioxidant capacity of Melochia corchorifolia （***）aerial part ***:Antioxidant activitywas evaluated by using three free radicals（Superoxide,Hydroxyl and DPPH） and hepatoprotective activity was assessed against ccl4 induced liver intoxication in ***:The extracts produced concentration dependent percentage protection in decrease of serum enzymes and percentage inhibition on free *** all extracts methanol extract showed better activity with percentage protection of SGOT（78.98%）,SGPT（79.65%）,ALP（82.48%） and total bilirubin（80.0%）levels against ccl4 liver intoxication and also methanolic extract showed better activity with IC50 values on superoxide. hydroxyl and DPPH radicals were 127μg.240μg and 179μ***:From the results obtained during the study it could be concluded that *** aerial part extracts have antioxidant and hepaloprotective *** study is necessary for isolation and characterization of bioactive molecules which are responsible for hepatoprotective and antioxidant activity.

关键词： Melochia corchorifolia Aerial parts Free radicals Antioxidant Activity ccl_4 Hepatoprotective activity

Medicinal plants with hepatoprotective activity in Iranian folk medicine

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Asian Pacific Journal of Tropical Biomedicine 2015年第2期5卷 146-157页

作者： Majid Asadi-Samani Najme Kafash-Farkhad Nafiseh Azimi Ali Fasihi Ebrahim Alinia-Ahandani Mahmoud Rafieian-Kopaei Medical Plants Research Center Shahrekord University of Medical Sciences Department of Biology Faculty of ScienceUrmia University Department of Biology Science and Research BranchIslamic Azad University Department of Genetics Faculty of Biology ScienceTarbit Modares University

There are a number of medicinal combinations in the Iranian traditional medicine which are commonly used as tonic for *** this review,we have introduced some medicinal plants that are used mainly for the treatment of liver disorders in Iranian folk medicine,with focus on their hepatoprotective effects particularly against CCI_4 *** this study,online databases including Web of ***,and Science Direct were searched for papers published from January 1970 to December *** terms consisted of medicinal plants,traditional medicine,folk medicine,***,liver,therapeutic uses,compounds,***_***-inflammatory,and antihepatotoxic,hepatitis,alone or in *** hirtifolium Boiss..Apium graveolens L..Cynara *** vulgaris L..,Calendula officinalis,Nigella sativa L..Taraxacum *** *** ferulacea L..Allium sativum,Marribium vulgare,Ammi majus L..Citrullus lanatus *** eupatoria *** Primus armeniaca *** some of the medicinal plants that have been used for the treatment of liver disorders in Iranian folk *** of several leads obtained from plants containing potential hepatoprotective agents,silymarin,P-sitosterol,betalain,***,and glycyrrhizin have been demonstrated to have potent hepatoprotective *** encouraging data on possibility of new discoveries in the near future,the evidence on treating viral hepatitis or other chronic liver diseases by herbal medications is not adequate.

关键词： Medicinal plants Iran Compounds Liver Therapeutic uses ccl_4

Hepatoprotective activity of Hepax-A polyherbal formulation

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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 142-146页

作者： VC Devaraj B Gopala Krishna GL Viswanatha Jagadish V Kamath Sanjay Kumar Department of Pharmacology Krupanidhi College of Pharmacy Department of Pharmacognosy RR College of Pharmacy Department of Pharmacology PES College of Pharmacy

Objective:To evaluate the hepatoprotective potential of Hepax,a polyherbal formulation,against three experimentally induced hepatotoxicity models in ***:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models,namely, carbon tetrachloride(ccl_4),paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins(ccl_4,paracetamol and thiocetamide) showed significant morphological,biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters(liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters(SGPT,SCOT,ALP and total bilirubin),which were evidently showed in histopathological ***:The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg,*** the liver of all the three experimental animal models.

关键词： Hepax Paracetamol ccl_4 Thiocetamide Hepatotoxicity

Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa

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Asian Pacific Journal of Tropical Biomedicine 2011年第5期1卷 348-352页

作者： Sundaram Ravikumar Murugesan Gnanadesigan chool of Marine Sciences Department of Oceanography and Coastal Area Studies.Alagappa University

Objective:To identify the hepatoprotective and in vitro antioxidant activity of Lumnitzera racemosa(***) leaf ***:Animals in Group 1 served as vehicle control. Group 2 served as hepatotoxin(ccl_4 treated) *** 3 served as positive control(Silyntarin) group,and Group 4.S and ft served as(73,150 and 300 nig/kg bw p.o.)*** leaf extract treated ***,in vitro antioxidant DPPH,hydroxyl radical scavenging activity(HRSA),NO,ferric reducing antioxidant power(FRAP),lipid hydroperoxide(LPO) and super oxide dismutase(SOD) were also analyzed for the leaf ***:The levels of the serum parameters such as serum glutamic oxaloacetic transaminase(SGOT).serum glutamic pyruvic transaminase(SGPT).alkaline phosphatase(ALP),bilirubin,cholesterol(CHL).sugar and lactate dehydrogenase(LDH) were significantly increased in COL_4 treated rats when compared with the control group(P4.3)IU/L],bilurubilt[(2.13 ±0.84) mg/dL].cholesterol[(163.83± 13.63) mg/dL].sugar[(93.00±7.63) mg/dL]and LDH[(1134.00) ±285.00)IU/L]were observed with the high dose(300 mg/kg bw) of leaf extract treated rats. Histopathological scores showed that,no visible changes were observed with high dose(300 mg/ kgbw) of leaf extract treated rats except few mild *** IC_(50) values were observed as(56.37 ±4.87)μg/mL,(57.68±1.98) μg/mL,(64.15±2.90)μg/mL,(61.94±3.98)μg/mL,(94.53± 1.68) μg/mL and(69.7±2.65)μg/mL for DPPH,HRSA,NO,FRAP,LPO and SOL) radical scavenging activities, ***:In conclusion,the hepatoprotective effect of the *** leaf extract might be due to the presence of phenolic groups,terpenoids and alkaloids and in vitro antioxidant properties.

关键词： Antioxidant ccl_4 Histopathology Mangroves Hepatoprotective activity Lumnitzera racemosa Histopathological Phenolic Alkaloid Antioxidant property Hepatoprotective Radical scavenging activity Phenolic Alkaloid

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姜黄素对草鱼急性肝损伤的保护作用研究

湖北农业科学 2016年第6期55卷 1514-1517页

作者：喻运珍余少梅熊文静张生元徐志强郑翠华周汝珍武汉市水产科学研究所武汉430207 中博水产生物技术有限公司武汉430207 华中农业大学水产学院武汉430070 黄冈市水产科学研究所湖北黄冈438000

以ccl_4诱导的草鱼(Ctenopharyngodon idellus)急性肝损伤模型为基础,考察姜黄素对肝脏组织的保护作用。对草鱼腹腔注射不同剂量ccl_4-橄榄油后,分别于不同时间点测定血清中谷丙转氨酶(GPT)、谷草转氨酶(GOT)活性,确定ccl_4-橄榄油最佳... 详细信息

以ccl_4诱导的草鱼(Ctenopharyngodon idellus)急性肝损伤模型为基础,考察姜黄素对肝脏组织的保护作用。对草鱼腹腔注射不同剂量ccl_4-橄榄油后,分别于不同时间点测定血清中谷丙转氨酶(GPT)、谷草转氨酶(GOT)活性,确定ccl_4-橄榄油最佳注射剂量和作用时间;以建立的草鱼急性肝损伤模型为基础,采用不同浓度姜黄素(5、25、75、150、300 mg/kg)进行灌胃给药,观察草鱼血清和肝脏组织中相关生化指标变化情况。结果表明,用15%的ccl_4-橄榄油腹腔注射(剂量为0.1 m L/10 g鱼体重)24 h后,使草鱼血清中GPT、GOT水平升高(Pccl_4诱导的草鱼肝组织损伤具有保护作用。

关键词：草鱼(Ctenopharyngodon idellus) ccl_4 姜黄素肝损伤

紫草素拮抗膜脂流动性下降和脂质过氧化损伤的作用

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中国公共卫生学报 1998年第6期17卷 330-332页

作者：陈炳卿周少波王桂杰孙长颢博力雁哈尔滨医科大学营养与食品卫生学教研室中国预防医学科学院营养与食品卫生学研究所佳木斯大学医学院生化教研室黑龙江省卫生防疫站

ＳＤ大鼠按体重随机分成５组，喂饲含脂肪酸组成不同的饲料９０天，研究其对肝中脂肪酸组成和膜脂流动性的影响及紫草素阻抑ＣＣｌ４诱导的肝细胞膜脂流动性下降和脂质过氧化损伤的能力。结果表明肝脏中的脂肪酸组成与摄入饲料的脂肪酸... 详细信息

ＳＤ大鼠按体重随机分成５组，喂饲含脂肪酸组成不同的饲料９０天，研究其对肝中脂肪酸组成和膜脂流动性的影响及紫草素阻抑ＣＣｌ４诱导的肝细胞膜脂流动性下降和脂质过氧化损伤的能力。结果表明肝脏中的脂肪酸组成与摄入饲料的脂肪酸组成呈显著的正相关（相关系数ｒ为０８５３）；不同脂肪酸组成的肝脏，其细胞膜脂流动性之间有显著差异（Ｐ＜００５），摄食含多不饱和脂肪酸（ＰＵＦＡ）较多且以含ｎ－３系列脂肪酸最多的第４组，其膜脂流动性较好，但当加入１００μｌＣＣｌ４时，各组的膜脂流动性均显著降低，且以第４组的降低最显著。而当加入１００μｌ００５ｇ／Ｌ紫草素时，则能不同程度地拮抗由于ＣＣｌ４引起的膜脂流动性的降低，在第４组其拮抗效果最好。加入前后有非常显著的差异。紫草素也可以显著拮抗由ＣＣ１４诱导的肝脏脂质过氧化损伤，拮抗的作用程度因使用的紫草素浓度及肝脏中含脂肪的饱和程度有很大差异。第４组肝脏含ＰＵＦＡ最多，也最易受到ＣＣｌ４的诱导，且随使用紫草素浓度增大，阻抑能力增加。

关键词：紫草素 ccl_4 膜流动性脂质过氧化脂肪酸肝脏

CCI_4致大鼠肝损伤早期血清TBA,α-GST,PNP,OCT的变化

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CCI_4致大鼠肝损伤早期血清TBA,α-GST,PNP,OCT的变化