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The new antioxidant 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2- dihydroquinoline has a protective effect against carbon tetrachloride-induced hepatic injury in rats

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The Journal of Biomedical Research 2022年第6期36卷 423-434页

作者： Evgenii Dmitrievich Kryl'skii Darya Andreevna Sinitsyna Tatyana Nikolaevna Popova Khidmet Safarovich Shikhaliev Svetlana Mikhajlovna Medvedeva Larisa Vladimirovna Matasova Valentina Olegovna Mittova Department of Medical Biochemistry and Microbiology Voronezh State UniversityVoronezhVoronezh region 394018Russia Department of Organic Chemistry Voronezh State UniversityVoronezhVoronezh region 394018Russia Department of Clinical Laboratory Diagnostics Voronezh State Medical University named after N.N.BurdenkoVoronezhVoronezh region 394036Russia

Liver diseases with the central pathogenetic mechanism of oxidative stress are one of the main causes of mortality ***,dihydroquinoline derivatives,which are precursors of hepatoprotectors and have antioxidant activity,are of *** have previously found that some compounds in this class have the ability to normalize redox homeostasis under experimental ***,we initially analyzed the hepatoprotective potential of the dihydroquinoline derivative 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline(BHDQ)for carbon tetrachloride(ccl4)-induced liver injury in *** suggested that BHDQ normalized the alanine aminotransferase,aspartate aminotransferase,and gamma-glutamyl transpeptidase in *** also observed an improvement in liver tissue morphology related to *** with ccl4-induced liver injuries treated with BHDQ had less oxidative stress compared to animals with ccl4-induced liver *** promoted activation changes in superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase,and glutathione transferase on control values in animals with ccl4-induced liver *** also activated gene transcription in Sod1 and Gpx1 via nuclear factor erythroid 2-related factor 2 and forkhead box protein O1 ***,the compound of concern has a hepatoprotective effect by inhibiting the development of necrotic processes in the liver tissue,through antioxidation.

关键词： ccl4-induced hepatic injury oxidative stress 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1 2-dihydroquinoline antioxidants

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