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Na2O对低碱度保护渣结晶性能的影响

河北冶金 2024年第6期 10-16+57页

作者：马坤霞王浩南郭银星王杏娟河钢集团唐钢公司华北理工大学冶金与能源学院

裂纹敏感性钢种所用连铸保护渣普遍通过提高碱度来增强结晶性能，但高碱度会使得铸坯与结晶器之间的润滑变差，增大铸坯表面产生缺陷的风险。设计低碱度保护渣，使其能够具有与高碱度保护渣同样的结晶性能，并同时保持良好的润滑性能，... 详细信息

裂纹敏感性钢种所用连铸保护渣普遍通过提高碱度来增强结晶性能，但高碱度会使得铸坯与结晶器之间的润滑变差，增大铸坯表面产生缺陷的风险。设计低碱度保护渣，使其能够具有与高碱度保护渣同样的结晶性能，并同时保持良好的润滑性能，是协调裂纹敏感性钢种连铸过程中保护渣润滑性与控制传热关系的一项有效措施。本文采用SHTT-Ⅱ单丝设备，对不同Na2O含量保护渣进行结晶性能测试，并绘制TTT和cct曲线；利用Scigress分子动力学软件进行模拟研究，发现随Na2O含量的增加，保护渣结晶温度升高，结晶率提升，孕育时间缩短，临界冷却速率逐渐增大，结晶出现变早，较易结晶。高温条件下熔渣结构体网络聚合度减小，黏度逐渐降低。在实验用Na2O含量范围内，当Na2O含量增加到15%时，在凝固过程中三配位氧个数增加150左右，有化合物生成。表明增加Na2O含量可以控制弯月面区域极冷条件下的传热，实现低温快速结晶。

关键词：保护渣 Na2O 低碱度结晶性能 TTT cct

TEG和cct相关参数对全膝关节置换术后下肢静脉血栓形成的预测价值

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中国实用乡村医生杂志 2024年第6期31卷 54-57页

作者：李兴晶王志震燕东展聊城市第二人民医院骨科临清市人民医院骨病科

目的探讨血栓弹力图(thromboelastography,TEG)和传统凝血试验(conventional coagulation test,cct)相关参数对全膝关节置换术后下肢静脉血栓形成的预测价值。方法选取2021年6月—2022年6月在聊城市第二人民医院进行全膝关节置换术的... 详细信息

目的探讨血栓弹力图(thromboelastography,TEG)和传统凝血试验(conventional coagulation test,cct)相关参数对全膝关节置换术后下肢静脉血栓形成的预测价值。方法选取2021年6月—2022年6月在聊城市第二人民医院进行全膝关节置换术的患者137例作为研究对象，将全膝关节置换术后发生静脉血栓的43例患者纳入静脉血栓组，将未发生静脉血栓的94例患者纳入非静脉血栓组。于术后的第3 d采用TEG和cct评价患者的凝血功能状态，比较两组患者的TEG和cct相关参数，采用ROC评估TEG和cct相关参数在全膝关节置换术后静脉血栓形成的诊断价值，并采用logistic回归分析全膝关节置换术后静脉血栓形成的影响因素。结果静脉血栓组和非静脉血栓组的α角、描记图最大振幅、凝血综合指数、活化部分凝血活酶时间、凝血酶原时间、D-二聚体比较，差异有统计学意义(Pcct相关参数诊断全膝关节置换术后下肢静脉血栓形成效能更佳。

关键词：静脉血栓下肢 TEG cct 全膝关节置换预测价值

Anticarin-β shows a promising antiosteosarcoma effect by specifically inhibiting cct4 to impair proteostasis

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2268-2279页

作者： Gan Wang Min Zhang Ping Meng Chengbo Long Xiaodong Luo Xingwei Yang Yunfei Wang Zhiye Zhang James Mwangi Peter Muiruri Kamau Zhi Daic Zunfu Ke Yi Zhang Wenlin Chen Xudong Zhao Fei Ge Qiumin Lv Mingqiang Rong Dongsheng Li Yang Jin Xia Sheng Ren Lai Key Laboratory of Animal Models and Human Disease Mechanisms Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesKunming Primate Research Centerand National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyKunming 650107China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Institutes for Drug Discovery and Development Chinese Academy of SciencesShanghai 201203China Sino-African Joint Research Center Chinese Academy of ScienceWuhan 430074China Department of Pathology First Afﬁliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Orthopaedic Surgery First Afﬁliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Breast Surgery Third Afﬁliated Hospital of Kunming Medical UniversityYunnan Cancer CenterKunming 650118China Department of Breast Surgery First Afﬁliated Hospital of Kunming Medical UniversityKunming 650032China Department of Biosciences University of OsloOslo 0316Norway Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental ProtectionAnd State Key Laboratory of Environmental HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 434000China Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan 430071China

Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. The chaperonin T-complex protein ring complex(TRiC) contains eight paralogous subunits(cct1-8), and assists the folding of as many as 10% of cytosolic proteome.TRiC is essential for the progression of some cancers, but the roles of TRiC subunits in osteosarcoma remain to be explored. Here, we show that cct4/TRiC is significantly correlated in human osteosarcoma,and plays a critical role in osteosarcoma cell survival. We identify a compound anticarin-β that can specifically bind to and inhibit cct4. Anticarin-β shows higher selectivity in cancer cells than in normal cells. Mechanistically, anticarin-β potently impedes cct4-mediated STAT3 maturation. Anticarin-β displays remarkable antitumor efficacy in orthotopic and patient-derived xenograft models of osteosarcoma.Collectively, our data uncover a key role of cct4 in osteosarcoma, and propose a promising treatment strategy for osteosarcoma by disrupting cct4 and proteostasis.

关键词： Proteostasis cct TRiC Osteosarcoma STAT3 Anticarin-β PDX model

cct and TTT Diagrams to Characterize Crystallization Behavior of Mold Fluxes

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Journal of Iron and Steel Research(International) 2008年第4期15卷 32-37页

作者： WEN Guang-hua LIU Hui TANG Ping College of Materials Science and Engineering Chongqing University Chongqing 400044 China

The isothermal and non-isothermal experiments were performed to construct the continuous cooling transformation （cct） and temperature time transformation （TTT） diagrams of four industrial mold fluxes through visual observations in an experimental apparatus based on the single hot thermocouple technique （SHTT）. The results of the cct diagrams indicate that ① the crystallization temperature of mold fluxes lowers as the cooling rate increases, ② the mold fluxes have larger critical cooling rate, higher crystallization temperature, and less onset time of crystallization when the basicity increases or the viscosity decreases, ③ the influences of the melting points of the mold fluxes on their crystallization tendency are not significant. Isothermal tests show that the onset time of crystallization decreases at first, and then increases, and finally represents a ＂C＂ shape with increasing isothermal temperature. The TTT diagrams of four industrial mold fluxes were divided into two separate ＂C＂ shape regions. The crystal phase of C20A selected was analyzed by X-ray diffraction, which is cuspidine （Ca4 Si2 O7F2 ） over I 100 ℃ and calcium silicon oxide fluoride （Ca2SiO2F2） below 1 100℃. When compared with the TTT diagram, the cct diagram can provide a more realistic estimate of the critical cooling rate of the mold fluxes. Thus, both the cct and TTT diagrams can unambiguously describe the crystallization phenomena of the mold fluxes.

关键词： mold flux cct TTT critical cooling rate crystallization

Effects of Nb on the microstructure and mechanical properties of 38MnB5 steel

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International Journal of Minerals,Metallurgy and Materials 2018年第10期25卷 1181-1190页

作者： Li Lin Bao-shun Li Guo-ming Zhu Yong-lin Kang Ren-dong Liu School of Material Science and Engineering University of Science and Technology BeijingBeijing 100083China Ansteel Technology Center Anshan 114009China

The effects of the microalloying element niobium(Nb) on the microstructure and mechanical properties of the hot stamped steel 38 Mn B5 were investigated. The impact of Nb addition on the microstructure was studied through scanning electron microscopy(SEM), transmission electron microscopy(TEM), and X-ray diffraction(XRD). The experimental results indicated that the microstructures of the steel containing Nb were finer than those of the steel without Nb. Moreover, Nb mainly presented as a second-phase particle in 38MnB5 steel, and the particles included Nb carbonitrides. In addition, the tensile strength and elongation of the hot rolled and hot stamped steels were also measured, and they demonstrated that the appropriate addition of Nb was beneficial to the mechanical properties of 38 MnB5. Under the same conditions, the tensile strength of 38 MnB5 Nb was higher than that of 38 MnB5, which increased from 2011 to 2179 MPa. The yield strength also increased from 1316 to 1476 MPa, and the elongation increased from 5.92% to 6.64%. Overall, Nb had a positive effect on the performance of the hot stamped steel.

关键词： hot stamping steel cct curve microstructure mechanical properties precipitation

cct family genes in cereal crops: A current overview

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The Crop Journal 2017年第6期5卷 449-458页

作者： Yipu Li Mingliang Xu National Maize Improvement Center of China China Agricultural University Beijing 100193 China

Control of flowering time is crucial for reproductive success of cereal crops, and has a significant impact on grain yield as well as adaptation to diverse environmental conditions.Plants integrate signals from both environmental cues and endogenous regulatory pathways to fine-tune flowering time. The cct domain originally described to a 43-amino acid sequence at the C-terminus of three Arabidopsis proteins, namely CONSTANS(CO),CO-LIKE, and TIMING OF CAB1(TOC1). The cct domain-containing genes(cct genes),which encode transcription co-factors, are the major genetic determinants that modulate flowering time, and this in turn enables plants to effectively expand their territory to take advantage of favorable habitats. Moreover, certain cct genes have pleiotropic effects on morphological traits and confer resistance/tolerance to biotic/abiotic stresses. cct genes can be classified into three families, namely COL(CONSTANS-like), PRR(Pseudo-response regulator), and CMF(cct motif family),based on their non-cct domains. During domestication, natural and artificial selection resulted in reduced nucleotide diversity of cct genes in modern cultivated cereals than their wild types. Here, we review the features and functions of cct genes in cereal crops and propose future research to focus on cct genes and their utilization in crop breeding.

关键词： cct domain Flowering time Photoperiod Pleiotropy

Optical simulation of phosphor layer of white LEDs

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Journal of Semiconductors 2013年第5期34卷 41-45页

作者：廖骏源饶海波王玮万贤龙周琳淞周炟王雪梅雷巧林 University of Electronic Science and Technology of China

A Matlab （2009a） program was developed to simulate the photons emitted by the LED chips. The photons＇ transmission, reflection, and refraction in phosphor layers with different shapes were calculated in this program. The cct was calculated at different emergent angles with different layer profiles, such as planar layer, hemispherical layer （with different diameters）, half ellipsoid layer and other irregular shapes. As a consequence of optimization of angular color uniformity, the trend of configuration of the phosphor layer was discussed and analyzed.

关键词： Monte Carlo method white LED cct YAG：Ce3＋ phosphor coating

Enhancement of luminescence intensity and spectroscopic analysis of Eu^(3+) activated and Li^+ charge-compensated Bi_2O_3 nanophosphors for solid-state lighting

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Journal of Rare Earths 2019年第4期37卷 356-364页

作者： S.Ashwini S.C.Prashantha RamachANDra Naik H.Nagabhushana Department of Physics Channabasaveshwara Institute of Technology Research Center Department of Science East West Institute of Technology Department of Physics New Horizon College of Engineering CNR Rao Center for Advanced Materials Tumkur University

The present work reports the synthesis, characterization, photoluminescence and photocatalytic activity of Eu^(3+)(1 mol%-11 mol%) doped and Li^+(0.5 mol%-5 mol%) co-doped Bi_2 O_3 nanophosphors(NPs) by sonochemical method. The average particle size was estimated using powder X-ray diffraction(PXRD)and transmission electron microscopy(TEM) and is found to be in the range of 30-35 nm. The scanning electron microscopy(SEM) images were highly dependent on sonication time and concentration of epigallocatechin gallate(EGCG) bio-surfactant. The energy gap of doped and co-doped Bi_2 O_3 nanophosphors was estimated using Kubelka-Munk(K-M) function and is found to be in the range of2.9-3.08 eV. The effect of Li+ co-doping on luminescence of optimized Bi_2 O_3:Eu^(3+) was studied and is found about more than 3 fold enhancement of emission intensity. Judd-Ofelt parameters(Ω_2, Ω_4 and Ω_6).transition probabilities(A_T), quantum efficiency(η), luminescence lifetime(τ_(rad)), color chromaticity coordinates(CIE) and correlated color temperature(cct) values were estimated from the emission spectra and are discussed in detail. The estimated CIE chromaticity co-ordinates are very close to the NTSC(National Television Standard Committee) standard value of red emission. The synthesized NPs show excellent photocatalytic activity of acid red-88 under UV-light irradiation, which can degrade 98.1% in60 min. The decreasing electron-hole pair recombination rate with quick electron transfer ability is predominantly ascribed to the balance between crystallite size, morphology, band gap, defects, surface area, etc. These results show a light for the use of sonochemical route of Bi_2 O_3:Eu^(3+):Li^+ in solid state display and photocatalytic applications.

关键词： Bi2O3:Eu3+:Li+ Sonochemical Photoluminescence CIE n cct Photocatalysis Rare earths

Effect of Rare Earth Elements on Transformation Behavior and Microstructure Characteristics in X80 Pipeline Steel

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稀有金属材料与工程 2011年第S3期40卷 51-55页

作者： Liu Chengjun, Liu Hongliang, Jiang Maofa Northeastern University, Shengyang 110004, China Northeastern Univ Sch Met & Mat Shenyang 110004 Peoples R China

The studies of the rare earth elements (RE) in low carbon steels suggest that the RE inhibits the ferrite transformation, which is the same effect as Mo alloying in pipeline steels. The purpose of this work is to discuss the relationships between the RE microalloying and the microstructure in pipeline steels. The X80 pipeline steels with different RE and Mo additions have been produced by vacuum induction furnace. The Gleeble-2000 thermal simulator, optical microscopy, and scanning electron microscopy with EBSD have been used. The continuous cooling transformation (cct) curve was obtained and analyzed, combined with the study of microstructure. The results indicate that the microstructure of thermal simulator test metal is characteristic of quasi-polygonal ferrite and bainite, and trace RE could significantly inhibit the transformation of quasi-polygonal ferrite. The 0.0040wt% content of RE plays the same role as 0.1 wt% content of Mo alloying in pipeline steels. What’s more, the fine bainite grained structure is obtained with RE microalloying. Theoretically RE could be employed in pipeline steels as microalloying, and a partial substitution of Mo by RE is possible.

关键词： rare earth elements pipeline steel transformation microstructure cct