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第十四届全国免疫学学术大会

作者： Cai Zhang Yanyan Da Yuxia Liu Yuan Hu Nan Lu Institute of Immunopharmacology and Immunotherapy School of Pharmaceutical SciencesShandong University 山东大学临床医学院

Activation of the stimulator of interferon gene(STING)-controlled innate pathway within the tumor microenvironment is a promising therapeutic strategy in many cancers.H owever,the effect of STING agonist on natural killer(nk) cell-mediated anti-tumor responses in pancreatic carcinoma remains ***,we evaluated the impact of a classical STING agonist cyclic GMP-AMP(cGAMP) on nk cells in pancreatic *** found it could directly activate nk cells and enhance the killing sensitivity of pancreatic cells to nk cells *** indicated that cGAMP had the potential for use as a next-generation adjuvant for nk cells ***,combined with mesothelin-targeting car-nk-92 cells and cGAMP displayed greater antitumor efficacy by inhibiting tumor growth and prolonging the survival time in mice models of pancreatic *** results demonstrated that the combination of STING agonist and nk cells had potential applications in pancreatic carcinoma and might provide new ideas and basis for clinical immunotherapy of pancreatic carcinoma.

关键词： STING STING agonist cGAMP,Pancreatic carcinoma car-nk cells

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Manufacturing car-nk against tumors: Who is the ideal supplier?

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Chinese Journal of Cancer Research 2024年第1期36卷 1-16页

作者： Feifei Guo Yi Zhang Jiuwei Cui The First Hospital of Jilin University Cancer CenterChangchun 133021China

Chimeric antigen receptor-natural killer(car-nk) cells have emerged as another prominent player in the realm of tumor immunotherapy following car-T cells. The unique features of car-nk cells make it possible to compensate for deficiencies in car-T therapy, such as the complexity of the manufacturing process, clinical adverse events, and solid tumor challenges. To date, car-nk products from different allogeneic sources have exhibited remarkable anti-tumor effects on preclinical studies and have gradually been applied in clinical ***, each source has advantages and disadvantages. Selecting a suitable source may help maximize car-nk cell efficacy and increase the feasibility of clinical transformation. Therefore, this review discusses the development and challenges of car-nk cells from different sources to provide a reference for future exploration.

关键词： car-nk cells cord blood iPSC nk-92 cells peripheral blood

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Engineered human pluripotent stem cell-derived natural killer cells: the next frontier for cancer immunotherapy

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Blood Science 2019年第1期1卷 4-11页

作者： Huang Zhu Dan S.Kaufman Division of Regenerative Medicine Department of MedicineUniversity of California San DiegoSan DiegoCAUSA

Adoptive immunotherapy using immune effector cells has revolutionized cancer treatments with approval of two autologous chimeric antigen receptor(car)T cell therapies by the US *** trials using natural killer(nk)cell-based adoptive immunotherapy have been shown to be safe and effective for treatment of multiple malignancies,especially acute myelogenous ***,most of these trails use primary nk cells isolated from peripheral or cord blood which can have donor-dependent variability and can be challenging to genetic engineer to improve antitumor functions,limiting the widespread use of this promising new *** cells can now be routinely produced from human pluripotent stem cells,both human embryonic stem cells(hESCs)and induced pluripotent stem cells(iPSCs).These pluripotent stem cells are homogenous,easy to genetically modify on a clonal level and can be used as unlimited source of nk cells,making them ideal population to develop standardized,off-the-shelf adoptive nk cell therapy *** this review,we discuss recent advances of obtaining and expanding hESC and iPSC-derived nk cells and novel genetic engineering strategies that are being applied to improve their antitumor functions.

关键词： Adoptive nk cell therapy Cancer immunotherapy car-nk cells Chimeric antigen receptor Human stem cells Natural killer cells

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