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阴道闭锁(Ⅰ型)、处女膜闭锁伴ca125、ca19-9异常增高1例

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中国计划生育和妇产科 2025年第02期 12-15页

作者：孙杭尹娜高宏平郑娇张玉马珂珂徐州医科大学附属徐州市立医院肛肠科

1病例资料患者女，12岁，未婚未育，因“周期性下腹胀痛6月，加重6天”，于2022-10-06收入徐州医科大学附属徐州市立医院妇科。患者6月前开始出现下腹胀痛不适，疼痛轻微，持续4～5天后疼痛逐渐消失，无其他不适，近6月来每月出现类似... 详细信息

1病例资料患者女，12岁，未婚未育，因“周期性下腹胀痛6月，加重6天”，于2022-10-06收入徐州医科大学附属徐州市立医院妇科。患者6月前开始出现下腹胀痛不适，疼痛轻微，持续4～5天后疼痛逐渐消失，无其他不适，近6月来每月出现类似情况，6天前再次开始出现下腹胀痛，疼痛较前明显，逐渐加重，自行口服止痛片后好转，遂至淮北市人民医院就诊，

关键词：阴道闭锁处女膜闭锁 ca125 ca19-9

ca19-9 level determines therapeutic modality in pancreatic cancer patients with para-aortic lymph node metastasis

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 75-80页

作者： Tadafumi Asaoka Atsushi Miyamoto Sakae Maeda Naoki Hama Masanori Tsujie Masataka Ikeda Mitsugu Sekimoto Shoji Nakamori Department of Surgery National Hospital Organization Osaka National Hospital

Background: In general, para-aortic lymph node(LN16) metastasis has been considered as a contraindication for pancreatic resection. However, some pancreatic cancer patients with LN16 metastasis have been reported to survive for longer than expected after pancreatectomy. The purpose of this study was to determine whether pancreatic cancer patients with LN16 metastasis might benefit from ***: We retrospectively reviewed 201 consecutive patients with invasive pancreatic ductal adenocarcinoma who underwent surgery at Osaka National Hospital between April 2003 and December *** patients included 22 patients with LN16 metastasis who underwent an extended lymphadenectomy and 25 patients who underwent a palliative surgical biliary and gastric bypass. The clinicopathological data and outcomes were evaluated using univariate and multivariate ***: The overall survival of the patients with LN16 metastasis was poorer than that of the LN16-negative patients(P = 0.0014). An overall survival analysis of the LN16-positive patients stratified according to the preoperative ca19-9 level showed a significant difference between patients with a low preoperative ca19-9 level(≤360 U/mL) and those with a high preoperative ca19-9 level(>360 U/mL)(P = 0.0301). No significant difference in overall survival of patients was observed between those with LN16 positivity and those who underwent bypass surgery. However, the overall survival of the LN16-positive patients with a ca19-9 level ≤360 U/mL(n = 11) was significantly higher than that of those who underwent bypass surgery(P = 0.0452).Conclusion: Surgical resection and extended lymphadenectomy remains an option for pancreatic cancer patients with LN16-positivity whose ca19-9 level is ≤360 U/mL.

关键词： Pancreatic cancer ca19-9 Para-aortic lymph node

ca19-9时间分辨荧光免疫层析检测方法的建立

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生物工程学报 2018年第6期34卷 1012-1018页

作者：王云龙米亚双李玉林王继创程蕾闫生辉邓黎黎河南师范大学生命科学学院河南新乡453002 河南省生物工程技术研究中心河南郑州450121 生物标志物定量检测河南省工程实验室河南郑州450121 郑州职业技术学院河南郑州450121

本研究旨在建立一种定量检测血清中ca19-9含量的时间分辨荧光免疫层析检测方法。采用双抗体夹心法与荧光免疫层析技术,以羧基荧光微球和NC膜为载体将ca19-9配对抗体进行标记和包被,制备ca19-9检测试纸条。通过标记、包被抗体量对工艺进... 详细信息

本研究旨在建立一种定量检测血清中ca19-9含量的时间分辨荧光免疫层析检测方法。采用双抗体夹心法与荧光免疫层析技术,以羧基荧光微球和NC膜为载体将ca19-9配对抗体进行标记和包被,制备ca19-9检测试纸条。通过标记、包被抗体量对工艺进行优化,并通过线性范围、最低检出限、精密性等性能指标对ca19-9时间分辨荧光层析检测方法进行评价。最终确定20μL荧光微球的标记抗体量为80μg,检测线包被抗体浓度为1.5 mg/mL时,检测时间为15 min,线性范围为12.5–800 U/mL,最低检出限为6.32 U/mL,批内精密性与批间精密性均小于15%,平均回收率为101%,与罗氏电化学发光检测试剂盒平行检测50份临床样本,两者相关系数为0.980 6。初步建立了定量检测血清中ca19-9的荧光免疫层析检测方法,有较好的临床应用前景。

关键词： ca19-9 荧光免疫层析定量检测快检

Serum level of TSGF,ca242 and ca19-9 in pancreatic cancer

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World Journal of Gastroenterology 2004年第11期10卷 1675-1677页

作者： Jing-TingJiang Chang-PingWu Hai-FengDeng Minq-YanqLu JunWu Hong-YuZhang Wen-HuiSun MeiJi DepartmentofTumorBiologicalTreatment theThirdAffiliatedHospitalofSuzhouUniversityChangzhou213003JiangsuProvinceChina

AIM: To establish a method to detect the expression of the tumor specific growth factor TSGF, ca242 and ca19-9 in serum and evaluate their value in diagnosis of pancreatic cancer. METHODS: ELISA and Biochemical colorimetric assay were used to detect the serum content of TSGF, ca242 and ca19-9 in 200 normal cases, 52 pancreatitis patients and 96 pancreatic cancer patients. RESULTS: The positive likelihood ratios of TSGF, ca242 and ca19-9 were 5.4, 12.6 and 6.3, respectively, and their negative likelihood ratios were 0.10, 0.19 and 0.17, respectively. With single tumor marker diagnosed pancreatic cancer, the highest sensitivity and specificity of TSGF were 91.6% and 93.5%. In combined test with 3 markers, when all of them were positive, the sensitivity changed to 77.0% and the specificity and the positive predictive value were 100%. The levels of TSGF and ca242 were significantly higher in the patients with pancreatic cancer of head than those in the patients with pancreatic cancer of body, tail and whole pancreas, but the expression of ca19-9 had no correlation with the positions of the pancreatic cancer. The sensitivity of TSGF, ca242 and ca19-9 was increased with the progress in stages of pancreatic cancer. In stage I, the sensitivity of TSGF was markedly higher than ca242 and ca19-9. CONCLUSION: The combined use of TSGF, ca242 and ca19-9 expressions can elevate the specificity for pancreatmc cancer diagnosis. And it shows that it plays an important role to differentiate positions and tissue typing. It is a forepart diagnosis for the pancreatic cancer by combination checking. There is very important correlation between the three markers and the pancreatic cancer.

关键词： TSGF ca242 ca19-9 胰腺癌免疫血清肿瘤临床检验

Adjusting ca19-9 values to predict malignancy in obstructive jaundice:Influence of bilirubin and C-reactive protein

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World Journal of Gastroenterology 2012年第31期18卷 4150-4155页

作者： Gaetano La Greca Maria Sofia Rosario Lombardo Saverio Latteri Agostino Ricotta Stefano Puleo Domenico Russello Department of Surgical Sciences Organ Transplantation and Advanced TechnologiesUniversity of Catania95125 CataniaItaly

AIM:To find a possible relationship between inflammation and ca19-9 tumor marker by analyzing data from patients with benign jaundice(BJ) and malignant jaundice(MJ).METHODS:All patients admitted for obstructive jaundice,in the period 2005-2009,were prospectively enrolled in the study,obtaining a total of 102 *** admission,all patients underwent complete standard blood test examinations including C-reactive protein(CRP),bilirubin,*** were considered eligible for the study when they presented obstructive jaundice confirmed by instrumental examinations and increased serum bilirubin levels(total bilirubin > 2.0 mg/dL).The standard cut-off level for ca19-9 was 32 U/mL,whereas for CRP this was 1.5 mg/*** ca19-9 level was adjusted by dividing it by the value of serum bilirubin or by the CRP *** patients were divided into 2 groups,MJ and BJ,and after the adjustment a comparison between the 2 groups of patients was ***,specificity and positive predictive values were calculated before and after the ***:Of the 102 patients,51 were affected by BJ and 51 by *** ca19-9 levels were found in 71.7% of the *** the group of 51 BJ patients there were 29(56.9%) males and 22(43.1%) females with a median age of 66 years(range 24-96 years),whereas in the MJ group there were 24(47%) males and 27(53%) females,with a mean age of 70 years(range 30-92 years).Pathologic ca19-9 serum level was found in 82.3% of *** levels were pathologic in 66.6% of the patients with BJ and in 49% with *** and ca19-9 average levels were significantly higher in MJ compared with BJ(P = 0.000 and P = 0.02),while the CRP level was significantly higher in BJ(P = 0.000).Considering a ca19-9 cut-off level of 32 U/mL,82.3% in the MJ group and 54.9% in the BJ group were positive for ca19-9(P = 0.002).A ca19-9 cut-off of 100 U/mL increases the difference between the two groups:35.3% in BJ and 68.6% in MJ(P = 0.0007).Adjusting the ca1

关键词： Tumor marker ca19-9 C-reactive protein Bilirubin Pancreato-biliary malignancy Biliary stones

ca19-9对肝细胞癌和胆管细胞癌的诊断价值

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中华肝脏病杂志 2006年第4期14卷 299-300页

作者：陈漪王志明任正刚乐凡张博恒夏景林叶胜龙汤钊猷复旦大学附属中山医院肝内科复旦大学肝癌研究所上海200032

甲胎蛋白是诊断原发性肝癌的传统肝癌标志物,但约有30%～40%的原发性肝癌甲胎蛋白阴性.因而其他的肝癌标志物,如ca19-9等也应用于原发性肝癌的诊断.本研究旨在探讨ca19-9在原发性肝癌诊断中的临床意义.

关键词：癌,肝细胞癌,胆管细胞诊断 ca19-9

The prognostic value of preoperative serum levels of CEA,ca19-9 and ca72-4 in patients with colorectal cancer

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World Journal of Gastroenterology 2001年第3期7卷 431-434页

作者： Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published. Department of General Surgery First Affiliated Hospital Sun Yat-Sen University of Medical Sciences 58 Zhongshan 2nd Road Guangzhou 510080 Guangdong Province China. zcxzd@***

INTRODUCTIONcarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].carbohydrate antigen 19-9(ca19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6].

关键词： tumor markers/biological colorectal neoplasms/surgery colorectal neoplasms/blood carcinoembryonic antigen/serum ca19-9 antigen/ serum antigens, tumor-associated.carbohydrate/serum prognosis

Utility of serum ca19-9 in diagnosis of cholangiocarcinoma:In comparison with CEA

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World Journal of Gastroenterology 2004年第3期10卷 427-432页

作者： Xing-LeiQin Zuo-RenWang Jing-SenShi MinLu LinWang Quan-RuHe DepartmentofHepatobiliarySurgery FirstHospitalofXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina LuoyangCentralHospital Luoyang471009HenanProvinceChina DepartmentofHepatobiliarySurgery FirstHospitalofXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina

AIM:The diagnosis of cholangiocarcinoma is often difficult,making management approaches problematic. A reliable serum marker for cholangiocarcinoma would be a useful diagnostic test. The aims of our study were to evaluate the usefulness of a serum ca19-9 determination in the diagnosis of ***: We prospectively measured serum ca19-9 and CEA concentrations in patients with cholangiocarcinoma (n=35), benign biliary diseases (n=92), and healthy individuals (n=15). Serum ca19-9 and CEA concentrations were measured by an immunoradiometric assay without knowledge of the clinical ***:The sensitivity of a ca19-9 value>37KU·L^-1 and a CEA value >22μg·L^-1 in diagnosing cholangiocarcinoma were 77.14% and 68.57%, respectively. When compared with the benign biliary diseases group,the true negative rates of serum ca19-9 and CEA were 84.78% and 81.52%,respectively. The false positive rates of serum ca19-9 and CEA were 15.22% and 18.48%, whereas the accuracy of serum ca19-9 and CEA were 82.68% and 77.95%,respectively. Serum ca19-9 and CEA concentrations were significantly elevated (Pcarcinoma (290.31±5.34KU·L^-1 and 36.46±18.03μg·L^-1) compared with patients with benign biliary diseases (13.38±2.59KU·L^-1 and 13.84±3.85μg·L^-1) and healthy individuals (12.78±3.69KU·L^-1 and 11.48±3.37μg·L^-1). In 15 patients undergoing curative resection of cholangiocarcinoma,the mean serum ca19-9 concentration was decreased from a preoperative level of 286.41±4.36KU·L^-1 to a postoperative level of 62.01±17.43KU·L^-1 (P9.41±24.35μg·L^-1 to 28.69±11.03μg·L6-1(Pcarcinoma,however, no correlation was found between serum CEA and ca19-9 concentrations (r=-0.036).CONCLUSION:These data suggest that the serum ca19-9 determination is a useful addition to the available tests for the differential diagnosis of cholangiocarcinoma. Serum ca19-9 is

关键词：胆管上皮癌 ca19-9 血清学检查肿瘤标志物早期诊断 CEA

Single-cell RNA sequencing reveals the process of ca19-9 production and dynamics of the immune microenvironment between ca19-9 (+) and ca19-9 (−) PDAC

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Chinese Medical Journal 2024年第20期137卷 2415-2428页

作者： Deyu Zhang Fang Cui Kailian Zheng Wanshun Li Yue Liu Chang Wu Lisi Peng Zhenghui Yang Qianqian Chen Chuanchao Xia Shiyu Li Zhendong Jin Xiaojiang Xu Gang Jin Zhaoshen Li Haojie Huang Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Pancreatic Surgery Changhai HospitalNaval Medical UniversityShanghai 200433China College of Life Science Fujian Agriculture and Forestry UniversityFuzhouFujian 350000China Department of Pathology and Laboratory Medicine Tulane UniversityNew OrleansLA 70115 USA School of Medicine Tulane UniversityNew OrleansLA 70115 USA.

Background:Pancreatic ductal adenocarcinoma(PDAC)is one of the main types of malignant tumor of the digestive system,and patient prognosis is affected by difficulties in early diagnosis,poor treatment response,and a high postoperative recurrence *** antigen 19-9(ca19-9)has been widely used as a biomarker for the diagnosis and postoperative follow-up of PDAC ***,the production mechanism and potential role of ca19-9 in PDAC progression have not yet been ***:We performed single-cell RNA sequencing on six samples pathologically diagnosed as PDAC(three ca19-9-positive and three ca19-9-negative PDAC samples)and two paracarcinoma *** also downloaded and integrated PDAC samples(each from three ca19-9-positive and ca19-9-negative patients)from an online *** dynamics of the proportion and potential function of each cell type were verified through ***,we built an in vitro coculture cellular model to confirm the potential function of ***:Three subtypes of cancer cells with a high ability to produce ca19-9 were identified by the markers TOP2A,AQP5,and ***19-9 production bypass was discovered on antigen-presenting cancer-associated fibroblasts(apcaFs).Importantly,the proportion of immature ficolin-1 positive(FCN1+)macrophages was high in the ca19-9-negative group,and the proportion of mature M2-like macrophages was high in the ca19-9-positive *** proportions of these two macrophage subtypes were associated with an unfavourable clinical *** experiments indicated that ca19-9 could facilitate the transformation of M0 macrophages into M2 macrophages in the tumor ***:Our study described ca19-9 production at single-cell resolution and the dynamics of the immune atlas in ca19-9-positive and ca19-9-negative ***19-9 could promote M2 polarization of macrophage in the pancreatic tumor microenvironment.

关键词： carbohydrate antigen 19-9 ca19-9 Pancreatic ductal adenocarcinoma Single-cell RNA sequencing M2 macrophages Antigen-presenting cancer-associated fibroblast