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Unique immunological profile in patients with cOvid-19

cellular & Molecular Immunology 2021年第3期18卷 604-612页

作者： Stefania Varchetta Dalila Mele Barbara Olivier Stefania Mantovani Serena Ludovisi Antonella cerino Raffaele Bruno Alberto castelli Mario Mosconi Marco Vecchia Silvia Roda Michele Sachs catherine Klersy Mario U.Mondelli Division of Infectious Diseases Ⅱ and Immunology Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Internal Medicine and Therapeutics University of PaviaPaviaItaly Division of Infectious Diseases I Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of clinical SurgicalDiagnosticand Pediatric SciencesUniversity of PaviaPaviaItaly Division of Orthopaedics and Traumatology Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of clinical-Surgical Diagnostic and Pediatric SciencesUniversity of PaviaPaviaItaly clinical Epidemiology&Biometry Unit IRCCS Fondazione Polidinico San MatteoPaviaItaly

The relationship between severe acute respiratory syndrome coronavirus-2(SARS-coV-2)and host immunity is poorly *** performed an extensive analysis of immune responses in 32 patients with severe cOvid-19,some of whom succumbed A control population of healthy subjects was *** with cOvid-19 had an altered distribution of peripheral blood lymphocytes,with an increased proportion of mature natural killer(NK)cells and low T-cell *** cells and cD8^(+)T cells overexpressed T-cellimmunoglobulin and mucin domain-3(TIM-3)and *** cell exhaustion was attested by increased frequencies of programmed cell death protein 1(PD-1)positive cells and reduced frequencies of natural killer group 2 member D(NKG2D)-,DNAX accessory molecule-1(DNAM-1)-and sialic acid-binding Ig-like lectin 7(Siglec-7)-expressing NK cells,associated with a reduced ability to secrete interferon(IFN)γ.Patients with poor outcome showed a contraction of immature cD56^(bright) and an expansion of mature cD57^(+)F_(cEI)Rlγ^(eng) adaptive NK cells compared to *** serum levels of IL-6 were also more frequently identified in deceased patients compared to *** note,monocytes secreted abundant quantities of IL-6,IL-8,and IL-1β which persisted at lower levels several weeks after recovery with concomitant normalization of cD69,PD-1 and TIM-3 expression and restoration of cD8^(+)T cell numbers.A hyperactivated/exhausted immune response dominate in severe SARS-coV-2 infection,probably driven by an uncontrolled secretion of inflammatory cytokines by *** findings unveil a unique immunological profile in cOvid-19 patients that will help to design effective stage-specific treatments for this potentially deadly disease.

关键词： c0vid-19 NK cells TIM-3 IL6 Monocytes

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