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The Lapinized chinese strain vaccine Against classical Swine Fever Virus:A Retrospective Review Spanning Half A century

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Agricultural Sciences in china 2006年第1期5卷 1-14页

作者： QIU Hua-ji SHEN Rong-xian TONG Guang-zhi National Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001 P.R.China

classical swine fever （cSF）, a list A disease of Office International des Epizooties, is caused by classical swine fever virus （cSFV） belonging to the Flaviviridae family. The well-known lapinized chinese strain of cSFV, also known as c-strain, was developed in china in the mid-1950s. In the past half a century, the vaccine has been proved to be safe and immunogenic in pigs of essentially any age. It is of high efficacy, providing immunized animals with broad-spectrum, sometimes lifelong, protection, which is contributed by both cell-mediated immunity and humoral immunity, against essentially all genotypes or subgenotypes of the virus. The maternal antibodies derived from immunized sows can confer solid protection of their offspring from disease; however, they have been proved to inhibit the successful active immunization of c-strain vaccine. The complete genomes of c-strain and dozens of established or field strains have been sequenced and annotated. Recently, the reverse genetics system of c-strain has been developed, resulting in several c- strain-derived candidate marker vaccines. Many countries manage to control or even eradicate cSF with the aid of mass vaccination with c-strain. in spite of these efforts, the eradication of the disease worldwide remains a big challenge and needs to go a long way, and provably still resorts to genetically modified c-strain vaccine. The authors present an overview of the characteristics of the vaccine, which has stood the test of half a century.

关键词： classical swine fever classical swine fever virus c-strain vaccine

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