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Role of IL-6 in the contraceptive mechanism of intrauterine device

白求恩医科大学学报 2000年第6期26卷 597-599页

作者： Zhu Dan Wang Liyan Fu Li Jia Ruiying Dept.of Obsterics The Third Clinical CollegeBethune University of Medical SciencesChangchun 130031 central laboratory The Third Clinical CollegeNBUMS

目的 :探讨血清中白细胞介素 - 6(IL- 6)水平与宫内节育器 (IUD)存在的关系。方法 :采用酶联免疫吸附试验测定 64例置器妇女 (试验组 ,试验组又分为置器出血组和无出血组 ) ,以及60例健康妇女 (对照组 )血清中 IL- 6水平 ,同时测定两组... 详细信息

目的 :探讨血清中白细胞介素 - 6(IL- 6)水平与宫内节育器 (IUD)存在的关系。方法 :采用酶联免疫吸附试验测定 64例置器妇女 (试验组 ,试验组又分为置器出血组和无出血组 ) ,以及60例健康妇女 (对照组 )血清中 IL- 6水平 ,同时测定两组血清中 c-反应蛋白 (cRP)水平。结果 :试验组 64例中有 31例血中 IL- 6水平升高 ,与对照组相比差异显著 (P0 .0 5)。试验组及对照组血清中 cRP检验结果均为阴性。结论 :宫内节育器引起子宫内膜无菌性炎症反应 ,导致部分妇女血清中 IL- 6水平升高。IL-

关键词： intrauterine contraceptive devices interleukin-6 c-reactive protein

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Inflammatory markers and elderly patients with stroke

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Journal of Geriatric cardiology 2004年第1期1卷 13-页

作者： Mark A.Simaga Neurology consultant Northern Indiana Neurological InstituteMerrillville INUSA

c-reactive protein (cRP) is associated with unfavorable outcome in patients with acute ischemic syndromes and in patients with chronic stable *** cRP levels suggestive of heightened inflammatory state in vascular conditions are often associated with elevated interleukin-6 (IL-6) *** aim of our study was to show the predictive importance of cRP and IL-6 levels in patients with ischemic stroke that has not been fully *** We studied 647 consecutive elderly patients (>65 years) with stroke who were documented with ischemic stroke,presence of significant carotid atherosderosis and absence of atrial *** study population included 150 patients (74 men,76 women,mean age 74±2).Patients underwent evaluation of high sensitive cRP and IL-6 levels at baseline,during hospitalization and at *** In-hospital mortality was 6%,1 year mertality was 15% and a second cerebrovascular event occurred in 12% of *** with in- hospital events had significantly higher baseline cRP and IL-6 levels than patients without events (3.8+1.1 vs 1.9±0.9 mg/L,Pctively).Also cRP and IL-6 levels were significantly higher in those patients with an event within 3 months of discharge compared to patients without an event (3.6±1.3 vs 1.1±0.7 mg/L,Pctively).Both base line cRP levels and IL-6 were predictive of events both in-hospital and after 3 months while cRP and IL-6 levels at baseline were not associated with a poor 1 year *** cRP levels were associated with an unfavorable outcome only when IL-6 levels were also *** a stepwise multivariate analysis IL-6 level was a stronger predictor of outcome than *** In conclusion,elevated cRP and IL-6 levels may identify elderly patients at increased medium term risk,but do not predict one year events in this subset of *** levels predict events only when they are

关键词： c-reactive protein interleukin-6 inflammatory markers stroke

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Study on diagnosis parameters of endometritis in dairy cows

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畜牧与饲料科学 2015年第Z1期 351-351页

作者： WANG Mengling LIU Mingchao ZHU Yaohong Department of Veterinary clinical Sciences College of Veterinary MedicineChina Agricultural University

Endometritis in dairy cow herds is a serious economic problem all over the world due to the large economic *** endometritis is an important postpartum disease in dairy cows,but conventional cytobrush diagnosis often gives imprecise *** inflammatory cytokine levels in serum from dairy cows with clinical or subclinical endometritis during the voluntary waiting period may provide valuable information that can serve as a diagnostic tool for the uterine *** objective of this study was to analysis diseaseassociated changes of inflammatory cytokines in serum as potential diagnostic *** study was performed on 28 cows on day 30 after *** on the results of cytological tests,the cows were divided into three groups:clinical endometritis(10 cows);subclinical endometritis(6 cows);healthy control(12 cows).clinical endometritis was diagnosed by observation of vaginal discharges(> 50%pus) and subclinical endometritis was diagnosed by evaluation of uterine flush cytology(neutrophils > 5.5%) at 4 weeks *** samples were obtained from 28 cows at 4 and 25 weeks postpartum for evaluation of tumor necrosis factor-α(TNF-α) and creactive protein(cRP) *** of cRP were greater(Pcows with clinical endometritis than in cows with subclinical endometritis and healthy controls,whereas concentrations of TNF-α in both cows with clinical and subclinical endometritis were greater(Pconclusion,cows with endometritis have greater inflammatory cytokine concentrations in serum than healthy cows,concentrations of TNF-α and cRP differences were *** endometritis of dairy cows is reflected by concentrations of TNF-α in *** data emphasize the role of TNF-α and cRP for bovine subclinical endometritis,and point the way for analysis of TNF-α as potential candidate parameter associated with subclinical endometritis.

关键词： dairy cows endometritis tumor necrosis factor-α c-reactive protein

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Transitioning antimicrobials from intravenous to oral in pediatric acute uncomplicated osteomyelitis

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World Journal of clinical Pediatrics 2016年第3期5卷 244-250页

作者： Nathan Batchelder Tsz-Yin So Department of Pharmacy Moses H.Cone Memorial Hospital

Osteomyelitis is a bone infection that requires prolonged antibiotic treatment and potential surgical *** left untreated,acute osteomyelitis can lead to chronic osteomyelitis and overwhelming *** treatment is necessary to prevent complications,and the standard of care is progressing to a shorter duration of intravenous(Ⅳ) antibiotics and transitioning to oral therapy for the rest of the treatment *** systematically reviewed the current literature on pediatric patients with acute osteomyelitis to determine when and how to transition to oral antibiotics from a short Ⅳ *** have shown that switching to oral after a short course(i.e.,3-7 d) of Ⅳ therapy has similar cure rates to continuing long-term Ⅳ *** Ⅳ use is also associated with increased risk of *** that help guide clinicians on making the switch include a downward trend in fever,improvement in local tenderness,and a normalization in c-reactive protein *** on the available literature,we recommend transitioning antibiotics to oral after 3-7 d of Ⅳ therapy for pediatric patients(except neonates) with acute uncomplicated osteomyelitis if there are signs of clinical improvement,and such regimen should be continued for a total antibiotic duration of four to six weeks.

关键词： Antimicrobials c-reactive protein Intravenous Oral Osteomyelitis Pediatrics

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