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combined Effects of Family History of cardiovascular Disease and Serum c-reactive protein Level on the Risk of Stroke: A 9.2-year Prospective Study among Mongolians in china

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Biomedical and Environmental Sciences 2017年第9期30卷 632-640页

作者： ZHU Zheng Bao HUANGFU Xin Feng ZHONG chong Ke ZHOU Yi Peng TIAN Yun Fan BUREN Batu XU Tian WANG Ai Li LI Hong Mei ZHANG Ming Zhi ZHANG Yong Hong Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Medical College of Soochow University Department of Epidemiology Tongliao Center for Disease Prevention and Control Department of Neurology Affiliated Hospital of Nantong University

Objective We aimed to evaluate the combined effect of a family history of cardiovascular disease（cVD） and high serum c‐reactive protein（cRP） on the stroke incidence in an Inner Mongolian population in china. Methods A prospective cohort study was conducted from June 2002 to July 2012, with 2,544 participants aged 20 years and over from Inner Mongolia, china. We categorized participants into four groups based on the family history of cVD and cRP levels. Results We adjusted for age; sex; smoking; drinking; hypertension; body mass index; waist circumference; and blood glucose, triglycerides, low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol levels. compared with the group with no family history of cVD/low cRP levels, the group with family history of cVD/high cRP levels had a hazard ratio（HR） of 1.78 [95% confidence interval（cI）, 1.03‐3.07; P = 0.039] of stroke, and an HR of 2.14（95% cI, 1.09‐4.20; P = 0.027） of ischemic stroke. The HRs of hemorrhagic stroke for the other three groups were not statistically significant（all P 〉 0.05）. conclusion Participants with both a family history of cVD and high cRP levels had the highest stroke incidence, suggesting that high cRP levels may increase stroke risk, especially of ischemic stroke, among individuals with a family history of cVD.

关键词： Family history of cardiovascular disease c‐reactive protein Stroke Prospective study

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