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byrsocarpus coccineus Schumach.&Thonn.(Connaraceae)叶子提取物的降血糖和抗氧化活性(英文)

中国天然药物 2013年第6期11卷 628-637页

作者： Oluwakemi K.Dada Abidemi J.Akindele Olufemi A.Morakinyo Margaret O.Sofidiya Duncan Ota Department of Pharmacology Faculty of Basic Medical SciencesCollege of MedicineUniversity of Lagos Department of Physiology Faculty of Basic Medical SciencesCollege of MedicineUniversity of Lagos Department of Pharmacognosy Faculty of PharmacyUniversity of Lagos

AIM: Diabetes Mellitus is associated with significant morbidity and mortality worldwide. The need for enhanced efficacy and safety, and cheaper and more readily available new drugs has increased the search for new antidiabetic drugs from plants. This study was conducted to investigate the antidiabetic activity of the hydroethanolic leaf extract of B. coccineus in rats. METHODS: The effect of B. coccineus extract(100–800 mg·kg–1, p.o.) on blood glucose levels in normal and glucose loaded rats, and alloxan-induced diabetic rats was determined. After 10 days of treatment, blood samples were collected from rats for lipid and insulin profiling. Animals were thereafter sacrificed and the kidneys, heart, and liver were harvested for antioxidant indices assay. RESULTS: In normal rats, B. coccineus did not cause significant reduction in blood glucose. At the dose of 800 mg·kg–1, significant increase in blood glucose level was not observed 30 min. after glucose load. B. coccineus administered acutely did not generally produce significant reduction in blood glucose level in diabetic rats. Administered subacutely, the extract significantly reduced blood glucose level in diabetic rats from the 3rdday with peak effect observed at the dose of 800 mg·kg–1on the 10thday. The extract generally preserved in vivo antioxidant levels in the kidneys, heart, and liver, increased the level of high density lipoprotein and insulin, and reduced the level of triglycerides and low density lipoprotein compared to diabetic control. CONCLUSION: The findings in this study suggest that the hydroethanolic leaf extract byrsocarpus coccineus possesses antidiabetic activity possibly mediated through inhibition of intestinal glucose absorption, in vivo antioxidant activity, and enhancement of regeneration of beta cells of the pancreas and insulin secretion.

关键词： byrsocarpus coccineus Connaraceae Hypoglycemic activity Antioxidant activity Diabetes

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Ulcer protective effect of byrsocarpus coccineus leaf extract in different experimental animal models

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Journal of Coastal Life Medicine 2015年第9期 728-732页

作者： Akuodor Godwin Christian Udia Pius Monday Akpan Joseph Linus Ezeokpo Basil Chukwuma Okezie Ogwuegbu Alozie Ghasi Samuel Ikenna Nwadike Kenneth Ikechukwu Department of Pharmacology and Therapeutics Faculty of Clinical MedicineEbonyi State UniversityAbakalikiNigeria Department of Pharmacology College of Medical SciencesUniversity of CalabarCross River StateNigeria Department of Chemical Pathology Federal Teaching HospitalAbakalikiNigeria Department of Pharmacology and Therapeutics College of MedicineUniversity of NigeriaEnugu CampusNigeria

Objective:To evaluate the antiulcer activity of ethanolic leaf extract of byrsocarpus coccineus,a plant used in herbal medicine for the management of various diseases in ***:Ethanol-,acetylsalicylic acid-,histamine-and water immersion stress-induced gastric ulcers in rats were used to investigate the antiulcer activity of the leaf *** toxicity studies were also carried ***:The ethanolic leaf extract significantly(Pbyrsocarpus coccineus ethanolic leaf extract possesses potent antiulcer activity and the leaf of this plant can serve as a potential source of safe and affordable antiulcer agents.

关键词： byrsocarpus coccineus Leaves Ethanol extract Antiulcer Rats

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