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Combined Treatment with Bojungikgi-tang(buzhong yiqi decoction)and Riluzole Attenuates Cell Death in TDP-43-Expressing Cells

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Chinese Journal of Integrative Medicine 2024年第7期30卷 616-622页

作者： Eun Jin Yang Department of KM Science Research Korea Institute of Oriental MedicineDaejeonYuseong-gu34054Republic of Korea

Objective To examine the effect of combined treatment with Bojungikgi-tang(BJIGT,buzhong yiqi decoction)and riluzole(RZ)in transactive response DNA-binding protein 43(TDP-43)stress granule(SG)cells,a amyotrophic lateral sclerosis(ALS)cell line using transcriptomic and molecular *** TDP-43 SG cells were pretreated with BJIGT(100µg/mL),RZ(50µmol/L),and combined BJIGT(100µg/mL)/RZ(50µmol/L)for 6 h before treatment with lipopolysaccharide(LPS,200µmol/L).Cell viability assay was performed to elucidate cell toxicity in TDP-43 SC cells using a cell-counting kit-8(CCK8)assay *** expression levels of cell death-related proteins,including Bax,caspase 1,cleaved caspase 3 and DJ1 in TDP-43 SG cells were examined by Western blot *** autophagy-related proteins,including pmTOR/mTOR,LC3b,P62,ATG7 and Bcl-2-associated athanogene 3(Bag3)were investigated using immunofluorescence and immunoblotting *** Cell viability assay and Western blot analysis showed that combined treatment with BJIGT and RZ suppressed LPS-induced cell death and expression of cell death-related proteins,including Bax,caspase 1,and DJ1(P<0.05 or P<0.01).Immunofluorescence and immunoblotting assays showed that combined treatment with BJIGT and RZ reduced LPS-induced formation of TDP-43 aggregates and regulated autophagy-related protein levels,including p62,light chain 3b,Bag3,and ATG7,in TDP-43-expressing cells(P<0.05 or P<0.01).Conclusion The combined treatment of BJIGT and RZ might reduce inflammation and regulate autophagy dysfunction in TDP-43-induced ALS.

关键词： Bojungikgi-tang buzhong yiqi decoction transactive response DNA-binding protein 43 autophagy oxidative stress amyotrophic lateral sclerosis

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Therapeutic effects of buzhong yiqi decoction in patients with spleen and stomach qi deficiency after routine surgery and chemotherapy for colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2183-2193页

作者： Qi Hu Xiao-Pin Chen Zhi-Jun Tang Xue-Yuan Zhu Chun Liu College of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Anorectal Surgery The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Anorectal Surgery The First Traditional Chinese Medicine Hospital of ChangdeChangde 415000Hunan ProvinceChina Intensive Care Unit The First Traditional Chinese Medicine Hospital of ChangdeChangde 415000Hunan ProvinceChina

BACKGROUND According to the theory of traditional Chinese medicine(TCM),the spleen and stomach are the basis of acquired nature and the source of qi and blood *** surgery and chemotherapy,patients with colorectal cancer often develop spleen and stomach qi deficiency syndrome,leading to decreased immune *** yiqi decoction,a classic TCM prescription,has the effect of tonifying middle-jiao and invigorating qi,boosting Yang,and suppressing immune-related ***,it is widely used in the treatment of spleen and stomach qi deficiency *** To investigate the effect of buzhong yiqi decoction on spleen and stomach qi deficiency in patients with colorectal *** One hundred patients with colorectal cancer who underwent preoperative chemotherapy and laparoscopy at The First TCM Hospital of Changde from January 2022 to October 2023 were retrospectively *** patients were divided equally into control and observation *** groups underwent conventional rehabilitation surgery,and the observation group was supplemented with buzhong yiqi *** 26.0 was used for statistical ***χ2 test was used for univariate analysis;independent sample t-tests were used in all *** No significant differences were observed preoperatively in the general characteristics of the two *** days post-surgery,the abdominal distension,emaciation,loose stool,loss of appetite,and vomiting scores were significantly lower in the observation group than in the control group(P<0.05).Immune function and interleukin(IL)-10 levels in the observation group were significantly higher than those of the control group,whereas IL-6,tumor necrosis factor-α,and C-reactive protein levels,tumor biological indexes,and adverse reactions in the observation group were significantly lower than those of the control group(P<0.05).One month after surgery,the patients’quality of life in the observation group was significantly high

关键词： buzhong yiqi decoction Colorectal cancer Laparoscopic radical surgery Immune function Inflammatory mediators Spleen

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Efficacy of buzhong yiqi decoction(补中益气汤)on benign prostatic hyperplasia and its possible mechanism

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Journal of Traditional Chinese Medicine 2023年第3期43卷 533-541页

作者： JIA Lihua KUANG Haodan XU Yuan Department of urology Jinhua Hospital of TCMJinhua 321000China Zhejiang Chinese Medical University college of pharmacy Hangzhou 310053China Ningbo medical center Lihuili Hospital Ningbo 315100China

OBJECTIVE:To explored the mechanism of buzhong Yigi decoction(补中益气汤 BZYQD) in inhibiting prostatic cell proliferation ***:The compounds of BZYQD consisted with eight herbs were searched in TCMSP databases and the putative targets of BZYQD were collected in Drugbank ***,“Benign prostatic hyperplasia”(BPH) was used to find the targets based on the Gene Cards,Online Mendelian Inheritance in Man(OMIM) and Therapeutic Target Database(TTD) databases,and they were further used to collect further collect the intersection targets between BZYQD and BPH by ***,Herb-Compound-Target-Disease network was constructed by Cytoscape software and protein interaction network was built by Search tool for recurring instances of neighbouring genes(STRING) *** Ontology(GO) enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment were analyzed by Database for Annotation,Visualization and Integrated Discovery(DAVID) database to predict the mechanism of the intersection *** activated protein kinase 8(MAPK8),interleukin 6(IL-6) and quercetin were chosen to perform molecular *** 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-Htetrazolium bromide(MTT) assay was to detect the via bility of BPH-1(BPH epithelial cell line) by treated with quercetin at the concentrations of 15,30,60,120 μM for 12,24,48,72 *** production of IL-6,tumor necrosis factor-α(TNF-α),IL-1β and were m RNA expression detected by enzyme-linked immunosorbent assay kit and quantitative real-time polymerase chain *** blot was used to detect the expression of phospho-p38 mitogen-activated protein kinase(p-P38) and matrix metalloprotein-9(MMP-9).RESULTS:A total 151 chemical ingredients of 8 herbs and 1756 targets in BZYQD,105 common targets of BZYQD and BPH which mainly involving with MAPK8,IL-6,and so *** enrichment analysis got 352 GO entries(P < 0.05) which included 208 entries of biological process,64 entries of cell compon

关键词： quercetin prostatic hyperplasia network pharmacology buzhong yiqi decoction

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Clinical efficacy of buzhong yiqi decoction(补中益气汤)in the treatment of hospital-acquired pneumonia with multi-drug resistant bacteria:a prospective,randomized,multicenter controlled trial

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Journal of Traditional Chinese Medicine 2023年第5期43卷 1010-1018页

作者： XU Xiangru ZHOU Yi CHEN Gang LEI Ming ZHANG Wen WU Xinxin PU Yuting CHEN Caiyu SUN Yuting ZHOU Shuang FANG Bangjiang Department of Emergency Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China School of Basic Medical Sciences Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Intensive Care Medicine Seventh People’s Hospital of Shanghai University of Traditional Chinese MedicineShanghai 200137China Acupuncture and Massage College Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Critical Care Shanghai University of Traditional Chinese MedicineShanghai 201203China

OBJECTIVE:To evaluate the efficacy and safety of buzhong yiqi decoction(补中益气汤,BZYQ)in the treatment of hospital-acquired pneumonia(HAP)with multi-drug-resistant bacteria(MDRB).METHODS:This 28-day study was conducted at 5 clinical centers in *** eligible patients were randomly assigned(1∶1)into the intervention group(BZYQ plus conventional Western Medicine therapy)and control group(conventional Western Medicine therapy).The primary outcomes were the clinical response,clinical pulmonary infection score(CPIS),and microbiologic *** secondary outcomes were the 28-day allcause mortality(ACM),Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ)score,ventilator weaning rate,length of mechanical ventilation(MV),length of hospital stay,and changes of infection ***:Altogether 83 subjects in the intervention group and 85 subjects in the control group were *** clinical success rate(48.2%)and the pathogen eradication rate(59.0%)of the intervention group were all better than those of the control group(32.9%and 38.9%,respectively)with statistically significant differences(P0.05).The differences between two groups in ventilator weaning rate,length of hospital stay,and APACHEⅡscore were not statistically significant(P>0.05).The intervention group displayed decreases in white blood cell count,C-reactive protein,neutrophil percentage,and procalcitonin at day 28 compared with baseline(P<0.05).No serious adverse events occurred in either group during the 28-day ***:BZYQ may be an effective therapeutic option for the management of HAP with MDRB.

关键词： healthcare-associated pneumonia drug resistance multiple bacteria buzhong yiqi decoction randomized controlled trial

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Effect of buzhong yiqi decoction (补中益气汤) on Murine Liver Damage Induced by Food Allergy

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Chinese Journal of Integrated Traditional and Western Medicine 2004年第1期10卷 55-58页

作者：陈虹董阳深陈奋华纪经智陈岩峰上野幸三饭仓洋治 Department of Pediatrics The Third Hospital Affiliated to Sun Yat-Sen University of Medical SciencesGuangzhou(510630) Department of Pediatrics Showa University School of MedicineTokyo 142-0064Japan

Objective: To investigate the effect of buzhong yiqi decoction (补中益气汤, BZYQD) on liver damage induced by food allergy in mice. Methods: Nc/Jic strain mice with high levels of serum IgE were sensitized by ovalbumin (OVA), and then divided into two groups and respectively treated with BZYQD (treated group) or normal saline (model group). Samples of serum, liver tissues and small intestine were collected two weeks later, and another group of non-sensitized mice was set as the normal group. The levels of serum alanine aminotransferase (ALT) were measured with spectrophotometry. The liver tissue and small intestine were stained with hematoxylin and eosin (HE) for pathologic analysis. The liver samples were also subjected to analysis of CD4-T helper cell and cytokine (interleukin-4, IL-4, interleukin-6, IL-6) expression with immunohistochemical (avidin-biotin complex, ABC) method. Results: Serum ALT levels decreased and obvious pathologic improvements were seen in the mice treated with BZYQD. And compared with the model mice, the number of positive cells of IL-4, IL-6 and CD4 cell decreased significantly in those treated with BZYQD. Conclusion: BZYQD can effectively decrease the production of cytokines associated with allergic reaction in the liver of mice thus effective in treating liver damage caused by food allergy.

关键词： food allergy liver damage buzhong yiqi decoction

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