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Synthesis　and　Characterization　of　Multi-block(β)±butyrolactone(BL)-ethylene　Oxide(EO)　Copolymer

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Chemical Research in Chinese Universities 1998年第1期14卷 104-109页

ＳｙｎｔｈｅｓｉｓａｎｄＣｈａｒａｃｔｅｒｉｚａｔｉｏｎｏｆＭｕｌｔｉ－ｂｌｏｃｋ（β）±ｂｕｔｙｒｏｌａｃｔｏｎｅ（ＢＬ）－ｅｔｈｙｌｅｎｅＯｘｉｄｅ（ＥＯ）ＣｏｐｏｌｙｍｅｒＣＨＥＮＸｉａｎ－ｈａｉ（ＮＳＦＢｉｏ... 详细信息

ＳｙｎｔｈｅｓｉｓａｎｄＣｈａｒａｃｔｅｒｉｚａｔｉｏｎｏｆＭｕｌｔｉ－ｂｌｏｃｋ（β）±ｂｕｔｙｒｏｌａｃｔｏｎｅ（ＢＬ）－ｅｔｈｙｌｅｎｅＯｘｉｄｅ（ＥＯ）ＣｏｐｏｌｙｍｅｒＣＨＥＮＸｉａｎ－ｈａｉ（ＮＳＦＢｉｏｄｅｇｒａｄａｂｌｅＰｏｌｙｍｅｒ...

关键词： EO Oxide Copolymer butyrolactone ethylene BL

butyrolactone抗炎剂FL1003减轻下肢缺血-再灌注损伤所致急性肺损伤

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国际骨科学杂志 1998年第3期19卷 175-176页

作者：向军

组织缺血-再灌注激活全身性炎性反应引起严重急性肺损伤,其发病机理包含中性粒细胞激活及氧自由基产生。本研究检验的butyrolactone抗炎剂FL1003具有体外抗氧化性,能下调这种炎性反应及消除急性肺损伤。雄性鼠共16只分三组:组1为假手术... 详细信息

组织缺血-再灌注激活全身性炎性反应引起严重急性肺损伤,其发病机理包含中性粒细胞激活及氧自由基产生。本研究检验的butyrolactone抗炎剂FL1003具有体外抗氧化性,能下调这种炎性反应及消除急性肺损伤。雄性鼠共16只分三组:组1为假手术对照组(n=4),不予堵断血流;组2为缺血-再灌注组(n=7),肾动脉下端堵断2h随后再灌注1h,不使用药物治疗;组3为损伤治疗组(n=5),组织缺

关键词：急性肺损伤再灌注抗炎剂消炎剂(中药) 下肢缺血 FL1003 butyrolactone

Synthesis of Z and E-(2',5'-dimethoxyphenyl)-methylene-butyrolactones

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Chinese Chemical Letters 2000年第2期11卷 109-110页

作者： Yong Ying JIANG2 Zhi Yun LIN Li Ya ZHU1 (1Dept. Of medicinal chemistry, College of pharmacy, Rutgers University, Piscataway, NJ, U.S.A. Institute of Materia Medica, Peking Union Medical College and) Chinese Academy of Medical Sciences, Beijing 100050 Institute of Materia Medica Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100050 China Dept. of Medicinal Chemistry College of Pharmacy Rutgers University Piscataway NJ United States

A pair of Z and E isomers of cyclization of γ-ketoacid 7, which was prepared in six steps from 2,5-dimethoxyphenyl acetic acid 1, gave a pair of Z(20%) and E (4%) isomers of (2,5-dimethoxyphenyl)-methylene-butyrolact... 详细信息

关键词： butyrolactone γ-keto-acid lactonization ferric sulfate hydrate.

Synthesis of Cyclopropylamine with Phase Transfer Catalysis

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Journal of Central South University 2000年第2期12卷 81-83页

作者： YI Jian-ming TANG Kuo-wen REN Bi-ye XIONG Hai-ying College of Chemistry and Chemical Engineering Central South University of TechnologyChangsha 410083China Department of Chemical Engineering Yueyang Normal UniversityYueyang 414000China

Cyclopropylamine is synthesized with γ butyrolactone and isopropanol by five steps of ring opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation. Cyclization and hydrolysis are key steps in the process, and Phase Transfer Catalysis (PTC) is used in the two steps respectively. In the cyclization reaction, because solid liquid PTC, sodium hydroxide is applied instead of expensive sodium alcoholate, the reaction can be carried out in mild conditions. The optimum re action conditions are as follows: 0.03∶1∶1.5 mole ratio of BTEAC to ester to sodium hydroxide, reacting at 50 ℃ for 2 h with yield of 92%. Hydrolysis of isopropyl cyclopropanecarboxylate is accelerated by liquid liquid PTC, and the order of catalytic activity is BTEAC>BTMAC>CTMAB>TBAB. The results show that the new synthesis method is superior to those from literature and feasible for production with simple routes, mild reaction conditions, cheap materials and total yield of 52.6%.

关键词： cyclopropylamine synthesis γ butyrolactone phase transfer catalysis

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细胞周期蛋白依赖性激酶抑制剂

中国现代应用药学 2003年第5期20卷 360-363页

作者：罗蕴胡永洲浙江大学药学院药物研究所杭州310006

目的　系统介绍细胞周期蛋白依赖性激酶 (CDK)抑制剂的抗肿瘤作用。方法　对近几年国外有关CDK抑制剂的发现、构效研究及临床试验等文献进行检索和综述。结果　olomoucine,roscovitine等三取代嘌呤类化合物 ,flavopiridol及butyrolac t... 详细信息

目的　系统介绍细胞周期蛋白依赖性激酶 (CDK)抑制剂的抗肿瘤作用。方法　对近几年国外有关CDK抑制剂的发现、构效研究及临床试验等文献进行检索和综述。结果　olomoucine,roscovitine等三取代嘌呤类化合物 ,flavopiridol及butyrolac tone三类化合物具有明显的CDK抑制活性 ,对多种人类肿瘤均有疗效 ,且不良反应小。结论　细胞周期蛋白依赖性激酶(CDK)

关键词：细胞周期细胞周期蛋白依赖性激酶抑制剂肿瘤治疗olomoucine roscovitine flavopiridol butyrolactone

Screening of fungi producing butyllactone compounds and Study on the anti-inflammatory activity of butylactone compounds

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Screening of fungi producing butyllactone compounds and Stud...