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Herbal formula of bushen jianpi(补肾健脾方)combined with sorafenib inhibits hepatocellular carcinoma growth by promoting cell apoptosis and blocking the cell cycle

引用

Journal of Traditional Chinese Medicine 2021年第2期41卷 194-202页

作者： ZHOU Zhangjie LIU Xinhua WU Tingting QUE Zujue WU Zhonghua WU Weizhong FU Shujuan ZHANG Shiqiang YANG Yun JIANG Haiyan XIA Xiaoting LV Junqiang DU Boqian LI Yun LU Tao ZHANG Zhihui ZHONG Yi Oncology Department Shanghai TCM-Integrated Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Institute of vascular disease Shanghai TCM-Integrated Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Science and Technology Experimental Center Shanghai University of Traditional Chinese MedicineShanghai 201203China Tumor Institute of Traditional Chinese Medicine Longhua HospitalShanghai 200032China Institute of Liver Cancer Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China

OBJECTIVE:To investigate the efficacy of an herbal formula of bushen jianpi(补肾健脾方,BSJP)combined with sorafenib on hepatocellular carcinoma(HCC)in vitro and in vivo,and to study the underlying mechanisms of ***:BSJP,a mixture of 12 raw herbs,was extracted in 70%alcohol/30%water and freeze-dried into a *** in vitro effects of BSJP alone,sorafenib alone,and their combination on cell survival,apoptosis,and cell cycle distribution were evaluated in HCC cell lines HCCLM3,HepG2,and *** expression of B-cell lymphoma-2(Bcl-2),caspase-3,and caspase-9 in HCCLM3 cells was measured using Western blots after drug *** in vivo effects of BSJP and sorafenib were evaluated in a tumor surgical resection model using 4-week old male athymic BALB/c nude mice injected with HCCLM3 *** analysis of tumor tissues was performed to evaluate the effects of BSJP alone,sorafenib alone,and their combination on the expression of caspase-3,caspase-9,and ***:BSJP decreased the survival rate of HCC cell lines,and the combination of BSJP and sorafenib further decreased the survival *** significantly promoted cell apoptosis and blocked cell-cycle progression in HCCLM3,HepG2,and SMMC-7721 cells in a dose-dependent ***,the administration of BSJP and sorafenib inhibited the growth of HCCLM3 cell xenografts in nude mice,with no reduction in body *** vivo and in vitro experiments showed that BSJP combined with sorafenib could significantly decrease the expression of ***:Our findings suggest that the herbal formula of BSJP is a potential HCC antitumor agent.

关键词： carcinoma,hepatocellular cell apoptosis cell cycle sorafenib bushen jianpi

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