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Experimental models of high-risk bowel anastomosis in rats:A systematic review

World Journal of Experimental Medicine 2024年第2期14卷 114-131页

作者： Georgios Ntampakis Manousos-Georgios Pramateftakis Elissavet Anestiadou Stefanos Bitsianis Orestis Ioannidis Chryssa Bekiari George Koliakos Maria Karakota Anastasia Tsakona Angeliki Cheva Stamatios Angelopoulos Fourth Department of Surgery Medical SchoolAristotle University of ThessalonikiThessaloniki 57010Greece Laboratory of Anatomy and Histology School of Veterinary MedicineFaculty of Health SciencesAristotle University of ThessalonikiThessaloniki 54124Greece Experimental and Research Center Papageorgiou General Hospital of ThessalonikiThessaloniki 56403Greece Laboratory of Biochemistry Faculty of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece Department of Pathology Faculty of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece

BACKGROUND Anastomotic leaks remain one of the most dreaded complications in gastrointestinal surgery causing significant morbidity,that negatively affect the patients’quality of *** studies play an important role in understanding the pathophysiological background of anastomotic healing and there are still many fields that require further *** drawn from these studies can lead to interventions or techniques that can reduce the risk of anastomotic leak in patients with high-risk *** the advances in experimental protocols and techniques,designing a high-quality study is still challenging for the investigators as there is a plethora of different models *** To review current state of the art for experimental protocols in high-risk anastomosis in *** This systematic review was performed according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** identify eligible studies,a comprehensive literature search was performed in the electronic databases PubMed(MEDLINE)and Scopus,covering the period from conception until 18 October *** From our search strategy 102 studies were included and were categorized based on the mechanism used to create a high-risk *** of assessing anastomotic healing were extracted and were individually *** Anastomotic healing studies have evolved over the last decades,but the findings are yet to be translated into human *** is a need for high-quality,well-designed studies that will help to the better understanding of the pathophysiology of anastomotic healing and the effects of various interventions.

关键词： High-risk anastomosis Rats Experimental models Bowel Colon Anastomotic leak Colon resection Inflammatory bowel disease Intra-abdominal sepsis bursting pressure

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A biodegradable magnesium surgical staple for colonic anastomosis: In vitro and in vivo evaluation

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Bioactive Materials 2023年第4期22卷 225-238页

作者： Yue Zhang Jian Cao Mengmeng Lu Yi Shao Kewei Jiang Xiaodong Yang Xiaoyu Xiong Shan Wang Chenglin Chu Feng Xue Yingjiang Ye Jing Bai Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing211189China Institute of Biomedical Devices(Suzhou) Southeast UniversitySuzhou215163China Department of Gastroenterological Surgery Peking University People’s HospitalBeijing100044China Department of Oral Implantology The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing210029China Jiangsu Key Laboratory for Light Metal Alloys Nanjing211212China

Staplers have been widely used in the clinical treatment of gastrointestinal ***,the current titanium(Ti)staple will remain in the human body permanently,resulting in some adverse *** this study,we developed a type of biodegradable staple for colonic anastomosis using 0.3 mm diameter magnesium(Mg)alloy *** wire surface was modified by micro-arc oxidation treatment(MAO)and then coated with poly-L-lactic acid(PLLA)to achieve a moderate degradation rate matching the tissue healing *** results of tensile tests on isolated porcine colon tissue anastomosed by Mg and Ti staples showed that the anastomotic property of Mg staples was almost equal to that of Ti *** in vitro degradation tests indicated the dual-layer coating effectively enhanced the corrosion resistance and maintained the tensile force of the coated staple stable after 14-day immersion in the simulated colonic fluid(SCF).Furthermore,24 beagle dogs were employed to conduct a comparison experiment using Mg-based and clinical Ti staples for 90-day implantation by ent-to-side anastomosis of the *** integrated structure of Mg-based staples was observed after 7 days and completely degraded after 90 *** animals did not have anastomotic leakage and stenosis,and 12 dogs with Mg-based staples fully recovered after 90 days without differences in visceral ion levels and other side *** favorable performance makes this Mg-based anastomotic staple an ideal candidate for colon reconstruction.

关键词： Gastrointestinal tract Degradation bursting pressure Anastomotic stoma Colon reconstruction

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