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Study on Quality Standard of Zhuang Medicine buddlejae flos

Medicinal Plant 2023年第2期14卷 27-33页

作者： Tong LI Zhengsan LING Xin XIE Liyuan LI Haifeng WEI Suoyi HUANG Shiyou ZHOU Lixiang LU Tingting HE Ran CHEN Yue LI Zheng LIU Jinchi LIU School of Basic Medical Sciences Youjiang Medical University for NationalitiesBaise 533000China Key Laboratory of Molecular Pathology of Hepatobiliary Diseases Youjiang Medical University for NationalitiesBaise 533000China School of Pharmacy Youjiang Medical University for NationalitiesBaise 533000China Guangxi Colleges and Universities Key Laboratory of Characteristic Ethnic Medicine of Youjiang Valley Youjiang Medical University for NationalitiesBaise 533000China Affiliated Hospital of Youjiang Medical University for Nationalities Baise 533000China

[Objectives]This study was conducted to explore the quality control method and establish the quality standard of Zhuang medicine buddlejae flos.[Methods]The microscopic identification method was adopted to identify the characters and microscopic characteristics of dried buddlejae flos in combination with traditional *** moisture,ash,acid-insoluble components and extracts of buddlejae flos were determined with reference to general rules of Chinese Pharmacopoeia(2015 edition).TLC identification was *** chromatography-mass spectrometry(LC-MS)was used to determine the contents of linarin and verbascoside in buddlejae flos,and gas chromatography-mass spectrometry(GC-MS)was adopted to detect pesticide residues in buddlejae *** metal elements As,Cd and Pb were detected by inductively coupled plasma mass spectrometry(ICP-MS).[Results]The established method is simple and *** spots were observed on the thin layer chromatograms,and the resolution was *** average value of moisture content was 12.24%;the average value of ash content was 5.1%;the average value of acid-insoluble content was 7.5%;and the average value of extract content was 27.3%.The regression equation of rutin in buddlejae flos was y=11.896x-0.0049,R^(2)=0.9996,and the contents of linarin and verbascoside were 5680 and 2080 mg/kg,*** pesticide residues and heavy metals were detected in the medicinal materials of buddlejae flos.[Conclusions]This study can provide reference for the quality standard control of Guangxi Zhuang medicine buddlejae flos.

关键词： Zhuang Medicine buddlejae flos LC-MS GC-MS ICP-MS Quality standards Content determination

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Molecular mechanism of Mimenghua Granules in treating dry eye

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Medical Data Mining 2021年第4期4卷 33-41页

作者： Dong-Hua Liu Peng-Fei Jiang Pei Liu Chen Ou Jun Peng Hou-Pan Song Qing-hua Peng Hunan University of Chinese Medicine Changsha 410208China First Affiliated Hospital of Hunan University of Chinese Medicine Changsha 410007China

Objective:To explore the molecular mechanism of Mimenghua Granules in treating dry eye based on network pharmacology and bioinformatics ***:Screening and prediction of possible blood-inducing active ingredients and action target of Mimenghua Granules through Traditional Chinese Medicine Systems Pharmacology database and analysis platform;mining dry eye-related diseases through disease gene database,gene target;use the functional protein combined network database STRING to draw the component-target and disease-target PPI networks,and extract the intersection of these two networks;use DAVID database analysis to screen key targets and analyze the mechanism of ***:A total of 593 active ingredients related to Mimenghua Granules were retrieved from the Traditional Chinese Medicine Systems Pharmacology database,and 59 blood active ingredients were obtained by screening based on pharmacokinetic parameters,and 680 targets related to these ingredients were retrieved;from disease genes,the database searches for 47 genes directly related to dry eye;3 key genes(ICAM1,IFNG,and IL-6)were obtained after the intersection of the component target and disease target PPI network;these genes are mainly involved in natural killer cell-mediated cytotoxicity,Jak-STAT signaling pathway,and Cytokine-cytokine receptor ***:The mechanism of Mimenghua Granules in treating dry eye is related to the interaction of cytotoxic pathway,Jak-STAT signal pathway,and *** key gene targets are ICAM1,IFNG,and IL-6.

关键词： Mimenghua Granules buddlejae flos Lycii Fructus Chrysanthemi flos Dry eye Network pharmacology Bioinformatics

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