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Surviving And Replicating Inside The macrophage

Surviving And Replicating Inside The Macrophage

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第十届全国免疫学学术大会

作者： yumei zhou Yuanqiang Zheng Sen Xu Caixia Wang Zhenli Chen Zhe Chen Yanchun Shi Beijing University of Chinese Medicine Inner Mongolia Medical University

brucella,a gram-negative bacteria,is a highly infectious disease of pandemic potential reporting over 500,000 new human cases *** is the causative agent of the zoonotic disease of brucellosis and it can survive and replicate within the host macrophages,which can escape from the subversion of the immune system to make treatment and diagnosis *** most effective measure to control brucellosis is the vaccination of the host *** are some licensed vaccines for prevention of animals while it is unable to distinguish the vaccinated from the natural infected *** works as the first line of defense of the innate immune response against the invading of *** order to avoid the destruction of macropage,brucella can avoid those defense mechanisms to survive and replicate inside these *** strategies include(1)rapid escape from the phagosome to gain entry into the cytosol;(2)stalling of phagosome maturation at various stages preceding fusion with lysosomes;(3)survival and replication in a degradative phagolysosomal environment.(4)complete or partial avoidance of the *** processes require microbial factors to interfere with macrophage functions,circumvent macrophage defense mechanisms and ensure its intracellular survival over its *** brucella virulent factors,such as lipopolysaccharide,type IV secretion system and the Bvr R/Bvr S two-component system,have been identified to be critical in the intracellular process of brucella inside the *** survive in the microphages,brucella have the ability a to control its own intracellular trafficking to avoid lysosomal degradation,multiply extensively within a host cell without restricting basic cellular functions or inducing programmed cell *** this review,I will discuss how the brucella can escape the detection by the host immune system and the mechanism of the brucella surlival and replication in the microphages.

关键词： brucella brucellosis survive macrophage

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