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Maternal supplementation with mulberry-leaf flavonoids improves the development of skeletal muscle in the offspring of chickens

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ANIMAL NUTRITION 2024年第3期18卷 72-83页

作者： Huang, Zhenwu Dai, Hongjian Li, Simeng Wang, Zhe Wei, Quanwei Ning, Zhonghua Guo, Yuming Shi, Fangxiong Lv, Zengpeng China Agr Univ Coll Anim Sci & Technol State Key Lab Anim Nutr & Feeding Beijing 100193 Peoples R China Nanjing Agr Univ Coll Anim Sci & Technol Nanjing 210095 Peoples R China Chinese Acad Agr Sci Inst Anim Sci State Key Lab Anim Nutr & Feeding Beijing 100193 Peoples R China Aksu Vocat Tech Coll Sch Bioengn Aksu 843000 Peoples R China

The development of skeletal muscle is a crucial factor in determining the meat yield and economic benefits of broiler production. Recent research has shown that mulberry leaves and their extracts can be used to significantly improve the growth performance of livestock and poultry. The present study aims to elucidate the mechanisms involved in the regulation of skeletal muscle development in broiler offspring by dietary mulberry-leaf flavonoids (MLF) supplementation from the perspective of maternal effect theory. A total of 270 Qiling broiler breeder hens were randomly assigned to 3 treatments with different doses of MLF (0, 30, 60 mg/kg) for 8 weeks before collecting their fertilized eggs. The chicken offspring at 13 and 19 d of embryonic stage, and from 1 to 28 d old after hatching were included in this study. The results showed that maternal supplementation increased the breast muscle weight and body weight of the offspring at the embryo and chick stages (P < 0.05). This was followed by increased cross-sectional area of pectoral muscle fibres at 14 d (P < 0.05). Further determination revealed a tendency towards increased serum levels of insulin-like growth factor 1 (IGF-1) (P = 0.092) and muscle fibre count (P = 0.167) at 1 d post-hatching following maternal MLF treatment, while serum uric acid (UA) was decreased at 14 d after hatching (P < 0.05). Moreover, maternal MLF supplementation significantly up-regulated the mRNA expression of the myogenic regulatory factor Myf5 in skeletal muscle at the both embryonic and growth stages (P < 0.05). The relative abundance of the downstream protein of BMPR2, Smad1 and p-Smad1/5/9 in the TGF beta signalling pathway was significantly increased by maternal MLF treatment. Meanwhile, the increased expression of the target protein p-mTOR in the breast muscle of the offspring chicks is in accordance with the improved growth rate of the breast and the body. In conclusion, maternal MLF supplementation can promote muscle protein metab

关键词： broiler breeder hen Mulberry-leaf flavonoids Offspring Protein metabolism Skeletal muscle GROWTH-PERFORMANCE IMMUNE FUNCTION HYPERTROPHY LEAVES MECHANISMS REGULATOR PATHWAY EMBRYO DIETS BONE

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