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Mass Spectrometry-Based Human breath analysis:Towards COVID-19 Diagnosis and Research

Journal of analysis and Testing 2021年第4期5卷 287-297页

作者： Zi-Cheng Yuan Bin Hu Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air Pollution Institute of Mass Spectrometry and Atmospheric EnvironmentJinan UniversityGuangzhou 510632China

COVID-19 is a highly contagious respiratory disease that can be infected through human exhaled breath.Human breath analysis is an attractive strategy for rapid diagnosis of COVID-19 in a non-invasive way by monitoring breath biomarkers.Mass spectrometry(MS)-based approaches off er a promising analytical platform for human breath analysis due to their high speed,specificity,sensitivity,reproducibility,and broad coverage,as well as its versatile coupling methods with different chromatographic separation,and thus can lead to a better understanding of the clinical and biochemical processes of COVID-19.Herein,we try to review the developments and applications of MS-based approaches for multidimensional analysis of COVID-19 breath samples,including metabolites,proteins,microorganisms,and elements.New features of breath sampling and analysis are highlighted.Prospects and challenges on MS-based breath analysis related to COVID-19 diagnosis and study are discussed.

关键词： COVID-19 SARS-CoV-2 breath analysis breath sampling Multidimensional analysis Mass spectrometry

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breath-by-breath measurement of exhaled ammonia by acetonemodifier positive photoionization ion mobility spectrometry via online dilution and purging sampling

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Journal of Pharmaceutical analysis 2023年第4期13卷 412-420页

作者： Lu Wang Dandan Jiang Lei Hua Chuang Chen Dongming Li Weiguo Wang Yiqian Xu Qimu Yang Haiyang Li Song Leng CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Health Management Center The Second Affiliated Hospital of Dalian Medical UniversityDalian116023China University of Chinese Academy of Sciences Beijing100049China Dalian Key Laboratory for Online Analytical Instrumentation Dalian116023China Dalian Engineering Research Center of breath Diagnostic Technology Dalian116023China

Exhaled ammonia(NH_(3))is an essential noninvasive biomarker for disease diagnosis.In this study,an acetone-modifier positive photoionization ion mobility spectrometry(AM-PIMS)method was developed for accurate qualitative and quantitative analysis of exhaled NH_(3)with high selectivity and sensitivity.Acetone was introduced into the drift tube along with the drift gas as a modifier,and the characteristic NH_(3)product ion peak of(C_(3)H_(6)O)_(4)NH_(4)^(+)(K_(0)=1.45 cm^(2)/V·s)was obtained through the ion-molecule reaction with acetone reactant ions(C_(3)H_(6)O)_(2)H^(+)(K_(0)=1.87 cm^(2)/V·s),which significantly increased the peak-to-peak resolution and improved the accuracy of exhaled NH_(3)qualitative identification.Moreover,the interference of high humidity and the memory effect of NH_(3)molecules were significantly reduced via online dilution and purging sampling,thus realizing breath-by-breath measurement.As a result,a wide quantitative range of 5.87-140.92μmol/L with a response time of 40 ms was achieved,and the exhaled NH_(3)profile could be synchronized with the concentration curve of exhaled CO_(2).Finally,the analytical capacity of AM-PIMS was demonstrated by measuring the exhaled NH_(3)of healthy subjects,demonstrating its great potential for clinical disease diagnosis.

关键词： Photoionization ion mobility spectrometry Acetone modifier Exhaled ammonia breath analysis

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Sensor Evaluation in a breath analysis System

Sensor Evaluation in a Breath Analysis System

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中国中西医结合学会第八届全国诊断学术会议

作者： Ke Yan David Zhang Graduate School at Shenzhen Tsinghua University Department of Computing Hong Kong Polytechnic University

breath analysis systems contain arrays of correlated chemical sensors.For such systems,sensor selection is needed.From the process of sensor selection,some insight behind the performance of different sensor arrays can be gotten.Thus,we can know more about the sensors,which could help us with the selection work in turn.In this paper,a breath analysis system for diabetes diagnosis with 16 sensors is described.Based on this system,several methods are proposed to evaluate the importance,unique discriminant information and redundancy of each sensor.They are based on the results of exhaustive sensor selection.These methods are made convenient to observe and draw intuitive conclusions.They are applied to the breath analysis system and some useful discoveries about the sensors in the system are made accordingly.

关键词： chemical sensor sensor evaluation breath analysis diabetes diagnosis enose

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Adsorptive carbon-based materials for biomedical applications

Engineered Regeneration

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Engineered Regeneration 2022年第4期3卷 352-364页

作者： Xiaomin Ye Qihui Fan Luoran Shang Fangfu Ye Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Shanghai Xuhui Central Hospital Zhongshan-Xuhui Hospitaland the Shanghai Key Laboratory of Medical Epigeneticsthe International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325000China

Adsorption or enrichment has been an indispensable and important measure in biomedical engineering since it is promising in diagnosis and treatment of complex diseases.The ongoing development in this arena starves for exploration of outstanding adsorptive materials.As an excellent candidate for adsorption or enrichment carriers,carbon-based material has demonstrated unique superiority in biomedical arena owing to its integrated charac-teristics.Herein,we review the lasted advance in adsorptive carbon-based materials for biomedical application with emphasis on carbon nanotubes(CNTs)-based,graphene-based,and biomass/polymer-based ones.We begin with the classification of different carbon-based materials and elaborate the respective preparation approaches that are utilized to realize optimized microstructure and physicochemical property.Afterwards,we introduce the different applications of carbon-based materials in biomedical arena,including blood purification,enrichment of glycopeptide and phosphopeptide,and breath analysis.Finally,we present a concise summary and give an outlook of this arena.

关键词： CNTs-base Graphene-base Biomass/polymer-based Blood purification Enrichment of glycopeptide/phosphopeptide breath analysis

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Changes in oral trace gas concentrations following orthognathic surgery and intermaxillary fixation: a case study using selected ion flow tube mass spectrometry

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International Journal of Oral Science 2011年第3期3卷 160-164页

作者： Brian M. Ross Division of Medical Sciences at the Northern Ontario School of Medicine in Thunder Bay Ontario MS 3002 Canada

Orthognathic surgery is frequently accompanied by intermaxillary fixation. Intermaxillary fixation impedes the maintenance of effective oral hygiene and prolonged fixation can result in periodontal disease. A potential shorter term effect is the generation of oral malodour. It is unclear, however, as to how the production of malodorous compounds in the oral cavity is altered post-surgery. Oral air concentration of sulphur containing compounds, short chain organic acids, ammonia, isoprene and acetone were measured using selected ion flow tube-mass spectrometry in a patient who had undergone orthognathic surgery with subsequent intermaxillary fixation. Total sulphide levels rose approximately 5-fold during fixation with metal ties, with smaller increases recorded for the other compounds measured with the exception of isoprene which remained close to baseline levels. Organic acid levels declined markedly once elastic ties had replaced metal ties, with a lesser reduction being observed in sulphide levels, with both declining further after the commencement of a chlorhexidinecontaining mouthwash. These data suggest that bacterial generation of a variety of malodorous compounds increases markedly following intermaxillary fixation. This single case also suggests that the use of elastic ties and effective oral hygiene techniques, including the use of chlorhexidine mouthwash, may help ameliorate such post-surgical effects.

关键词： oral malodour halitosis oral hygiene breath analysis organic acids sulphides mass spectrometry

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