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Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast-conserving therapy

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Cancer Communications 2018年第1期38卷 410-420页

作者： Fuh Yong Wong Wei Ying Tham Wen Long Nei Cindy Lim Hui Miao Division of Radiation Oncology National Cancer Centre Singapore11 Hospital DriveSingapore 169610Singapore Saw Swee Hock School of Public Health National University of SingaporeSingaporeSingapore

Background:Asians are diagnosed with breast cancer at a younger age than Caucasians *** studied the effect of age on locoregional recurrence and the survival of Asian breast cancer patients treated with breast-conserving ***:Medical records of 2492 patients treated with breast-conserving therapy between 1989 and 2012 were *** Kaplan-Meier method was used to estimate locoregional recurrence,breast cancer-free survival,and breast cancer-specific survival *** rates were then compared using log-rank *** and age were modeled by Cox proportional *** polynomials were then used to test for non-linear relationships between age and ***:Patients≤40 years old were more likely to have locoregional recurrence than were older patients(Hazard ratio[HR]=2.32,Pbreast cancers,compared with 8%for those with triple-negative ***,breast cancer-free survival rates increased year-on-year by 4%versus 8%for luminal-type and triple-negative cancers,*** cancer-spe-cific survival rates increased with age by 5%*** breast cancer-free survival and breast cancer-specific survival rates in patients with luminal cancers exhibited a non-linear(“L-shaped”)relationship-where decreasing age at presentation was associated with escalating risks of relapse and *** influence of age on overall survival was confounded by competing non-cancer deaths in older women,resulting in a“U-shaped”***:Young Asian breast cancer patients have a continuous year-on-year increase in rates of disease relapse and cancer deaths compared with older patients with no apparent threshold.

关键词： breast cancer breast-conserving therapy Locoregional recurrence breast cancer-specific survival breast cancer-free survival Younger age

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Is surgical axillary staging necessary in women with T1 breast cancer who are treated with breast-conserving therapy?

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Cancer Communications 2019年第1期39卷 233-244页

作者： Jin Wang Hailin Tang Xing Li Cailu Song Zhenchong Xiong Xi Wang Xiaoming Xie Jun Tang Department of breast Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterNo.651 Dongfeng East RoadYuexiu DistrictGuangzhou 510060GuangdongP.R.China

Background:In the post-Z0011 trial era,the need to perform surgical axillary staging for early-stage breast cancer patients,who are treated with breast-conserving therapy(BCT),is being *** conducted a retrospective cohort study using the Surveillance,Epidemiology,and End Results(SEER)database to evaluate the safety of waiving surgical axillary staging in patients with T1 breast cancer treated with ***:A total of 166,615 eligible patients diagnosed between 2000 and 2012 were divided into staging(sentinel lymph node biopsy or axillary lymph node dissection)and non-staging(no lymph node examined or only needle aspiration biopsy of lymph nodes)*** score matching(PSM)was performed to balance disparities between the two *** analysis with the Cox proportional hazards model was used to assess factors related to breast cancer-specific survival(BCSS).Results:Although the tumor size at time of presentation was decreasing over years,the rate of surgical axillary stag-ing increased from 93.3%to 96.9%.The 5-year BCSS rates of the whole cohort(before PSM)and matched cohort(after PSM)were 98.0%and 97.5%.Within the matched cohort,the BCSS was significantly longer in the staging group than in the non-staging group(P0.05).Race,marital status,hormone receptors,and chemotherapy were not associated with the favorable impact of surgical axillary staging on BCSS(P>0.05).Conclusion:Although surgical axillary staging remains important for T1 breast cancer patients treated with BCT,it might be unnecessary for patients with old age,small tumor,grade I disease,or favorable histological types.

关键词： Surgical axillary staging T1 breast cancer breast-conserving therapy Surveillance Epidemiology and End Results

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Quantitative Assessment of Chronic Skin Reactions Including Erythema and Pigmentation after breast conserving therapy

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Advances in breast Cancer Research 2016年第3期5卷 121-128页

作者： Miho Kawashima Miwako Nozaki Kazuhiro Komazaki Ryuko Yamamuro Kazuo Ishizuna Makoto Kojima Department of Radiology Dokkyo Medical University Koshigaya Hospital Saitama Japan breast Center Dokkyo Medical University Koshigaya Hospital Saitama Japan

Purpose: To evaluate long-term skin reactions following breast-conserving therapy by using the melanin-erythema index meter. Patients and Methods: 164 patients were followed for at least three years after breast-conserving therapy. For both the erythema and the melanin indices, the ratio of the irradiated-side index to the non-irradiated-side index was calculated. The time course of index ratios alternation was examined. Influences from additional therapies and patients’ age were also evaluated. Result: Both erythema and melanin index ratios of the breast skin were recovered to pre-radiation level three years after radiotherapy. However, both index ratios of the area administrated with 10-Gy boost irradiation were still high even after five years after radiotherapy. Endocrine therapy, chemotherapy and age had no significant influence on skin color reactions three years after radiotherapy. Conclusion: Quantitative assessment using the melanin-erythema index meter demonstrated that chronic skin reactions following breast conserving therapy had recovered to pre-radiation level for three years after irradiation except for the 10-Gy boost irradiated area.

关键词： breast Cancer Erythema Index Melanin Index breast-conserving therapy

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