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Presentation of Axillary Metastases from Occult breast Carcinoma

Chinese Journal of Clinical Oncology 2007年第1期4卷 1-5页

作者： Xin Wang First Department of breast Tumor TianjinMedical University Cancer institute and Hospital Tianjin 300060 China.

Axillary presentation from occult breast cancer is uncommon and continues to be a diagnostic and therapeutic challenge to physicians. Once the diagnosis of adenocarcinoma metastatic to an axillary lymph node has been confi rmed, a preoperative workup should be done. The current experience is based on several relatively small retrospective reviews and case reports. It is diffi cult to determine the best management of occult breast cancer. However, treatment of axillary lymph node dissection is recommended for local control and complete staging information. Treatment of breast should be a choice between breast conservation with whole-breast radiotherapy and mastectomy. Adjuvant systemic treatment should be offered.

关键词： occult breast cancer axiUary metastases mastectomy breast conservation radiotherapy.

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Neoadjuvant chemotherapy in patients with stages II and III breast cancer

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Chinese Medical Journal 2009年第24期122卷 2993-2997页

作者： YUAN Zhu QU Xiang ZHANG Zhong-tao WANG Yu Department of General Surgery Beijing Friendship HospitalCapital Medical University Beijing 100050 China

Background Neoadjuvant chemotherapy has been used as a primary treatment for locally advanced or inflammatory breast cancer, and recently extended to operable breast cancer. However, only a few studies have published data concerning the outcomes of patients with stages II and III breast cancer after neoadjuvant chemotherapy. Methods This study retrospectively investigated the clinical value of neoadjuvant chemotherapy for patients with stages II and III breast cancer. The patients in Group 1 （n=54） were treated with neoadjuvant chemotherapy, followed by definitive surgery and adjuvant therapy. The patients in Group 2 （n=-43） initially received definitive surgery, followed by adjuvant chemotherapy and other therapies. The operability rates for breast conservation and dermatoplasty were observed in Group 1 after neoadjuvant chemotherapy. After follow-up, the recurrence and overall and disease-free survival rates of the two groups were analyzed. Results Neoadjuvant chemotherapy increased the operability rates for breast conservation from 17.1% to 40.0% in stage II （P=0.034） and 0% to 12.6% in stage III （P=0.016）, and decreased the dermatoplasty rates from 17.1% to 2.8% in stage II （P=0.046） and 28.1% to 8.1% in stage Ill （P=0.026）. After a median follow-up of 46.8 months, there were 11 deaths and 13 recurrences in Group 1, and 15 deaths and 19 recurrences in Group 2. The overall and disease-free survival rates of stage III disease were significantly higher in Group 1 than in Group 2 （68.4% vs 31.2%, P=0.028, and 63.2% vs 25.0%, P=0.024, respectively）. There were no significant differences in the overall and disease-free survival rates of stage II disease for Group 1 compared with Group 2 （85.7% vs 85.2%, P=0.953, and 80.6% vs 74.1%, P=0.400, respectively）. Conclusions Neoadjuvant chemotherapy resulted in increased operability for breast conservation and decreased dermatoplasty. Neoadjuvant chemotherapy exhibited better recurrence control, and overall and disease-free s

关键词： neoadjuvant chemotherapy breast cancer breast conservation overall survival

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Inverted T-Shaped Flap Nursing after the Reverse Double V-Shaped Mastoconstriction Suspension for breast Cancer

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Advances in breast Cancer Research 2021年第4期10卷 165-172页

作者： Linfei Liu Lijuan Zhang Yuanzhen Luo Xuehui Zeng Rong Chen State Key Laboratory of Oncology in South China Guangzhou China Collaborative Innovation Center for Cancer Medicine Guangzhou China Department of breast Cancer Sun Yat-sen University Cancer Center Guangzhou China

Objective: To explore the inverted T-shaped flap nursing after breast-conserving surgery combined with the reverse double V-shaped mastoconstriction suspension for breast cancer, and summarizes the nursing methods and experience. Method: 5 patients who underwent reverse double V-shaped mastoconstriction suspension and formed inverted T-shaped flap incision were selected from the same medical group in the Department of Breast Cancer of Sun Yat-sen University’s Cancer Center from February 1, 2019 to April 30, 2019, and they were evaluated for the recovery of blood supply of skin flap, sensory function of nipple and areola, breast satisfaction, etc. Results: Among the 5 patients in this group, the flaps of them all survived smoothly. The one-year follow-up after the operation showed that they were satisfied with the appearance of the breast after the operation, with normal sensory function, and no secondary sagging. Conclusion: The most important thing about the inverted T-shaped flap after the reverse double V-shaped mastoconstriction suspension for breast cancer is the blood supply. Close observation of the condition of the skin flap after the operation, strengthening the care of the skin flap, and preventing infection are the keys to the success of the operation.

关键词： breast Cancer breast conservation Mastoconstriction Suspension Flap Nursing

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Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence

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World Journal of Clinical Oncology 2020年第1期11卷 20-30页

作者： Juhi M Purswani Fauzia Shaikh S Peter Wu Jennifer Chun Kim Freya Schnabel Nelly Huppert Carmen A Perez Naamit K Gerber Department of Radiation Oncology New York University School of MedicineNew YorkNY 10016United States Department of Surgery New York University School of MedicineNew YorkNY 10016United States

BACKGROUND Patients with an in-breast tumor recurrence(IBTR)after breast-conserving therapy have a high risk of distant metastasis and disease-related *** clinical parameters that increase risk for recurrence after IBTR remains a *** To describe primary and recurrent tumor characteristics in patients who experience an IBTR and understand the relationship between these characteristics and disease *** Patients with stage 0-II breast cancer treated with lumpectomy and adjuvant radiation were identified from institutional databases of patients treated from 2003-2017 at our *** survival(OS),disease-free survival,and local recurrence-free survival(LRFS)were estimated using the Kaplan Meier *** identified patients who experienced an isolated *** of hormone receptor status and location of tumor from primary to recurrence was *** effect of clinical and treatment parameters on disease outcomes was also *** We identified 2164 patients who met the eligibility *** median follow-up for all patients was 3.73[interquartile range(IQR)2.27-6.07]***-year OS was 97.7%(95%CI:96.8%-98.6%)with 28 deaths;5-year LRFS was 98.0%(97.2-98.8)with 31 *** identified 37 patients with isolated IBTR,19(51.4%)as ductal carcinoma in situ and 18(48.6%)as invasive disease,of whom 83.3%had an in situ *** time from initial diagnosis to IBTR was 1.97(IQR:1.03-3.5)*** information was available for 30 of 37 *** whole-breast dose was 40.5 Gy and 23 patients received a boost to the tumor ***-five of thirty-two(78.1%)patients had concordant hormone receptor status,HER-2 receptor status,and estrogen receptor(ER)(P=0.006)and progesterone receptor(PR)(P=0.001)status from primary to IBTR were significantly *** were no observed changes in HER-2 status from primary to *** concordance between quadrant of primary to IBTR was 10/19[(62.2%

关键词： Ipsilateral breast tumor recurrence breast conservation Adjuvant radiation

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