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Rapid printing of 3D porous scaffolds for breast reconstruction

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Bio-Design and Manufacturing 2023年第6期6卷 691-703页

作者： Pengcheng Zhao Biling Wang Lu Wang Zexin Fu Jun Hu Yande Liu Ji Wang Yong He School of Mechatronics and Vehicle Engineering East China Jiaotong UniversityNanchang 330013China Center for Plastic and Reconstructive Surgery Department of Plastic and Reconstructive SurgeryZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China

Prosthesis implantation and fat transplantation are common breast *** general,prosthesis implantation alone does not achieve a realistic enough appearance,and fat transplantation alone is difficult to achieve in the correct *** date,no reports have focused on methods of combining fat with implanted prostheses for breast *** a newly designed bionic ink(i.e.,polyether F127 diacrylate(F127DA)&poly(ethylene glycol)diacrylate(PEGDA))and projection-based three-dimensional bioprinting(PBP),we report the development of a new method for printing porous *** was used to improve the printing precision of the prosthesis by increasing the gel point of F127DA and reducing the impact of external *** compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural ***,stromal vascular fraction gel(SVF-gel),a human fat extract,was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose *** were implanted subcutaneously in nude mice to observe their biological *** 14 and 28 days of observation,the prosthesis showed good biocompatibility,and adipose tissues grew well in and around the *** result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material.

关键词： Projection-based 3D bioprinting(PBP) F127DA breast reconstruction Fat transplantation

Multi-center investigation of breast reconstruction after mastectomy from Chinese Society of breast Surgery:A survey based on 31 tertiary hospitals(CSBrS-004)

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Chinese Journal of Cancer Research 2021年第1期33卷 33-41页

作者： Feng Xu Chuqi Lei Heng Cao Jun Liu Jie Li Hongchuan Jiang Chinese Society of breast Surgery Department of breast Surgery Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China 不详

Objective:Multi-center data on the current status and trends of breast reconstruction after mastectomy in China are ***,we conducted a cross-sectional survey to investigate the current clinical practice pattern of postmastectomy breast reconstruction among Chinese female patients with breast ***:A standardized questionnaire used to collect information on breast reconstruction among females diagnosed with breast cancer was distributed by 31 members of the Chinese Society of breast Surgery between January 1,2018 and December 31,*** was collected on tumor characteristics,treatment,mesh application,nipple-areola complex(NAC)preservation,postoperative complications,bilateral reconstruction,patient satisfaction and local *** overall rate of breast reconstruction was assessed,and the characteristics were compared across patient groups with different reconstruction ***:A total of 1,554 patients underwent breast reconstruction after total mastectomy,with a reconstruction rate of 9.6%.Among them,1,190 were implant-based,and 262 underwent autologous reconstructions,while 102 cases underwent a combination of *** who underwent implant-based reconstruction were younger than those who received autologous reconstruction(40.1±4.6 vs.45.0±5.9,P=0.004).Compared to patients with autologous reconstruction,mesh application(25.5%vs.6.5%),NAC preservation(51.8%vs.40.5%)and reconstruction failure(1.8%vs.0)were more frequently reported among those with implant-based *** was no significant difference in general satisfaction across three reconstruction approaches,though patients with autologous reconstruction reported the highest aesthetic satisfaction among the three groups(P=0.044).Conclusions:Implant-based breast reconstruction remains the dominant choice among patients,while autologous reconstruction was associated with higher aesthetic *** multi-center investigation based on the findings o

关键词： breast cancer mastectomy breast reconstruction questionnaire survey patient satisfaction

breast reconstruction: Does It Worth to Start If the Patient Is Not Sure to Take All the Process Along?

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Journal of Biosciences and Medicines 2022年第8期10卷 201-209页

作者： Jesús Ricardo García-Corral José Martínez-Lopez Rodrigo Davila-Diaz Blanca Arambula-Sanchez Marco Cuervo-Vergara Fernando Barbosa-Villarreal Daniel De Luna Ana Priscila Campollo Lopez Fernando Isaac Recio Espana Alfredo Chama Naranjo Jaime García Alejandro Costa David Flores-Soto Selina Marioni-Manriquez Patricia Lopez-Medellin Erika Barlandas-Quintana Edgar Guillen-Martinez Steve Rodriguez-Alanis Cuahutemoc Marquez Departamento de Cirugía Plástica y Reconstructiva Hospital Central Sur de Alta Especialidad PEMEX Mexico City Mexico

Introduction: breast cancer is the most common cancer in women worldwide, representing a major public health problem. There is still little information comparing the satisfaction of the patients who finished their process against the ones who start it but did not finish it. The aim of our retrospective study was to analyze the results in terms of satisfaction after one year of undergoing to complete breast reconstruction (CBR) vs incomplete breast reconstruction (IBR). Materials and Methods: Retrospective study of patients that underwent breast reconstruction (BR) surgery after mastectomy for breast cancer treatment. Performed at Hospital Central Sur de Alta Especialidad PEMEX in Mexico City, including patients from January 1, 2015 to January 01, 2020. Demographic baseline variables were included. breast-Q satisfaction questionnaires one year after the last reconstructive procedure were analyzed. Results: A total of 44 patients fulfilled the inclusion criteria. Of these 44 patients, 11 were included in the IBR group, and 33 patients in the CBR group. There were no statistically significant differences between the two groups in terms of age (IBR 56.09 vs CBR 53.06 years, p = 0.321);BMI (IBR 27.94 vs CBR 26.40, p = 0.253), time from mastectomy to first reconstructive procedure (IBR 22.8 vs CBR 31 months, p = 0.957), history of chemotherapy (IBR 27.3% vs CBR 33.3%, p = 0.709) and radiotherapy (IBR 54.5% vs CBR 42.4%, p = 0.484), additionally type of reconstruction, affected side or complication rate were not significantly different. Regarding postoperative satisfaction, only the second module of satisfaction with breasts displayed statistically significant differences, with a higher score in the CBR group (46.27 vs 52.27, p = 0.019). Other items explored didn’t show significant differences. Discussion: The data reported in this study suggest that regardless of whether the last stage of a BR is reached, the results in these settings can be very similar in terms of psych

关键词： breast-Q breast reconstruction Satisfaction Index Quality of Life breast Cancer Patient’s Decision Making

Postmastectomy radiotherapy in breast reconstruction:Current controversies and trends

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Cancer Innovation 2024年第1期3卷 113-123页

作者： Honghong Zhang Dandan Song Liangxi Xie Ning Zhan Wenjia Xie Jianming Zhang Department of Radiation Oncology Xiang'an Hospital of Xiamen UniversityCancer Research CenterSchool of MedicineXiamen UniversityXiang'anXiamenFujianChina Fujian Provincial Key Laboratory of Intelligent Identification and Control of Complex Dynamic System Quanzhou Institute of Equipment ManufacturingHaixi InstitutesChinese Academy of SciencesQuanzhouFujianChina

breast cancer is the most common cancer among women *** radiotherapy(PMRT)is an essential component of combined therapy for early-stage,high-risk breast *** reconstruction(BR)is often considered for patients with breast cancer who have undergone *** has been a considerable amount of discussion about the optimal approach to combining PMRT with BR in the treatment of breast *** may increase the risk of complications and prevent good aesthetic results after BR,while BR may increase the complexity of PMRT and the radiation dose to surrounding normal *** purpose of this review is to give a broad overview and summary of the current controversies and trends in PMRT and BR in the context of the most recent literature available.

关键词： breast reconstruction postmastectomy radiotherapy radiotherapy techniques

A systematic review on embodiment and breast reconstruction:a patient-centered framework for evolving breast outcome measures

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Plastic and Aesthetic Research 2023年第1期10卷 783-796页

作者： Madeline G.Chin Sahand C.Eftekari Steven P.Moura D’Andrea T.Donnelly Ellen C.Shaffrey Lucas Sears Aaron M.Dingle Division of Plastic Surgery The Warren Alpert Medical School of Brown UniversityProvidenceRI 02903USA Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthMadisonWI 53705USA

Embodiment describes the sense of one’s own body,encompassing dimensions of being,having,and using a *** breast reconstruction,embodiment can be understood as how effectively the reconstructed breast replaces the patient’s missing *** there has been increasing attention in recent decades on understanding and measuring embodiment in the prosthetic limb,there is limited literature applying embodiment to the context of breast *** posit that the literature on prosthetic embodiment can be applied to evolving discussions on breast reconstruction outcomes and patient *** breast reconstruction techniques continue to evolve,such as advances in nerve coaptation and reinnervation of the breasts,the concept of embodiment may help broaden the scope of how patient outcomes can be more holistically *** systematic review examines existing literature on embodiment after breast reconstruction,summarizes embodiment and its subcomponents,and discusses how embodiment can be a helpful framework for the future of breast reconstruction outcome measures.

关键词： Embodiment breast reconstruction prosthetic embodiment

Pedicled or Free Flap from Contralateral breast for Autologous breast reconstruction

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Chinese Journal of Plastic and Reconstructive Surgery 2020年第2期2卷 103-106页

作者： Jinguang HE Tao WANG Hua XU Yi ZHANG Ying LIU Jiasheng DONG Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiaotong University School of Medicine

Background Through precise understanding of the vascular anatomy of the breast,the lower segment of the breast could be harvested as a pedicled or free flap for contralateral breast *** presentation In case 1,based on the 4th internal thoracic artery perforator,the pedicled flap from the breast was transferred to the contralateral side for immediate breast *** case 2,with the thoracoacromial vascular pedicle,the free flap from the healthy breast was harvested for delayed breast reconstruction on the contralateral *** Both flaps survived well postoperatively.A certain degree of asymmetry was observed in both cases,but the patients were satisfied with the overall *** the end of follow-up,no tumor recurred in either *** In patients with a large healthy breast,the lower segment could be harvested as a pedicled or free flap for contralateral breast reconstruction.

关键词： breast reconstruction Contralateral lower breast Pedicled Free

Progress in Implant-Based breast reconstruction:What Do We Know?

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第2期3卷 103-108页

作者： Xueqing HU Cheng HUANG Department of Plastic and Reconstructive Surgery Second Affiliated HospitalZhejiang University School of MedicineHangzhou Zhejiang 310009China

breast cancer is the most common malignancy and the most frequently diagnosed cancer in women *** China,the incidence rate of breast cancer among women has been showing an upward trend and is higher in urban *** of clinical research have made considerable progress,which is attributable to improved mastectomy and maintenance of a well-perfused skin flap after *** in-depth insight into the nature of breast cancer will contribute to reduced overall mortality and prolonged *** China,there is an increasing awareness of the importance of breast reconstruction in improving quality of life(QoL)and life *** has been progress in breast reconstruction surgical procedures due to demand from *** should be aware that breast reconstruction is not only a medical problem but also a surgical *** the following sections,we present the epitome of advances in implant-based breast reconstruction.

关键词： breast reconstruction Implant Acellular dermal matrix Expander

A network data-based survey and analysis of attention towards breast reconstruction after breast cancer surgery in Chinese and American populations

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第3期3卷 129-135页

作者： Songxue Guo Xueqing Hu Zheren Shao Hui Wang Quan Fang Nan Li Department of Plastic Surgery Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009ZhejiangChina

Background:breast reconstruction is an effective technique to rebuild the appearance of the breasts in patients after mastectomy and improves the *** current study aimed to compare and analyze willingness for breast reconstruction after breast cancer between populations in China and the United States,from the perspective of social concern,using big data *** also aimed to explore factors affecting surgical selection and to identify methods that can improve social cognition and acceptance of breast ***:Using Baidu and Google,two representative Internet search engines in China and the United States as research tools,and using big data search volume as the benchmark,we compared and analyzed breast reconstruction willingness and attention characteristics between Chinese and American people,based on search heat,geographical distribution,age and sex,keyword distribution,ethnic group,and social development ***:In both the long-term and short-term,Chinese people paid more attention towards searching about breast cancer,but less attention to breast reconstruction after breast cancer ***,in both the short-term and long-term,people from the United States paid more attention towards breast cancer and breast reconstruction with the help of the Internet,showing a synchronous change *** was a large regional difference in the search volume for breast cancer among the Chinese population,while no significant regional differences were noted in the search volume for breast cancer in the United ***,a large regional difference was observed in the search volume for breast reconstruction between the two countries;people in the coastal and economically developed areas paid more attention to *** people who paid attention to breast reconstruction in China were women aged 20–39 years,while the attention among men was *** keywords were also limited to breast cancer-related ***,between

关键词： breast cancer breast reconstruction China United States Network searching

Natural History of Seroma Following the Immediate Latissimus Dorsi Flap Method of breast reconstruction

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Chinese Medical Journal 2018年第14期131卷 1674-1679页

作者： Wen-Hui Yan Jian-Bo Mang Li-Li Ren Da-Lie Liu Department of Plastic Surgery Zhujiang Hospital Southern Medical University/The Second School of Clinical Medicine Southern Medical University Guangzhou Guangdong 510280 China Department of breast Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer hospital & Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen Guangdong 518116 China Department of breast Surgery Shenzhen People's Hospital The Second Clinical Medical College of Jinan University Shenzhen Guangdong 518020 China Cytotherapy Laboratory Shenzhen People's Hospital The Second Clinical Medical College of Jinan University Shenzhen Guangdong 518020 China

Background： The latissimus dorsi （LD） flap procedure remains a popular and useful breast reconstrtlction tool in China and Western countries, and donor site seroma formation is the main complication. This study was conducted in Chinese patients to determine whether stable cases of seromas would resolve without treatment. Methods： A retrospective review of 45 consecutive cases of immediate breast reconstruction with LD flap from April 2012 to February 2017 was conducted. The scope of the seroma was demarcated with a marker pen, and cases that remained stable over time （i.e. the size of the seroma did not increase） were observed without treatment. The measured outcomes included the incidence ofseromas, the volume and duration of postoperative wound drainage, and other demographic characteristics. Results： Twenty-four patients （53.3%） developed a seroma at the donor site. Of these, 21 patients （87.5%） did not require treatment, and the seroma resolved over time. The mean duration of a sustained serol-na was 6.8 ± 1.4 weeks （range： 4-9 weeks）. Conclusions： This study observed the scope and progression of the seromas and found that seromas at the LD donor sites resolved over time without treatnlent.

关键词： Autologous breast reconstruction breast reconstruction Latissimus Dorsi Myocutaneous Flap Observation: Seroma