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breast-conserving therapy and modified radical mastectomy for primary breast carcinoma:a matched comparative study

Chinese Journal of Cancer Research 2015年第6期27卷 545-552页

作者： Lize Wang Tao Ouyang Tianfeng Wang Yuntao Xie Zhaoqing Fan Benyao Lin Jinfeng Li Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Breast Cancer Center Peking University Cancer Hospital & Institute

Background- To compare two types of therapy for primary breast carcinoma, breast-conserving therapy （BCT） and modified radical mastectomy （MRM）, in a matched cohort study. Methods： A series of 1,746 patients with primary breast cancer treated with BCT or MRM in a single Chinese institute between January 2000 and February 2009 were analyzed retrospectively to compare their outcomes with respect to the incidence of local recurrence （LR）, distant metastasis, and survival. The patients were matched with regard to age at diagnosis, spreading to axillary lymph nodes, hormone receptor status, the use of neoadjuvant chemotherapy and maximal tumor diameter. The match ratio was 1：1, and each arm included 873 patients. Results： The median follow-up period was 71 months. The 6-year disease-free survival （DFS） and 6-year distant disease-free survival （DDFS） rates differed significantly between two groups. The 6-year local recurrence-free survival （LRFS） rates were 98.2% [95% confidence interval （CI）： 0.973-0.989] in the BCT group and 98.7% （95% CI： 0.980-0.994） in the MRM group （P=0.182）, respectively. DFS rates in BCT and MRM groups were 91.3% （95% CI： 0.894-0.932） and 86.3% （95% CI： 0.840-0.886）（P〈0.001）, respectively, whereas the DDFS rates in BCT and MRM groups were 93.6% （95% CI： 0.922-0.950） and 87.7% （95% CI： 0.854-0.900）（P〈0.001）, respectively. Conclusions： BCT in eligible patients is as effective as MRM with respect to local tumor control, DFS and DDFS, and may result in a better outcome than MRM in Chinese primary breast cancer patients.

关键词： breast carcinoma breast-conserving therapy (BCT) mastectomy recurrence survival

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Migration of the localization wire to the back in patient with nonpalpable breast carcinoma: A case report

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World Journal of Clinical Cases 2021年第26期9卷 7863-7869页

作者： Young Jin Choi Department of Surgery Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea

BACKGROUND Due to the increasing number of diagnosed nonpalpable breast cancer cases,wire localization has been commonly performed for surgical guidance to remove nonpalpable breast *** report presents a rare case of localized wire migration to a subcutaneous lesion of the upper back in a breast cancer patient undergoing breast-conserving *** SUMMARY A 48-year-old female was scheduled for breast-conserving surgery for left breast *** guided wire localization was performed intraoperatively by surgeon to localize the nonpalpable breast *** axilla sentinel lymph node biopsy,we realized that the wire was not *** wire was not found in the operation field,including the breast and ***-conserving surgery was performed after wire *** chest posteroanterior view revealed that the wire was located on the level of midaxillary *** days after the operation,a serial simple X-ray revealed that the wire was located on the subcutaneous lesion of the *** wire tip was palpable under the skin of the upper back,and the wire was removed under local *** Hooked wire misplacement can lead to fatal *** must consider the possibility of wire migration during breast cancer surgery.

关键词： breast carcinoma Hooked wire Migration Nonpalpable breast lesion Wire localization Case report

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Retinoic acid affects basic cellular processes and SOX2 and SOX18 expression in breast carcinoma cells

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BIOCELL 2021年第5期45卷 1355-1367页

作者： ISIDORA PETROVIC MILENA MILIVOJEVIC ANA ARSENIJEVIC ANDRIJANA LAZIC NATASA KOVACEVIC GRUJICIC MARIJA SCHWIRTLICH JELENA POPOVIC MILENA STEVANOVIC Institute of Molecular Genetics and Genetic Engineering University of BelgradeBelgradeSerbia Institute of Cell Biology School of Biological SciencesThe University of EdinburghEdinburghUK Department of Radiation Oncology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Faculty of Biology University of BelgradeBelgradeSerbia Serbian Academy of Sciences and Arts BelgradeSerbia

Genetic and molecular heterogeneity,together with intrinsic and acquired resistance to therapy,represent the major obstacles to the successful treatment of different types of breast *** evidence demonstrates that SOX transcription factors in breast carcinomas could act both as oncogenes and tumor suppressors and have been associated with tumor stage and grade,poor prognosis,and therapy *** SOX2 and SOX18 overexpression has been correlated with poor prognosis in breast carcinomas,and these genes are recognized as potential antitumor *** aim was to evaluate the effect of retinoic acid(RA),a well-known cyto-differentiating agent,on breast carcinoma cells in vitro and to investigate the potential of RA treatment to modify the expression of SOX2 and SOX18 *** applying various experimental approaches,we evaluated the effect of RA on basic cellular processes in SK-BR-3 and MCF7 breast carcinoma cell *** have shown that RA inhibits cell growth,reduces the number of Ki-67 positive cells,and causes cell-cycle *** effect was more prominent in SK-BR-3 cell line that lacks SOX2 expression,including a higher decrease in cell viability,reduction in colony formation,and significant remodeling of cellular *** have shown that RA treatment led to the downregulation of SOX2 expression in MCF7 cells and to the reduction of SOX18 expression in both cell *** functional analysis,we showed that the anti-proliferative effect of RA in both cell lines was not based on the activity of stemness marker SOX2,pointing to a SOX2-independent mechanism of *** ability of RA to reduce SOX2/SOX18 expression raises the possibility that these genes can be used as biomarkers to distinguish RA-responders from ***,our study shows that the response of breast carcinoma cell lines to RA treatment may vary,highlighting that the development of RA-based therapy should consider differences in breast carcinoma subtypes.

关键词： breast carcinoma Anti-proliferative activity Transcription factors MCF7 cell line SK-BR-3 cell line

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Invasive breast carcinoma with osteoclast-like stromal giant cells:A case report

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World Journal of Clinical Cases 2023年第7期11卷 1521-1527页

作者： Yi-Jie Wang Chien-Peng Huang Zhi-Jie Hong Guo-Shiou Liao Jyh-Cherng Yu Department of Surgery Tri Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Traumatology Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of General Surgery Department of SurgeryTri Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Invasive breast carcinoma with osteoclast-like stromal giant cells(OGCs) is an extremely rare morphology of breast *** the best of our knowledge,the most recent case report describing this rare pathology was published six years *** mechanism controlling the development of this unique histological formation is still ***,the prognosis of patients with OGC involvement is also *** SUMMARY We report the case of a 48-year-old woman,who presented to the outpatient department with a palpable,growing,painless mass in her left breast for about one *** and mammography revealed a 26.5 mm ×18.8 mm asymmetric,lobular mass with circumscribed margin and the breast Imaging Reporting and Data System was category ***-guided aspiration biopsy revealed invasive ductal *** patient underwent breast conserving surgery and was diagnosed with invasive breast carcinoma with OGCs,grade Ⅱ,with intermediate grade of ductal carcinoma in situ(ER:80%,3+,PR:80%,3+,HER-2:negative,Ki 67:30%).Adjuvant chemotherapy and post-operation radiotherapy were initiated *** As a rare morphology of breast cancer,breast carcinoma with OGC occurs most often in relatively young women,has less lymph node involvement,and its occurrence is not racedependent.

关键词： breast carcinoma Osteoclast stromal giant cell Pathology Histochemical stains Prognosis Case report

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EXPRESSION AND SIGNIFICANCE OF ERK PROTEIN IN HUMAN breast carcinoma

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Chinese Journal of Cancer Research 2004年第4期16卷 269-273页

作者：张秀梅李柏林宋敏宋继谒 Department of Pathology The Third People’s Hospital of DalianDalian 116033 Department of Chemistry China Medical UniversityShenyang 110001 Department of Pathology College of Basic Medical Science China Medical UniversityShenyang 110001

Objective: To investigate the expression of ERK and p-ERK protein in human breast cancer and their corresponding tissue, to assess the significance of ERK signal pathway in tumorigenesis and progression of breast carcinoma. Methods: 40 breast cancer cases were used in S-P immunohistochemistry technique and Western Blot study. Results: The expression of ERK1, ERK2, and p- ERK protein levels increased remarkably in breast cancer tissues in comparison to normal tissues (Pbreast cancer. Protein levels of ERK and p-ERK were higher in stage III patients than in stage I and stage II patients (Pbreast cancer, but not correlated with histopathological type and status of ER and PR of breast cancer. Expression of ERK1, and ERK2, protein showed a positive linear correlation. Conclusion: ERK signal transduction pathway is a key factor during human breast tumorigenesis and breast cancer progression.

关键词： Extracellular signal-related kinase breast carcinoma Phosphorylation Immunohistochemistry Metastasis

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EXPRESSION AND CLINICAL SIGNIFICANCE OF p73A IN breast carcinoma TISSUES

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Chinese Journal of Cancer Research 2005年第1期17卷 75-78页

作者：周鑫孙治君 Department of General Surgery The First Affiliated Hospital Chongqing University of Medical Sciences Chongqing 400016

Objective: To study the expression and clinical significance of p73α in breast carcinomas. Methods: The expression of p73α was detected by immunohistochemistry in 41 breast carcinoma tissues, 13 benign breast tumor tissues and 8 normal tissues and 8 normal breast tissues, respectively. Results: The positive expression of p73α was found in 20/41 (48.8%) of breast carcinoma tissues, 1/13 (7.7%) of benign breast tumor tissues. The positive expression rate of p73α in breast carcinoma tissues was significant1y higher than that in benign breast tumor tissues and normal breast tissues (Pbreast carcinoma tissues compared with benign breast tumor tissues and normal breast tissues (Pcarcinoma was found (Pbreast carcinoma tissues, which may be implicated in the tumorigenesis of breast carcinoma as a molecular alteration.

关键词： breast carcinoma p73α p53 protein p21 protein

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RELATIONSHIP BETWEEN EXPRESSIONS OF P38 PROTEIN IN HUMAN breast carcinoma AND LYMPH NODES METASTASIS

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Chinese Journal of Cancer Research 2006年第2期18卷 94-98页

作者：李柏林李凤韩艳春宋敏宋继谒 Department of Chemistry College of Basic Medical Sciences China Medical University Shenyang 110001 Department of Pathology College of Basic Medical Sciences China Medical University Shenyang 110001

Objective： To detect the change of p38 protein expression and investigate the relationship of p38 and lymph nodes metastasis in human breast carcinomas. Methods： Sixty breast cancer cases were checked by S-P immunohistochemistry technique and 30 breast cancer cases were examined by Western Blot. Results： Immunohistochemical results showed that p38 protein was observed in breast cancer and normal cytoplasm. P-p38 was positive in nucleus in breast cancer. P38 protein expressed positively in 29 out of 38 patients who had lymph nodes metastasis （positive rate 76.3%） and in 9 out of 22 patients who had no lymph nodes metastasis （positive rate 40.9%）. There was a significant difference between these two groups （P〈0.01）. The positive rate of p-p38 in patients who had lymph nodes metastasis was 68.4%, and the positive rate in patients who had no metastasis was 36.4%, and there was a significant difference between these two groups （P〈0.05）. The result of western blot showed that the protein contents of p38 and p-p38 in patients with metastasis was higher than those in patients without metastasis （P〈0.05）. P38 and p-p38 protein expressions had relation with clinical pathological grades in breast cancer, higher in grade Ⅲ than in grade Ⅰ, Ⅱ （P〈0.05）, while had no relation with patients＇ age and tumor size （P〉0.05）. Conclusion： p38 and p-p38 protein expressions had relationship with lymph nodes metastasis and the levels of p38 and p-p38 protein expression in groups with lymph nodes metastasis were higher than in groups without lymph nodes metastasis. P38 and p-p38 protein expressions had relationship with clinical grades and had no relationship with patients＇ age and tumor size.

关键词： p38MAPK breast carcinoma Phosphorylation Metastasis

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CORRELATION BETWEEN LAMININ AND CATHEPSIN D EXPRESSIONS IN breast carcinoma

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Chinese Journal of Cancer Research 2006年第4期18卷 261-264页

作者：陈峰陈伟红郑建明黄玲 Department of Pathology Renji Hospital Chongming Branch Shanghai Jiaotong University Department of Pathology Changhai Hospital

Objective： Laminin is a major glycoprotein component of basement membrance which is an important barrier to tumor cells which must be breeched before metastatic spread can occur. Proteolytic enzymes play an important role in mediating the passage of cancer cells through the basement membrane （BM） and extracellular matrix. We compared the patterns of laminin and cathepsin D （CD） expressions in a range of benign and malignant breast lesions to better understand the process of tumor progression. Methods： One hundred and sixty-two cases of breast samples comprising 18 fibroadeomas, 22 cases of fibrocystic disease, 96 cases of invasive ductal carcinoma and 26 carcinomas with intraductal components were evaluated for laminin and cathepsin D expressions by immunohistocbemical staining. Results： The prevalence of CD positivity in both neoplastic and stromal cell components were significantly higher in higher histological grade tumors compared to lower grades （P〈0.001）. Various severity of BM disruption correlated with histological grade of the carcinomas （P〈0.001）. There was a negative correlation between the laminin expression and CD presence. Conclusion： In the process of cancer cell invasion and metastasis, the basement membrane is disrupted by proteinase secreted by cancer cells, especially by stroma cells of cancer.

关键词： breast carcinoma Laminin Cathepsin D Immunohsitochemistry

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CLINICAL SIGNIFICANCE OF P-GLYCOPROTEIN EXPRESSION IN METASTATIC breast carcinoma

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Chinese Journal of Cancer Research 2005年第1期17卷 71-74页

作者：李恩孝何仲琴吴媛何静李毅 Department of Medical Oncology the First Hospital of Xi’an Jiaotong University Xi'an 710061 Department of Oncology Baoji Traditional Chinese Medicine Hospital Baoji 721000

Objectives: To evaluate the expression of P-glycoprotein (P-gp) and it's effect on chemotherapy response in metastatic breast carcinoma. Methods: 46 postoperative patients with metastatic breast carcinoma were enrolled. P-gp expression was detected by SABC immunohistochemical method. These patients were treated with combined chemotherapy of cyclophosphamide, pirarubicin and 5-fluorouracil for at least two cycles. The relationship between P-gp expression and chemotherapeutic response was analyzed. Results: The positive rate of P-gp expression was 56.5%, the P-gp expression in the patients with lung or liver metastasis was higher than that in patients with skin or lymph node metastasis (P=0.049). The overall response rate was 58.1% in 43 patients; the response rate (89.5%) of the P-gp negative group was higher than that (30.0%) of the P-gp positive group (Pbreast carcinoma had higher P-gp expression and these patients should be treated with non-MDR drugs chemotherapy.

关键词： breast carcinoma P-glycoprotein Chemotherapy Prognosis

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An elderly female patient with ROS1 rearrangement primary lung adenocarcinoma and breast carcinoma:a rare case report and review of the literature

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Precision Clinical Medicine 2019年第3期2卷 197-203页

作者： Xiaojuan Yang Diyuan Qin Yu Zhang Xue Li Ning Liu Ying Zhou Ming Feng Yongsheng Wang Department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityNo.37 Guo Xue XiangChengdu 610041China State Key Laboratory of Biotherapy Sichuan UniversityNo.17Section 3Renmin South RoadChengdu 610041China Department of Pathology West China HospitalSichuan UniversityNo.37 Guo Xue XiangChengdu 610041China

We report the case of a 90-year-old female patient who was suffering from c-ros oncogene 1(ros-1)rearrangement adenocarcinoma and breast *** about 14 months of a reduced dose of crizotinib treatment,she had a stable disease according to the Response Evaluation Criteria in Solid Tumors version 1.1(RECIST 1.1).This patient’s case demonstrates that ros-1 rearrangements are not limited to patients of young *** addition,this case indicates that crizotinib,as second-line,or even first-line,treatment may be effective and manageable in elderly ***,for elderly patients carrying a ros1 fusion,a reduced dose of crizotinib may be efficacious rather than a resistance *** on our findings,we recommend that elderly patients with advanced lung adenocarcinoma should be considered for inclusion in molecular screening for ros-1 translocation,especially for never-smokers negative for epidermal growth factor receptor(egfr)mutation and the fusion between echinoderm microtubule associated protein-like 4(EML4)and anaplastic lymphoma kinase(ALK).This deserves attention because the population is aging,with increasing incidence and morbidity of multiple primary malignant *** of breast nodules at the onset is one of the limitations of our case,as combination of primary lung cancer with breast cancer is *** all,use of antiestrogens before and after the diagnosis of non-small-cell lung cancer is related to a reduced risk of lung cancer ***,careful attention should always be paid to these cases.

关键词： elderly patients lung cancer breast carcinoma ros1 rearrangement crizotinib

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