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Anti-breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice

Asian Pacific Journal of Tropical Biomedicine 2015年第12期5卷 1018-1026页

作者： Latifah Saiful Yazan Yong Sze Ong Nur Elena Zaaba Razana Mohd Ali Jhi Biau Foo Yin Sim Tor Laboratory of Molecular Biomedicine Institute of Bioscience Universiti Putra Malaysia Department of Biomedical Science Faculty of Medicine and Health Sciences Universiti Putra Malaysia Department of Pathology Faculty of Medicine and Health Sciences Universiti Putra Malaysia

Objective:To determine the anti-breast cancer activities and the safety oral consumption of Dillenia suffruticosa root aqueous extract(DRAE)in BALB/c ***:In the anti-breast cancer study,female BALB/c mice were divided into five groups(n=12),which were(1)positive control(with breast cancer,untreated),(2)negative control(without breast cancer,untreated)and other three groups of mice with breast cancer treated with 1 000,500 and 250 mg/kg of DRAE,respectively,by oral gavage for 28 *** mice except from the negative control group were injected into the mammary fat pad with 4T1 cells(1×1054T1 cells/0.1 m L of phosphate buffer solution).DRAE was administered orally on Day 11 after the tumor has ***:The tumor volume of the 1 000 mg/kg of DRAE group reduced significantly compared to the positive control while treatment with 500 mg/kg of DRAE had significantly inhibited metastasis to the *** the acute toxicity study,treatment with up to5 000 mg/kg of DRAE was not toxic to the animals,indicating its safety when a large amount of this plant extract was *** on the sub-acute toxicity study,treatment of the highest dose of DRAE(1 000 mg/kg)had mild liver toxicity indicated by mild focal ***:DRAE possesses anti-breast cancer properties but at the same time it shows mild toxicity to the *** non observable adverse effect dose for DRAE is500 mg/kg.

关键词： Dillenia suffruticosa 4T1 Tumor-bearing mice breas

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