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Protective Effect of Oral Steroid Premedication: Adverse reactions to Nonionic Iodine Contrast Media for Computed Tomography

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Open Journal of Radiology 2022年第3期12卷 102-112页

作者： Norikazu Koori Akiko Maeda Mayumi Yasui Hiroki Kamekawa Yusuke Yoshida Akari Noda Yuta Shiraki Kazuya Yokoi Yudai Suzuki Kazuma Kurata Hiroko Nishikawa School of Health Sciences Ibaraki Prefectural University of Health Sciences Ibaraki Japan Division of Health Sciences Graduate School of Medical Sciences Kanazawa University Kanazawa Japan Department of Radiology Komaki City Hospital Komaki Japan Department of Neurology Komaki City Hospital Komaki Japan

This study aimed to investigate the protective effect of oral steroid premedication in terms of adverse reactions to non-ionic contrast media. We investigated the incidence of adverse reactions among patients who underwent contrast-enhanced computed tomography. Patients in the premedication group took 30 mg of prednisolone orally the night before and on the morning of the scheduled computed tomography. Sixty-five patients received the same contrast media. Among them, 56 took prednisolone orally prior to the procedure (premedication without change of contrast media group) and nine without premedication (no premedication and no change of contrast media group). In total, 379 patients received different contrast media. Among them, 340 took prednisolone orally (premedication with change of contrast media group), while 39 did not take the premedication (no premedication with change of contrast media group). The adverse reaction rates in the premedication with change of contrast media and no premedication with change of contrast media groups were 1.8% (6/340 cases) and 2.6% (1/39 cases) (P = 0.54), respectively. The incidence of adverse reaction after the administration of non-ionic iodinated contrast media did not differ significantly based on whether an oral steroid was administered prior to compute tomography. Our evaluation is limited due to the small sample size of the contrast media-changed group. However, even if premedication with steroids is effective, it may only result in an adverse reaction reduction rate of ≤3%.

关键词： Iodine Contrast Media Oral Steroid Premedication breakthrough reaction Prednisolone Adverse reactions

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