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Wide‑field swept‑source OCT angiography of the periarterial capillary‑free zone before and after anti‑VEGF therapy for branch retinal vein occlusion

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Eye and Vision 2024年第2期10卷 31-40页

作者： Wenyi Tang Wei Liu Jingli Guo Lili Zhang Gezhi Xu Keyan Wang Qing Chang Department of Ophthalmology Eye and ENT Hospital of Fudan University83 Fenyang RoadShanghai 200031China Shanghai Key Laboratory of Visual Impairment and Restoration Fudan UniversityShanghaiChina NHC Key Laboratory of Myopia(Fudan University) Laboratory of MyopiaChinese Academy of Medical SciencesShanghaiChina

Background:The aim of the study was to investigate the changes in the periarterial capillary-free zone(paCFZ)after anti-vascular endothelial growth factor(VEGF)therapy in patients with branch retinal vein occlusion(BRVO)by widefield swept-source optical coherence tomography angiography(SS-OCTA)and assess their associations with clinical ***:In this retrospective observational study of 54 treatment-naive BRVO patients with macular edema,we reviewed the findings of 12×12 mm^(2)SS-OCTA at baseline,3,6,and 12 months after intravitreal ranibizumab *** paCFZ and major retinal artery areas were measured on SS-OCTA *** paCFZ area to artery area(P/A)ratio was ***:The paCFZ areas and P/A ratios of first-and second-order arteries were significantly greater in BRVO eyes than in contralateral eyes(all Pretinal thickness,and their improvements at 3,6,and 12 months(all P<0.05).Baseline BCVA and P/A ratios of first-and second-order arteries were independently associated with the final BCVA in multivariate linear ***:Wide-field SS-OCTA shows that anti-VEGF therapy can lead to a significant improvement in the paCFZ parameters in *** baseline P/A ratios on SS-OCTA tend to predict better visual outcomes at 12 months after anti-VEGF therapy.

关键词： Swept-source optical coherence tomography angiography branch retinal vein occlusion Periarterial capillary free zone Anti-VEGF treatment Prognosis

Comparison of intravitreal injection of conbercept and triamcinolone acetonide for macular edema secondary to branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2020年第11期13卷 1765-1772页

作者： Miao Zhao Ce Zhang Xi-Mei Chen Yan Teng Tian-Wei Shi Fei Liu Department of Ophthalmology the Second Hospital of Dalian Medical UniversityDalian 116027Liaoning ProvinceChina Drug Clinical Trials Institution the Second Hospital of Dalian Medical UniversityDalian 116027Liaoning ProvinceChina

AIM:To compare the safety and efficacy of the intravitreal injection of conbercept(IVC)and triamcinolone acetonide(IVTA)for macular edema(ME)secondary to branch retinal vein occlusion(BRVO).METHODS:A prospective,randomized clinical *** with ME secondary to BRVO were randomly assigned to either IVC group or IVTA group at a ratio of 2:1 and a 12-month follow-up was *** efficacy outcome measures included the mean changes and differences in best corrected visual acuity(BCVA)and the central retinal thickness(CRT).The safety profiles and the mean retreatment intervals were also ***:There was no statistically significant difference of baseline between the two groups(IVC group,n=36;IVTA group,n=17).At 12mof the BCVA letters improved by 27.31±18.36 in the IVC group,and 13.53±11.37 in the IVTA group(P=0.0004).CRT reduction was 253.33±163.69 and 150.24±134.32 pm,respectively(P=0.0034).The mean BCVA in the IVC group was superior to that of the IVTA group for months 6-12(P<0.01).The mean CRT at 9 and 12mo were thinner in the IVC group compared to the IVTA group(P<0.01).The mean retreatment interval in the IVC group was longer than that in the IVTA group(97.40±36.27d vs 68.71±36.38d,P=0.0030).One eye in the IVC group and seven eyes in the IVTA group developed elevated intraocular pressure(IOP;P=0.0012).The proportion of eyes with cataract new-onset or progression were 19.44%in the IVC group and 64.71%in the IVTA group(P=0.0012).CONCLUSION:IVC could maintain or improve BCVA and reduce CRT for a longer time and have longer retreatment interval than *** addition,patients treated with IVTA are more susceptible to IOP elevation and cataract progression.

关键词： conbercept triamcinolone acetonide branch retinal vein occlusion macular edema

Efficacy of intravitreal conbercept injection on short-and long-term macular edema in branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 489-494页

作者： Jing-Yi Bai Wen-Ying Wang Zhi-Zhi Dou Bo-Chao Geng Xiao-Yan Xu Yuan-Zhang Zhu Shan-Yao Zhao Min Liu Shao-You Jia Wen-Juan Luo Department of Ophthalmology Qingdao University Affiliated HospitalQingdao 266003Shandong ProvinceChina The People’s Hospital of Zoucheng City Jining 272000Shandong ProvinceChina

AIM: To observe the best-corrected visual acuity(BCVA) and central foveal thickness(CFT) repeatedly after the intravitreal injection of conbercept(IVC) for treating cystoid macular edema(CME) in branch retinal vein occlusion(BRVO) and explore the relationship between the duration of CME and visual ***: Subgroup analysis was performed to compare short-term(within 90 d of CME onset) and longterm(over 90 d of CME onset) macular edema in *** an initial IVC, a pro re nata(PRN) strategy was performed according to the recurrence of CFT or decrease of *** of variance using repeated measurements, statistical analysis following indicators including BCVA and CFT collected at baseline and 1, 3, and 6 mo after ***: Among the 60 cases included in this retrospective study, 36 were short-term CME, and 24 were long-term *** were statistical significances between and within groups of the BCVAs at different time points(P<0.001).The interaction was found between group and time(P=0.006), indicating the difference in the speed of BCVA improvement between *** particular, the improvement speed of BCVA in the short-term CME group was faster than that in the long-term CME *** were significant differences between and with groups of the CFT at different time points(P<0.001).However, the interaction between group and time in relation to CFT had no significant differences(P=0.59).CONCLUSION: IVC treatment for CME following BRVO is effective and *** duration of CME before treatment is a significant predictor of the visual outcomes of patients with *** improvement of vision might be faster with early IVC treatment than with delayed treatment.

关键词： vascular endothelial growth factor branch retinal vein occlusion conbercept best-corrected visual acuity macular edema

Visual acuity after intravitreal ranibizumab with and without laser therapy in the treatment of macular edema due to branch retinal vein occlusion:a 12-month retrospective analysis

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1565-1570页

作者： Reiko Umeya Koichi Ono Toshimitsu Kasuga Department of Ophthalmology Juntendo Tokyo Koto Geriatric Medical CenterTokyo 136-0075Japan Department of Ophthalmology Juntendo University School of MedicineTokyo 113-8421Japan

AIM:To identify factors contributing to visual improvement after treatment of macular edema(ME)secondary to branch retinal vein occlusion(BRVO),and to assess the interaction between laser therapy and intravitreal ranibizumab(IVR).METHODS:We retrospectively reviewed the medical records of patients who had been treated for BRVO-related ME at our *** were traceable for at least 12 mo,and evaluated factors included age,sex,medical history,smoking history,treatment methods,foveal hemorrhage,and change in visual *** included laser therapy,IVR,sub-Tenon’s capsule injection of triamcinolone(STTA),a combination,or no *** logistic regression analysis and interaction terms were used to assess the clinical efficacy of the treatments,and odds ratios(OR)and 95%confidence intervals(CI)were ***:Seventy-three patients(34 men,39 women;73 eyes)with a mean age of 69.4±12.1 y were *** who underwent IVR monotherapy,laser monotherapy,and STTA+laser had significantly higher best corrected visual acuity at 12 mo compared to baseline(P<0.001,<0.001,and 0.019,respectively).Logistic regression analysis without interaction terms found that IVR was a significant visual acuity recovery factor(adjusted OR:3.89,95%CI:1.25-12.1,P=0.019).Adjusted OR using an interaction model by logistic regression was 16.6(95%CI:2.54-108.47,P=0.003)with IVR treatment,and 8.25(95%CI:1.34-50.57,P=0.023)with laser *** interaction was observed(adjusted OR:0.07,95%CI:0.01-0.75,P=0.029).CONCLUSION:IVR contributes to improvements in visual acuity at 12 mo in ME secondary to *** interaction is observed between laser therapy and IVR treatments.

关键词： interaction ranibizumab laser macular edema branch retinal vein occlusion

Study of retinal vessel oxygen saturation in ischemic and non-ischemic branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 99-107页

作者： Lei-Lei Lin Yan-Min Dong Yao Zong Qi-Shan Zheng Yue Fu Yong-Guang Yuan Xia Huang Garrett Qian Qian-Ying Gao Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat-sen University School of Optometry and Vision Science The University of New South Wales

AIM：To explore how oxygen saturation in retinal blood vessels is altered in ischemic and non-ischemic branch retinal vein occlusion（BRVO）.·METHODS：Fifty BRVO eyes were divided into ischemic（=26）and non-ischemic（=24）groups,based on fundus fluorescein *** individuals（=52 and=48,respectively）were also recruited as controls for the two *** mean oxygen saturations of the occluded vessels and central vessels were measured by oximetry in the BRVO and control groups.·R ESULTS：In the ischemic BRVO group,the occluded arterioles oxygen saturation（Sa O2-A,106.0%±14.3%）,instead of the occluded venule oxygen saturation（Sa O2-V,60.8%±9.4%）,showed increases when compared with those in the same quadrant vessels（Sa O2-A,86.1%±16.5%）in the contralateral eyes（〈0.05）.The oxygen saturations of the central vessels showed similar trends with those of the occluded *** the non-ischemic BRVO group,the occluded and central Sa O2-V and Sa O2-A showed no significant *** both the ischemic and non-ischemic BRVOs,the central Sa O2-A was significantly increased when compared to healthy individuals.·CONCLUSION：Obvious changes in the occluded and central Sa O2-A were found in the ischemic BRVO group,indicating that disorders of oxygen metabolism in the arterioles may participate in the pathogenesis of ischemic BRVO.

关键词： hypoxia ischemia oximetry oxygensaturation branch retinal vein occlusion

Comparison of one and three initial monthly intravitreal ranibizumab injection in patients with macular edema secondary to branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1534-1538页

作者： Alper Halil Bayat Akin Cakir Seyma Gülcenur Ozturan Selim Bolükbasi Burak Erden Mustafa Nuri Elcioglu Departmant of Opthalmology Okmeydani Research&Traning HospitalIstanbul 34384Turkey

AIM： To compare three initial monthly intravitreal ranibizumab（IVR） injections followed by pro re nata（PRN） dosing with one initial monthly IVR injections followed by PRN dosing for macular edema（ME） secondary to branch retinal vein occlusion（BRVO）.METHODS： Forty-two eyes of 42 patients who had IVR injections for BRVO were retrospectively studied. Eighteen eyes received 1 initial IVR injection（1＋PRN group） and 24 eyes received 3 monthly IVR injections（3＋PRN）. At 1, 3, 6 and 12mo; spectral-domain optical coherence tomography（SD-OCT） was performed. Central macular thickness（CMT）, the integrity of the external limiting membrane（ELM）, the presence of subretinal fluid, cyst size, the presence of inner segment/outer segment（IS/OS） defect were ***： At baseline the mean CMT was 521.3±153.2 μm in the 3＋PRN group while it was 438.1±162.4 μm in 1＋PRN group. At the final visit, mean CMT was 278.3±87.8 μm in the 3＋PRN group and 285.2±74.2 μm in the 1＋PRN group（P=0.079）. The changes in CMT over the entire study period were also comparable in both groups（243±160 μm in the 3＋PRN group, and 152.9±175.3 μm in the 1＋PRN group; P=0.090）. At baseline, best-corrected visual acuity（BCVA） was 0.92±0.60 logarithm of the minimal angle of resolution（logMAR） in the 3＋PRN group, while it was 0.72±0.46 logMAR in the 1＋PRN group. Final BCVA was 0.42±0.55 logMAR in the 3＋PRN group and 0.38±0.50 logMAR in the 1＋PRN group（P=0.979）. Additionally, the BCVA changes from baseline to final visit were not significantly different（-0.50±0.45 logMAR in the 3＋PRN group, and-0.33±0.39 logMAR in the 1＋PRN group; P=0.255）.CONCLUSION： No significant differences in the anatomical or functional results are found between 3＋PRN and 1＋PRN regimens in the patients receiving ranibizumab for ME secondary to BRVO. Intact IS/OS and baseline BCVA are good predictor of the visual gain, while baseline CMT is a good predictor of the anatomical gain.

关键词： branch retinal vein occlusion ranibizumab macular edema therapy predictive factors

Choroidal thickness measurements with optical coherence tomography in branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 725-729页

作者： Muge Coban-Karatas Rana Altan-Yaycioglu Burak Ulas Selcuk Sizmaz Handan Canan Cagla Sariturk Department of Ophthalmology Baskent University School of Medicine Department of Ophthalmology Cukurova University School of Medicine Division of Biostatistics Baskent University Adana Clinic and Research Center

AIM： To evaluate central macular thickness（CMT） and mean choroidal thickness（MCT） in eyes with branch retinal vein occlusion（BRVO）, before and after ranibizumab treatment using spectral domain-optical coherence tomography（SD-OCT）.·METHODS： Forty-two patients with unilateral BRVO and macular edema were included in this study. There were 25 men and 17 women. Using SD-OCT, choroidal thickness was measured at 500 μm intervals up to 1500μm temporal and nasal to the fovea. MCT was calculated based on the average of the 7 locations. All the eyes with BRVO were treated with intravitreal ranibizumab（0.5 mg/0.05 m L）. Comparisons between the BRVO and fellow eyes were analyzed using Mann-Whitney U test. Preinjection and post-injection measurements were analyzed using Wilcoxon test and repeated measure analysis.· RESULTS： At baseline, there was a significant difference between the BRVO and fellow eyes in MCT[BRVO eyes 245（165-330） μm, fellow eyes 229（157-327） μm]and CMT [BRVO eyes 463（266-899） μm, fellow eyes 235（148-378） μm（P =0.041, 0.0001, respectively）]. Following treatment, CMT [295（141-558） μm] and MCT [229（157-329） μm] decreased significantly compared to the baseline measurements（P =0.001, 0.006, respectively）.Also BCVA（log MAR） improved significantly（P=0.0001） in the BRVO eyes following treatment. After treatment CMT[BRVO eyes 295（141-558） μm, fellow eyes 234（157-351） μm]and MCT [BRVO eyes 229（157-329） μm, fellow eyes 233（162-286） μm] values did not reveal any significant difference in BRVO eyes and fellow eyes（P=0.051, 0.824,respectively）.· CONCLUSION： In eyes with BRVO, CMT and MCT values are greater than the fellow eyes, and decrease significantly following ranibizumab injection.

关键词： branch retinal vein occlusion choroidal thickness macular edema optical coherence tomography ranibizumab

Optical coherence tomography angiography for macular microvessels in ischemic branch retinal vein occlusion treated with conbercept:predictive factors for the prognosis

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2049-2055页

作者： Li Tang Guang-Li Sun Yue Zhao Ting-Ting Yang Jin Yao Department of Ophthalmology the Affiliated Eye Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

AIM:To evaluate the predicative factors of visual prognosis using optical coherence tomography angiography(OCTA)in ischemic branch retinal vein occlusion(BRVO)patients with macular edema(ME)after anti-vascular endothelial growth factor(VEGF)***:In this retrospective analysis,data from 60 patients(60 eyes)with a definite diagnosis of ischemic BRVO with ME by fundus fluorescein angiography(FFA)were *** eyes with ME according to spectral domain optical coherence tomography(SD-OCT)underwent intravitreal conbercept(IVC)and 3+pro re nata(PRN)*** injection times were *** weeks after injection,fundus laser photocoagulation was performed in the non-perfusion area of the *** patients were followed up once a month for *** bestcorrected visual acuity(BCVA),foveal avascular zone(FAZ),and A-circularity index(AI),at 6mo and the baseline were ***:All patients showed significant improvement in BCVA from 0.82±0.32 to 0.39±0.11 logMAR(P<0.001).The mean central macular thickness(CMT)significantly decreased from 476.22±163.54 to 298.66±109.23μ*** the FAZ area and AI at 6mo were significantly higher than those at the baseline:the FAZ area increased(0.38±0.02 vs 0.39±0.02 mm^(2),P<0.05);the AI increased(1.27±0.02 vs 1.31±0.01,P=0.000).The baseline BCVA showed a significantly positive correlation with the baseline FAZ area,FAZ perimeter(PERIM)and AI,final visual gain(FVG)and injection times,respectively(P<0.001).FVG showed a significantly negative correlation with the FAZ area,PERIM,AI and injection times,but a significantly positive correlation with vessel densities(VDs)300μm area around FAZ(FD-300;P<0.001).Injection times was positively correlated with the baseline FAZ area,and AI,but inversely correlated with the baseline FD-300(P<0.001).However macular ischemia was noted in 5 cases during ***:Using OCTA to observe macular ischemia and quantify parameters can better predict the final visual prognosis of p

关键词： optical coherence tomography angiography branch retinal vein occlusion macular edema foveal avascular zone conbercept

Peripheral retinal non-perfusion and treatment response in branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 858-862页

作者： Kaveh Abri Aghdam Lukas Reznicek Mostafa Soltan Sanjari Carsten Framme Anna Bajor Annemarie Klingenstein Marcus Kernt Florian Seidensticker Department of Ophthalmology University Eye HospitalMedical School of Hannover Carl-Neuberg-Straβe 1Hannover 30625 Germany Department of Ophthalmology Ludwig Maximilians University Mathildenstr. 8 Munich 80336 Germany Eye Research Center Rassoul Akram Hospital lranUniversity of Medical Sciences Sattarkhan-Niayesh StreetTehran 14456-13131 Iran

AIM： To evaluate the association between the size of peripheral retinal non-perfusion and the number of intravitreal ranibizumab injections in patients with treatment-naive branch retinal vein occlusion （BRVO） and macular edema. METHODS： A total of 53 patients with treatment-naive BRVO and macular edema were included. Each patient underwent a full ophthalmologic examination including optical coherence tomography （OCT） imaging and ultra wide-field fluorescein angiography （UWFA）. Monthly intravitreal ranibizumab injections were applied according to the recommendations of the German Ophthalmological Society. Two independent, masked graders quantified the areas of peripheral retinal non-perfusion. RESULTS： Intravitreal injections improved bestcorrected visual acuity （BCVA） significantly from 22.23± 16.33 Early Treatment of Diabetic Retinopathy Study （ETDRS） letters to 36.23 ±15.19 letters （P〈0.001）, and mean central subfield thickness significantly reduced from 387±115 pm to 321±115 μm （P=0.01）. Mean number of intravitreal ranibizumab injections was 3.61±1.56. The size of retinal non-perfusion correlated significantly with the number of intravitreal ranibizumab injections （R= 0.724, P〈0.001）. CONCLUSION： Peripheral retinal non-perfusion in patients with BRVO associates significantly with intravitreal ranibizumab injections in patients with BRVO and macular edema.

关键词： angiography branch retinal vein occlusion non-perfusion retina wide-field