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Mechanisms of phototherapy of Alzheimer’s disease during sleep and wakefulness:the role of the meningeal lymphatics

Frontiers of Optoelectronics 2023年第3期16卷 57-76页

作者： Semyachkina‑Glushkovskaya Oxana Shirokov Alexander Blokhina Inna Fedosov Ivan Terskov Andrey Dubrovsky Alexander Tsoy Maria Elovenko Daria Adushkina Viktoria Evsukova Arina Telnova Valeria Tzven Anna Krupnova Valeria Manzhaeva Maria Dmitrenko Alexander Penzel Thomas Kurths Jürgen Institute of Physics Humboldt UniversityBerlin 12489Germany Department of Biology Saratov State UniversitySaratov 410012Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of SciencesSaratov 410049Russia Charité–Universitätsmedizin Berlin Berlin 10117Germany Department of Complexity Scienc Potsdam Institute for Climate Impact ResearchPotsdam 14473Germany

With the increase in the aging population,the global number of people with Alzheimer’s disease(AD)progressively increased *** situation is aggravated by the fact that there is no the efective pharmacological therapy of ***(PBM)is non-pharmacological approach that has shown very promising results in the therapy of AD in pilot clinical and animal ***,the mechanisms of therapeutic efects of PBM for AD are poorly *** this study on mice,we demonstrate that photodynamic efects of 5-aminolevulenic acid and laser 635 nm cause reduction of network of the meningeal lymphatic vessels(MLVs)leading to suppression of lymphatic removal of beta-amyloid(Aβ)from the right lateral ventricle and the *** the original protocol of PBM under electroencephalographic monitoring of wakefulness and sleep stages in non-anesthetized mice,we discover that the 7-day course of PBM during deep sleep *** provides better restoration of clearance of Aβfrom the ventricular system of the brain and the *** results shed light on the mechanism of PBM and show the stimulating efects of PBM on the brain lymphatic drainage that promotes transport of Aβvia the lymphatic *** efects of PBM on the brain lymphatics in sleeping brain open a new niche in the study of restorative functions of sleep as well as it is an important informative platform for the development of innovative smart sleep technologies for the therapy of AD.

关键词： Alzheimer’s disease Photobiomodulation brain lymphatics Sleep Mechanisms

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