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Insight into Hydrolytic Stability and Tribological Properties of B-N coordination Tung Oil-Based Lubricant Additive in Water

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Journal of Renewable Materials 2023年第3期11卷 1367-1381页

作者： Na Yao Haiyang Ding Mei Li Pengcheng Wang Shouhai Li Lina Xu Xiaohua Yang Institute of Ecological Conservation and Restoration CAFBeijing100091China Institute of Chemical Industry of Forest Products CAF、National Engineering Laboratory for Biomass Chemical Utilization、Key Laboratory of Chemical Engineering of Forest ProductsNational Forestry and Grassland Administration、Key Laboratory of Biomass Energy and MaterialJiangsu Province、Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesNanjing210042China School of Chemical Engineering Nanjing University of Science&TechnologyNanjing210094China

A tung oil-based boron-nitrogen coordination polymer(TWE-BN)was specially designed and synthesized as a highly efficient water-based lubricant additive,which has been beneficial to both energy conservation and conducive to environmental *** hydrolysis stability and tribological properties in water were *** better research the lubricating properties,and thus to understand the interaction between the surface and the lubricating ***,both experimental and theoretical computations based on density functional theory(DFT)were *** addition of TWE-BN reduces the water friction coefficient and wear scar diameter,and the maximum non-seizure load increased from 93 to 726 ***,the anti-corrosion ability on copper was classified as 1b *** stainless-steel surface was analyzed using scanning electron microscopy(SEM)and X-ray photoelectron spectroscopy(XPS).In hydrolytic stability testing,TWE-BN was better than nitrogen-free tung oil-based lubricant additive(TWE-B)and remained non-hydrolyzed for at least 15 days,implying the feasibility of tung oil-based boron-nitrogen coordination as highly effective and hydrolytic stability lubricant additives.

关键词： Tribological properties tung oil borate hydrolytic stability boron-nitrogen coordination

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IL-2-loaded Polypeptide Nanoparticles for Enhanced Anti-cancer Immunotherapy

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Chinese Journal of Polymer Science 2023年第7期41卷 1059-1068页

作者： Xiao-Shuang Wang Zhao-Shi Zheng Meng-Fei Zheng Di Wang Hong-Lei Zhang Zhen-Qian Zhang Zhi-Lin Liu Zhao-Hui Tang Xue-Mei Han No.1 Department of Neurology China-Japan Union Hospital of Jilin UniversityChangchun130033China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China Jilin Biomedical Polymers Engineering Laboratory Changchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education and Key Laboratory of Polymeric Materials&Application Technology of Hunan Province Xiangtan UniversityXiangtan411105China

Interleukin 2 (IL-2) is widely used as an active immunotherapeutic agent in clinical metastatic cancers. However, its therapeutic concentrations do not last long due to its short half-life. Thus, only a transient proliferation of the anti-cancer CD8+ T cells can be achieved, resulting in poor efficacy. Therefore, the aim of this work was to create a system that promotes CD8+ T cell proliferation at the tumor site using IL-2 persistently present and activates an anti-cancer immune response. This goal was achieved by the design of the IL-2-loaded polypeptide nanoparticles (P-IL-2) where methoxy poly(ethylene glycol) block poly-[(N-2-hydroxyethyl)-aspartamide] phenylboronic acid was used to encapsulate IL-2 through boron-nitrogen coordination with poly(L-lysine). P-IL-2 significantly prolonged the circulation time of IL-2 and achieved a selective drug release at the tumor site in the presence of high levels of reactive oxygen species, thus activating an anti-cancer immune response and exerting a better anti-cancer effect. The half-life of P-IL-2 was 3.15-fold higher than that of IL-2, and the quantity of CD8+ T cells after using P-IL-2 was 1.89-fold higher than that after using IL-2. In addition, the combination of P-IL-2 and anti-CTLA-4 monoclonal antibody resulted in an enhanced immune activation. Hence, this work provides a new approach to improve the efficacy of IL-2 in anti-cancer immunotherapy.

关键词： Polypeptide Phenylboronic acid boron-nitrogen coordination Interleukin 2 ROS-responsive

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