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Surgical and immune reconstitution murine models in bone marrow research: Potential for exploring mechanisms in sepsis, trauma and allergy

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World Journal of Experimental Medicine 2017年第3期7卷 58-77页

作者： Pedro Xavier-Elsas Renato Nunes Ferreira Maria Ignez C Gaspar-Elsas Department of Immunology Instituto de Microbiologia Paulo de GóesUniver-sidade Federal do Rio de Janeiro Department of Pediatrics Instituto Nacional de Saúde da Mulherda Crian?a e do Adolescente Fer-nandes FigueiraFIOCRUZ

bone marrow, the vital organ which maintains lifelong hemopoiesis, currently receives considerable attention, as a source of multiple cell types which may play important roles in repair at distant sites. This emerging function, distinct from, but closely related to, bone marrow roles in innate immunity and inflammation, has been characterized through a number of strategies. However, the use of surgical models in this endeavour has hitherto been limited. Surgical strategies allow the experimenter to predetermine the site, timing, severity and invasiveness of injury; to add or remove aggravating factors(such as infection and defects in immunity) in controlled ways; and to manipulate the context of repair, including reconstitution with selected immune cell subpopulations. This endows surgical models overall with great potential for exploring bone marrow responses to injury, inflammation and infection, and its roles in repair and regeneration. We review three different murine surgical models, which variously combine trauma with infection, antigenic stimulation, or immune reconstitution, thereby illuminating different aspects of the bone marrow response to systemic injury in sepsis, trauma and allergy. They are:(1) cecal ligation and puncture, a versatile model of polymicrobial sepsis;(2) egg white implant, an intriguing model of eosinophilia induced by a combination of trauma and sensitization to insoluble allergen; and(3) ectopic lung tissue transplantation, which allows us to dissect afferent and efferent mechanisms leading to accumulation of hemopoietic cells in the lungs. These models highlight the gain in analytical power provided by the association of surgical and immunological strategies.

关键词： bone-marrow Trauma Repair Transplantation Surgery

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Advance in hematopoietic stem cells transplantation for leukemia

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Chinese Medical Journal 2008年第18期121卷 1763-1765页

作者： HUANG Xiao-jun Institute of Hematology People's Hospital Peking University Beijing 100044 China

uring the past 50 years, intensive studies into the characteristics of hematopoietic stem cell transplantation immunology immunosuppressant and and the emergence of new anti-infective drugs have significantly improved... 详细信息

关键词： marrow-TRANSPLANTATION bone-marrow HIGH-RISK INFUSION RELAPSE BLOOD OUTCOMES CHILDREN DISEASE

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