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Multi-modal investigation of the bone micro- and ultrastructure, and elemental distribution in the presence of Mg-xGd screws at mid-term healing stages

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Bioactive Materials 2024年第11期41卷 657-671页

作者： Kamila Iskhakova Hanna Cwieka Svenja Meers Heike Helmholz Anton Davydok Malte Storm Ivo Matteo Baltruschat Silvia Galli Daniel Pröfrock Olga Will Mirko Gerle Timo Damm Sandra Sefa Weilue He Keith MacRenaris Malte Soujon Felix Beckmann Julian Moosmann Thomas O'Hallaran Roger J.Guillory II D.C.Florian Wieland Berit Zeller-Plumhoff Regine Willumeit-Römer florian wieland berit zeller-plumhoffregine willumeit-römer1institute of metallic biomaterialshelmholtz zentrum hereongeesthachtgermany institute of materials physiscs helmholtz zentrum hereongeesthachtgermany deutsches elektronen-synchrotron desy hamburggermany department of prosthodontics faculty of odontologyuniversity of malmömalmösweden institute of coastal environmental chemistry helmholtz zentrum hereongeesthachtgermany molecular imaging north competence center kiel universitykielgermany the department of oral and maxillofacial surgery campus kiel ukshkielgermany department of biomedical engineering michigan technological universityusa department of microbiology and biochemistry michigan state universityusa joint department of biomedical engineering medical college of wisconsinusa institute of materials mechanics helmholtz zentrum hereongeesthachtgermany

Magnesium(Mg)–based alloys are becoming attractive materials for medical applications as temporary bone implants for support of fracture healing,*** a suture *** to their mechanical properties and biocompatibility,they may replace titanium or stainless-steel implants,commonly used in orthopedic ***,patient safety has to be assured by finding a long-term balance between metal degradation,osseointegration,bone ultrastructure adaptation and element distribution in *** order to determine the implant behavior and its influence on bone and tissues,we investigated two Mg alloys with gadolinium contents of 5 and 10 wt percent in comparison to permanent materials titanium and polyether ether *** implants were present in rat tibia for 10,20 and 32 weeks before sacrifice of the *** radiation-based micro computed tomography enables the distinction of features like residual metal,degradation layer and bone ***,X-ray diffraction and X-ray fluorescence yield information on parameters describing the bone ultrastructure and elemental composition at the bone-to-implant ***,with element specific mass spectrometry,the elements and their accumulation in the main organs and tissues are *** results show that Mg-xGd implants degrade in vivo under the formation of a stable degradation layer with bone remodeling similar to that of Ti after 10 *** accumulation of Mg and Gd was observed in selected organs,except for the interfacial bone after 8 months of ***,we confirm that Mg-5Gd and Mg-10Gd are suitable material choices for bone implants.

关键词： Biodegradable implants bone ultrastructure Degradation Mg-based alloys

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Nanomechanics and ultrastructure of bone:A Review

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Computer Modeling in Engineering & Sciences 2020年第10期125卷 1-32页

作者： Mohammad Maghsoudi-Ganjeh Xiaodu Wang Xiaowei Zeng Department of Mechanical Engineering The University of Texas at San AntonioOne UTSA CircleSan AntonioTX 78249USA

In this review,a brief presentation is first given to the hierarchical structure and mechanical behavior of ***,the recent advancements in nanoscale characterization of bone ultrastructure and ingredients are discussed based on an extensive quantity of references in the ***,computational and analytical bone mechanics at ultrastructure levels are critically reviewed with the growing body of knowledge in the *** computational and analytical models are summarized in several categories for ease of understanding bone nanomechanics and their applicability/*** review is expected to provide a well-informed foundation for the researchers interested in interrogating the complex biomechanical response of bone at its nanoscale hierarchy.

关键词： bone ultrastructure nanoscale mechanical properties simulation and modeling strength toughness

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Bioinspired design of hybrid composite materials

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International Journal of Smart and Nano Materials 2019年第1期10卷 90-105,I0004页

作者： Mohammad Maghsoudi-Ganjeh Liqiang Lin Xiaodu Wang Xiaowei Zeng Department of Mechanical Engineering University of Texas at San AntonioSan AntonioTXUSA

Mimicking the natural design motifs of structural biological materials is a promising approach to achieve a unique combination of strength and toughness for engineering *** this study,we proposed a 2D computational model,which is a two-hierarchy hybrid composite inspired by the ultrastructural features of *** model is composed of alternating parallel array of two subunits(A&B)mimicking‘mineralized collagen fibril’and‘extrafibrillar matrix’of bone at ultrastructural *** subunit-A is formed by short stiff platelets embedded within a soft *** subunit-B consists of randomly distributed stiff grains bonded by a thin layer of tough adhesive *** assess the performance of the bioinspired design,a conventional unidirectional long-fiber composite made with the same amount of hard and soft phases was *** finite element simulation results indicated that the toughness,strength and elastic modulus of the bioinspired composite was 312%,83%,and 55%of that of the conventional composite,*** toughness improvement was attributed to the prevalent energy-dissipating damage of adhesive phase in subunit-B and crack-bridging by subunit-A,the two major toughening mechanisms in the *** study exemplifies some insights into natural design of materials to gain better material performance.

关键词： Bioinspired composites material design bone ultrastructure cohesive finite element material damage

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