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Clinical correlations between chronic hepatitis C infection and decreasing bone mass density after treatment with interferon-alpha

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Asian Pacific Journal of Tropical Biomedicine 2017年第2期7卷 161-165页

作者： Vahid Babaei Masoud Ghorbani Nastaran Mohseni Hojjat Afraid Yassaman Saghaei Shahram Teimourian Department of Medical Genetics Iran University of Medical SciencesTehranIran Department of Research and Development Research and Production ComplexPasteur Institute of IranKarajIran Biotechnology Research Center Biotechnology DepartmentVenom&Biotherapeutics Molecules LaboratoryPasteur Institute of IranTehranIran Iranian Blood Transfusion Organization TehranIran

Objective: To compare the bone mass density in chronic hepatitis patients before and after interferon-a ***: A total of 70 patients with chronic hepatitis C were treated with interferon-a and were evaluated. The treatment dosage was three million IU three times a week for one year. All the patients underwent bone mass density detection at lumbar spine and femoral neck before and after the interferon-a treatment. All the necessary information such as age,sex, and laboratory test, history of occurrence of fractures, lifestyle, and menopause status was collected by interviewers face-to-face from participants at the research visit. Smoking was categorized by whether participants were nonsmokers or smokers. Menopause was designated if there had been complete cessation of menses for more than 12 months. All statistical analyses were performed by SPSS version 14(SPSS, Inc., Chicago, IL, USA).Results: Among 70 patients, 52% were male, 48% were female and the mean age was(57.0 ± 9.6) years(range: 24–79). Twenty-nine percent of the patients had a history of smoking. The mean body mass index was(24.4 ± 3.6) kg/m^2(range: 18.4–35.3). Of the70 cases, 21 had high fibrosis-4. The prevalence of overall fracture history was 2.9%(two patients).Conclusions: Chronic hepatitis C virus infection did increase the risk of development of metabolic bone disease in this cohort. Indeed, greater reduction of bone mass density occurs in advanced liver fibrosis. The bone loss in earlier stages of chronic hepatitis C infection is likely to result from increased bone reduction rather than decreased bone formation. Overall, these observations suggest an important role for chronic hepatitis C virus infection in increased bone turnover in osteodystrophy pathogenesis.

关键词： Hepatitis C Interferon alpha bone mass density Liver fibrosis bone mass loss

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Salmon calcitonin in prevention of osteoporosis in maintenance dialysis patients

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Chinese Medical Journal 2008年第14期121卷 1280-1284页

作者： WANG Shi-xiang LI Han Blood Purification Center Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

Background Renal osteodystrophy is one of the commonest complications of chronic renal failure. It may have a severe impact on the quality of life of patients on maintenance dialysis therapy. Besides post-menopausal women and elderly people, the dialysis patients are another high risk group. But at present, there is no research on how to prevent osteoporosis in maintenance dialysis patients. This study was conducted to observe the bone density of maintenance dialysis patients and to evaluate the clinical outcomes and safety of different administration dosage of salmon calcitonin to prevent osteoporosis in maintenance dialysis patients. Methods One hundred and forty-eight patients on maintenance dialysis were involved in the 12-month, randomized, controlled trial. Fifty patients （experiment I group） received subcutaneous injection of salmon calcitonin （50 U） three times a week for 12 months. Fifty patients （experiment II group） received subcutaneous injection of salmon calcitonin （100 U） three times a week for 12 months. At the same time, both of them received oral calcium carbonate 1500 mg tid and rocaltrol 0.25 pg qn for 12 months. The control group only received oral calcium carbonate 1500 mg tid and rocaltrol 0.25 μg qn for 12 months. The levels of bone mass density （BMD） of the lumbar spine and femoral neck, serum intact parathyroid hormone （iPTH）, osteocalcin （OC）, calcium, phosphorus, alkaline phosphatase （ALP） were assessed at baseline and then again after 3, 6 and 12 months of treatment. Results The values of BMD at the lumbar spine and femoral neck before the treatment were not significantly different from those 3, 6, and 12 months after the treatment in trial groups I and II （all P 〉0.05） and there were no significant differences in the BMD values at different time points between trial groups I and II. In the control group, the BMD values at the lumbar spine and femoral neck 3, 6, and 12 months after the beginning of trial were significantly lower than

关键词： dialysis oestoporosis bone mass density salmon calcitonin

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The Effect of the Phytoestrogen Genistein on Metabolism of bones in Ovariectomy Rats

The Effect of the Phytoestrogen Genistein on Metabolism of B...

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现代化中药制剂发展与中药药理学研究交流会

作者： JiYuan.Sun~a,JiPeng.Li~b,Shan.Miao~a,Hongying Wang~d,SiWang.Wang~a,qiang jie~c,Yan.Hua.Xie~a, Jian.Bo Wang~a,Qian Yang~a a Institute of Material Medical,School of Pharmacy,b Department of Gastrointestinal Surgery,c Department of Orthopaedics Surgery,Xijing Hospital d Department of Obstetrics and Gynecology,Xijing Hospital Fourth Military Medical University,Xi’an 710033,China.

目的观察染料木素对实验性去卵巢大鼠诱发的骨质疏松症模型的治疗作用。方法:60只SD雌性大鼠行去卵巢术后,随机分为正常对照组、模型组、骨疏康组、尼尔雌醇组、染料木素大、中和小剂量组,每组10只。各组动物给予盐酸四环素25 mg·kg连... 详细信息

目的观察染料木素对实验性去卵巢大鼠诱发的骨质疏松症模型的治疗作用。方法:60只SD雌性大鼠行去卵巢术后,随机分为正常对照组、模型组、骨疏康组、尼尔雌醇组、染料木素大、中和小剂量组,每组10只。各组动物给予盐酸四环素25 mg·kg连续3d,同时给予治疗用药,剂量为Gsk 5 g·kg,Nilestriol为1.5 mg·kg,染料木素分别为18、9、4.5 mg·kg,以上给药除尼尔雌醇每周1次外其它各组均为每日1次。给药后12 wk后进行相关指标的测定。结果:①染料木素4.5mg·kg、9 mg·kg连续给药12 wk可抑制体重增加,使其股骨干重、灰重、骨钙及股骨和腰椎骨密度显著增加,与模型组比较具有显著差异(P<0.05或P<0.01);②染料木素4.5mg·kg、9 mg·kg连续给药12wk可显著改善模型大鼠的股骨及椎骨最大载荷、最大桡度、弹性载荷、弹性桡度(P<0.05或p<0.01);③染料木素低中剂量给药12wk后,可使模型大鼠的血清Ca,Mg,P,CT水平增加,BGP、ALP水平下降(P<0.05或P<0.01)。结论:染料木素对模型动物的骨密度、骨生物力学及相关生化指标都具有改善作用,具有较好的抗骨质疏松作用。

关键词： Genistein ovariectomized bone mass density Serum biochemical criterion Biomechanics Osteoporosis

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杭州男性骨密度和骨质疏松影响因素的研究

杭州男性骨密度和骨质疏松影响因素的研究

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第四届国际骨质疏松研讨会暨第二届国际骨矿研究会议

作者：倪旻丁国民陈作人杭州第一人民医院

＜正＞目的评价杭州市男性健康人群的骨量和骨质疏松（OP）的发病情况。方法568名健康男性采用Sunlight的超声骨密度测定仪检测胫骨的超声速度值（SOS）。并按年龄、民族、生活习惯进行分组,以10岁为一个年龄组,生活习惯包括吸烟、酗酒... 详细信息

＜正＞目的评价杭州市男性健康人群的骨量和骨质疏松（OP）的发病情况。方法568名健康男性采用Sunlight的超声骨密度测定仪检测胫骨的超声速度值（SOS）。并按年龄、民族、生活习惯进行分组,以10岁为一个年龄组,生活习惯包括吸烟、酗酒、少户外活动（少于1小时/天）和喝咖啡。结果杭州男性骨SOS峰值年龄在30-39岁,60岁以后OP患病率23.9%,过量吸烟、饮酒和喝咖啡者骨SOS值低于同年龄组,户外活动者（如爬山、慢跑）平均

关键词： Healthy man bone mass density Osteoporosis

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