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Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis

Chinese Medical Journal 2021年第21期134卷 2583-2588页

作者： Yukchiu Chung Zhi-Chang Li Xiao-Lin Sun Yan-Ying Liu Miao Shao Yu-Zhou Gan Yi-Min Li Yu-Hui Li Xue-Wu Zhang Department of Rheumatology and Immunology Beijing Key Laboratory for Rheumatism and Immune Diagnosis(BZ0135)Peking University People’s HospitalBeijing 100044China Arthritis Clinic and Research Center Peking University People’s HospitalBeijing 100044China

Background:Psoriatic arthritis(PsA)is an inflammatory arthropathy characterized by psoriasis and bone erosion on ***-1(Dkk-1)is considered to be the main inhibitor of the Wnt signaling pathway and results in reduced osteoblast *** aim of this study was to investigate the serum level of Dkk-1 and its association with bone erosion in PsA ***:Serum Dkk-1 levels were measured by enzyme-linked immunosorbent assay(ELISA)in 69 patients with PsA and 60 controls,including 39 rheumatoid arthritis(RA)patients,and 21 healthy controls(HCs).Rheumatoid factor and anti-cyclic citrullinated peptide levels were also determined by *** association of Dkk-1 level with clinical and laboratory features of PsA was *** regression analysis was used to analyze the risk factors for bone erosion in ***:Dkk-1 was elevated in 68.1%(47/69)of the patients with PsA,46.2%(18/39)of RA patients,and 9.5%(2/21)of *** Dkk-1 concentration was significantly higher in PsA patients compared with that in *** level of serum Dkk-1 was correlated with a swollen joint count,and levels of complement components 3 and *** Dkk-1 level(odds ratio=4.440,95%confidence interval:1.246-15.817,P=0.021)was identified as the risk factor for bone erosion in ***:The serum level of Dkk-1 is abnormally elevated in PsA *** elevation of Dkk-1 might be involved in the mechanism of bone erosion in patients with PsA.

关键词： Dickkopf-1 Psoriatic arthritis bone erosion

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Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis

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Chinese Journal of Natural Medicines 2022年第6期20卷 458-472页

作者： ZHANG Yan TANG Li-Dong WANG Jian-Ying WANG Hao CHEN Xiao-Yun ZHANG Lei YUAN Ying School of Traditional Chinese Materia Medica Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Innovation Center of TCM Health Service Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Key Laboratory of Formulated Chinese Medicines Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Longhua Hospital affiliated to Shanghai University of TCM Rheumatoid DepartmentShanghai 200232China

Rheumatoid arthritis(RA)is a chronic inflammatory autoimmune *** is known that aucubin(AU)exerts anti-inflammatory activity,but its effects and mechanisms in RA are *** study investigated the anti-inflammatory effects and mechanisms of AU in vivo and in *** fibroblast-like synoviocyte cells from patients with RA(HFLS-RA),RAW264.7 cells,and MC3T3-E1 cells were used to evaluate the effects of AU on migration,invasion,apoptosis,osteoclast differentiation and *** was used to observe nuclear translocation of nuclear factor(NF)-/cB,the double luciferase reporter gene method was used to observe NF-/cB-p65 activity in AU-treated MC3T3-E1 ***-qPCR was used to measure expression of bone metabolism and inflammation-related genes,and western blot was used to measure bone metabolism and NF-a:B protein expression ***-induced arthritis(CIA)rat model was used for pharmacodynamics *** indexes were measured in the ankle and knee,histological staining and Micro-computed tomography were performed on the ankle ***,inflammatory factor gene expression and the levels of NF-/cB-related proteins were detected as in *** effectively inhibited HFLS-RA cell migration and invasion,promoted apoptosis,and inhibited RAW264.7 cell differentiation into osteoclasts,as well as inhibited NF-/cB-p65 activity in MC3T3-E1 ***,AU significantly reduced the gene expression levels of three cell-related inflammatory factors and bone metabolism factors,effectively inhibited the expression of p-lKKafi,p-lA:Ba,and p-p65 *** vivo,AU relieved joint inflammation,reduced related inflammatory factors,and inhibited NF-/cB *** could be used to treat RA-related synovial inflammation and bone destruction through the NF-/cB pathway.

关键词： Aucubin Collagen-induced arthritis Synovial inflammation bone erosion NF-/cB signaling pathway

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