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Construction of Customized Bio Incubator and Designing of Tailored Scaffolds for bone Tissue engineering from Laboratory Scale Up to Clinical Scale

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Journal of Renewable Materials 2022年第11期10卷 2699-2716页

作者： Soliman Abdalla Shiref Kandil Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Materials Science Institute of Graduate Studies and ResearchAlexandria UniversityAlexandriaEgypt

In order to obtain larger,clinical-scale and practical-scale bone grafts,we have designed both tailored scaffolds and tailored bio incubator with optimal bio-production characteristics.Using DIC files to Simpleware Scan-IP(Simple-ware-exeter United Kingdom),we have digitally reconstructed segmental additive bone-tissue in order to perform images processing.Both hydroxyapatite and tannin composites have been used in order to get the final bone modules combined for retexturing of segmental bone defect.We have found that sectioning of bone segment deficiency reorganizations into well disk-shaped design permits one to standardize the cell culture and seeding protocol,to get better products.The present study concludes that some techniques with cultured cell in segmental bone grafts in the laboratory can be transferred and clinically used.

关键词： Repairing segmental bone customized scaffolds stem cells designing bio incubator bone engineering

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Adipose tissue in bone regeneration-stem cell source and beyond

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World Journal of Stem Cells 2022年第6期14卷 372-392页

作者： Luminita Labusca Magnetic Materials and Sensors National Institute of Research and Development for Technical PhysicsIasi 700050Romania Orthopedics and Traumatology County Emergency Hospital Saint Spiridon IasiIasi 700050Romania

Adipose tissue(AT)is recognized as a complex organ involved in major homeostatic body functions,such as food intake,energy balance,immunomodulation,development and growth,and functioning of the reproductive organs.The role of AT in tissue and organ homeostasis,repair and regeneration is increasingly recognized.Different AT compartments(white AT,brown AT and bone marrow AT)and their interrelation with bone metabolism will be presented.AT-derived stem cell populations-adipose-derived mesenchymal stem cells and pluripotentlike stem cells.Multilineage differentiating stress-enduring and dedifferentiated fat cells can be obtained in relatively high quantities compared to other sources.Their role in different strategies of bone and fracture healing tissue engineering and cell therapy will be described.The current use of AT-or AT-derived stem cell populations for fracture healing and bone regenerative strategies will be presented,as well as major challenges in furthering bone regenerative strategies to clinical settings.

关键词： Adipose tissue bone metabolism Fracture healing Adipose-derived stem cells Multilineage differentiating stress-enduring Dedifferentiated fat cells bone engineering

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The Effect of Bionic Scaffolds with graded pore size on bone engineering

The Effect of Bionic Scaffolds with graded pore size on Bone...

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中华口腔医学会第14次全国口腔医学学术会议（2012年...

作者： Jingwen YANG,DDS,MD Department of Prosthodontics,Peking University School of Stomatology

Objective:To investigate the effect of bionicβ-tricalcium phosphate(β-TCP) scaffolds with graded pore size on bone tissue augmentation. Methods:β-TCP scaffolds mimicking natural mandibular structure were designed,

关键词： bone engineering graded pore size β-tricalciμm phosphate scaffolds

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